On immunoglobulin heavy chain gene switching: two γ2b genes are rearranged via switch sequences in MPC-11 cells but only one is expressed

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

The use of thin acrylamide gels for DNA sequencing

1978 • 1,449 citations

Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning

1977 • 951 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells

1978 • 324 citations

An immunoglobulin heavy-chain gene is formed by at least two recombinational events

1980 • 306 citations

Structure of chi hotspots of generalized recombination

1981 • 297 citations

SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS

1970 • 284 citations

The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genes

1981 • 260 citations

DNA Sequences Mediating Class Switching in α-Immunoglobulins

1980 • 243 citations

5′ Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains

1980 • 238 citations

Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes

1981 • 219 citations

Rate of Somatic Mutation in Immunoglobulin Production by Mouse Myeloma Cells

1971 • 213 citations

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

1980 • 213 citations

Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D

1980 • 188 citations

Switch region of immunoglobulin Cμ gene is composed of simple tandem repetitive sequences

1981 • 173 citations

A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events

1980 • 158 citations

SPECIAL SITES IN GENERALIZED RECOMBINATION

1979 • 147 citations

Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms

1981 • 143 citations

Cloning of human immunoglobulin μ gene and comparison with mouse μ gene

1980 • 124 citations

An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing

1980 • 121 citations

Sequence of the Cloned Gene for the Constant Region of Murine γ2b Immunoglobulin Heavy Chain

1979 • 117 citations

Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.

1981 • 99 citations

Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes.

1980 • 97 citations

RNA splicing generates a variant light chain from an aberrantly rearranged κ gene

1980 • 95 citations

Complete nucleotide sequence of immunoglobulin γ2b chain gene cloned from newborn mouse DNA

1980 • 93 citations

Chi, a promoter of generalized recombination in λ phage, is present in immunoglobulin genes

1981 • 90 citations

Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype.

1975 • 84 citations

Variants of Mouse Myeloma Cells That Produce Short Immunoglobulin Heavy Chains

1974 • 76 citations

Structure of the Constant and 3′ Untranslated Regions of the Murine γ2b Heavy Chain Messenger RNA

1979 • 66 citations

Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants

1975 • 57 citations

Nucleotide sequences of class-switch recombination region of the mouse immunoglobulin λ2b-chain gene

1980 • 54 citations

IgG2a-producing variants of an IgG2b-producing mouse myeloma cell line.

1978 • 48 citations

An IgG_2a-producing variant of an IgG_2b-producing mouse myeloma cell line. Structural studies on the Fc region of parent and variant heavy chains

1978 • 42 citations

Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family.

1981 • 41 citations

An unusual translocation of immunoglobulin gene segments in variants of the mouse myeloma MPC11

1980 • 40 citations

The 5′-terminal sequences of immunoglobulin messenger RNAs of a mouse myeloma

1978 • 28 citations

Cloning and sequence of the cDNA corresponding to the variable region of immunoglobulin heavy chain MPC11

1980 • 28 citations

Genetic Mechanism Accounting for Precise Immunoglobulin Domain Deletion in a Variant of MPC 11 Myeloma Cells

1979 • 23 citations

Generation of Antibody Diversity

2018 • 19 citations

Recombination events near the immunoglobulin C.mu. gene join variable and constant region genes, switch heavy-chain expression, or inactivate the locus

1981 • 16 citations

Cloned embryonic DNA sequences flanking the mouse immunoglobulin C_γ3and C_γ1genes

1980 • 15 citations

Studies on the Nature and Germ-line Stability of DNA Sequences Flanking the Mouse Immunoglobulin Heavy-chain Constant-region Genes

1981 • 14 citations

Organization of the sequences flanking immunoglobulin heavy chain genes and their role in class switching

1980 • 8 citations