Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

2004 • 11,185 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Distinct Sets of Genetic Alterations in Melanoma

2005 • 2,597 citations

BRAFE600-associated senescence-like cell cycle arrest of human naevi

2005 • 2,054 citations

High frequency of BRAF mutations in nevi

2002 • 1,701 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma

2005 • 653 citations

Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis

2006 • 636 citations

Deregulated Akt3 Activity Promotes Development of Malignant Melanoma

2004 • 566 citations

A negative feedback signaling network underlies oncogene-induced senescence

2006 • 480 citations

PTEN signaling pathways in melanoma

2003 • 472 citations

Genetic Interaction Between NRAS and BRAF Mutations and PTEN/MMAC1 Inactivation in Melanoma

2004 • 470 citations

Suppression of BRAF(V599E) in human melanoma abrogates transformation.

2003 • 412 citations

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

1997 • 405 citations

Examination of Mutations in BRAF, NRAS, and PTEN in Primary Cutaneous Melanoma

2005 • 382 citations

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

2006 • 380 citations

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

2006 • 375 citations

Mutant V599EB-Raf Regulates Growth and Vascular Development of Malignant Melanoma Tumors

2005 • 316 citations

Prognostic Significance of Activated Akt Expression in Melanoma: A Clinicopathologic Study of 292 Cases

2005 • 309 citations

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61K on an INK4a-Deficient Background

2005 • 284 citations

Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.

2002 • 256 citations

Genetic Alterations in Signaling Pathways in Melanoma

2006 • 197 citations

p16Ink4a in Melanocyte Senescence and Differentiation

2002 • 174 citations

Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas

2001 • 165 citations

A genome-based strategy uncovers frequent BRAF mutations in melanoma

2002 • 152 citations

Amplification of CDK4 and MDM2 in malignant melanoma

2006 • 141 citations

New evidence for presence of tyrosinase in substantia nigra, forebrain and midbrain

1998 • 103 citations

Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma

1993 • 99 citations

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo

2003 • 99 citations

Normal murine melanocytes in culture

1987 • 82 citations

Lack of Association between BRAF Mutation and MAPK ERK Activation in Melanocytic Nevi

2005 • 73 citations

Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma

2005 • 62 citations

Tyrosinase‐Cre mice for tissue‐specific gene ablation in neural crest and neuroepithelial‐derived tissues

2003 • 47 citations

ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2

2007 • 15 citations