Crystal structure of wild‐type human procathepsin K

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

1996 • 1,003 citations

EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY

1997 • 767 citations

Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors.

1997 • 446 citations

Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

1996 • 427 citations

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

1996 • 379 citations

Two distinct gene subfamilies within the family of cysteine protease genes.

1993 • 354 citations

Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry

1997 • 194 citations

Potency and Selectivity of the Cathepsin L Propeptide as an Inhibitor of Cysteine Proteases

1996 • 193 citations

Potent slow-binding inhibition of cathepsin B by its propeptide

1992 • 173 citations

Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

1996 • 170 citations

Autocatalytic Activation of Human Cathepsin K

1997 • 155 citations

Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain‐like cysteine protease and its propeptide

1996 • 139 citations

Cathepsin Z, a Novel Human Cysteine Proteinase with a Short Propeptide Domain and a Unique Chromosomal Location

1998 • 131 citations

Design of potent and selective human cathepsin K inhibitors that span the active site

1997 • 119 citations

Human cathepsin W, a putative cysteine protease predominantly expressed in CD8⁺ T‐lymphocytes

1997 • 111 citations

Recombinant pro-regions from papain and papaya proteinase IV are selective high affinity inhibitors of the mature papaya enzymes

1995 • 111 citations

Crystal structure of the wild-type human procathepsin B at 2.5 Å resolution reveals the native active site of a papain-like cysteine protease zymogen

1997 • 109 citations

The prosequence of procaricain forms an α-helical domain that prevents access to the substrate-binding cleft

1996 • 107 citations

Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity

1997 • 93 citations

The Inhibition of Cathepsin S by its Propeptide — Specificity and Mechanism of Action

1997 • 75 citations

Structural basis for specificity of papain-like cysteine protease proregions toward their cognate enzymes

1998 • 74 citations

Engineering of proteases and protease inhibition

1991 • 10 citations