Engineering hematopoietic grafts: Purified allogeneic hematopoietic stem cells plus expanded CD8+ NK-T cells in the treatment of lymphoma

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

1990 • 1,544 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

CD1 Recognition by Mouse NK1 ⁺ T Lymphocytes

1995 • 903 citations

Role of NK1.1 ⁺ T Cells in a T _H 2 Response and in Immunoglobulin E Production

1995 • 508 citations

Mouse CD94/NKG2A Is a Natural Killer Cell Receptor for the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule Qa-1b

1998 • 491 citations

Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived lymphocytes, and natural killer cells

1983 • 477 citations

A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency.

1994 • 438 citations

Pathophysiologic mechanisms of acute graft-vs.-host disease

1999 • 348 citations

Phenotypic characterization and identification of effector cells involved in tumor cell recognition of cytokine-induced killer cells.

1993 • 321 citations

Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation.

1998 • 305 citations

Spontaneous murine B-cell leukaemia

1978 • 264 citations

Annexin V used for measuring apoptosis in the early events of cellular cytotoxicity

1999 • 240 citations

Recognition of the Class Ib Molecule Qa-1b by Putative Activating Receptors Cd94/Nkg2c and Cd94/Nkg2e on Mouse Natural Killer Cells

1999 • 233 citations

Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon γ production

2001 • 232 citations

Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.

1997 • 229 citations

Graft-versus-leukemia: no longer an epiphenomenon [editorial]

1993 • 197 citations

Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta.

1999 • 195 citations

Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

1998 • 188 citations

Transplantation of highly purified CD34+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer

2000 • 166 citations

Graft-Versus-Leukemia Effect and Graft-Versus-Host Disease Can Be Differentiated by Cytotoxic Mechanisms in a Murine Model of Allogeneic Bone Marrow Transplantation

1999 • 144 citations

Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors

2000 • 133 citations

The Graft-Versus-Leukemia Effects of Allogeneic Cell Therapy

1999 • 130 citations

Transplantation of purified hematopoietic stem cells: requirements for overcoming the barriers of allogeneic engraftment.

1996 • 124 citations

Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma

2000 • 111 citations

Collection, Tumor Contamination, and Engraftment Kinetics of Highly Purified Hematopoietic Progenitor Cells to Support High Dose Therapy in Multiple Myeloma

1998 • 109 citations

Expansion of Philadelphia Chromosome–Negative CD3+CD56+ Cytotoxic Cells From Chronic Myeloid Leukemia Patients: In Vitro and In Vivo Efficacy in Severe Combined Immunodeficiency Disease Mice

1998 • 109 citations

Graft Versus Leukemia1 1Supported by American Cancer Society Grant ET-55 and a grant from the Board of Trustees, Mount Sinai Medical Center, Milwaukee, Wisconsin.

1974 • 102 citations

Molecular Mechanisms of Immune-Mediated Lysis of Murine Renal Cancer: Differential Contributions of Perforin-Dependent Versus Fas-Mediated Pathways in Lysis by NK and T Cells

1998 • 83 citations

Tumor Regression After Adoptive Transfer of Effector T Cells Is Independent of Perforin or Fas Ligand (APO-1L/CD95L)

1999 • 82 citations

Cure of Hematologic Neoplasia with Transplantation of Marrow from Identical Twins

1977 • 74 citations

From stem cells to lymphocytes; biology and transplantation

1997 • 72 citations

Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin.

1982 • 69 citations

Immunobiology of a Spontaneous Murine B Cell Leukemia (BCL₁)

1979 • 65 citations

Graft-vs.-host and graft-vs.-leukemia reactions after delayed infusions of donor T-subsets

1999 • 64 citations

Characterization of a spontaneous murine B cell leukemia (BCL1). I. Cell surface expression of IgM, IgD, Ia, and FcR.

1979 • 64 citations

THE ROLE OF PURIFIED CD8+ T CELLS IN GRAFT-VERSUS-LEUKEMIA ACTIVITY AND ENGRAFTMENT AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION

1995 • 63 citations

IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease.

1994 • 51 citations

Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase

1994 • 40 citations

Graft-vs.-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model

1999 • 39 citations

The graft-versus-leukemla effect

1996 • 13 citations

The roles of Fas and perforin in LAK T-cell/bispecific antibody-mediated killing of the murine B-lymphoma cells, BCL1

1996 • 4 citations

Cited By (0)

Loading...