Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity

Ellman's reagent: 5,5′-dithiobis(2-nitrobenzoic acid)—a reexamination

1979 • 997 citations

[6] Efficient site-directed mutagenesis using uracil-containing DNA

1991 • 644 citations

Phase I Trial of Recombinant Immunotoxin Anti-Tac(Fv)-PE38 (LMB-2) in Patients With Hematologic Malignancies

2000 • 424 citations

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.

1987 • 248 citations

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

1991 • 219 citations

Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages

1987 • 176 citations

Responses in Refractory Hairy Cell Leukemia to a Recombinant Immunotoxin

1999 • 169 citations

Discovery of three genes specifically expressed in human prostate by expressed sequence tag database analysis

1998 • 148 citations

Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma

1994 • 137 citations

IgG antibody response to polyethylene glycol-modified adenosine deaminase in patients with adenosine deaminase deficiency.

1992 • 113 citations

Targeted delivery and improved therapeutic potential of catalase by chemical modification: combination with superoxide dismutase derivatives.

1999 • 110 citations

Hepatotoxicity in cancer patients receiving erb-38, a recombinant immunotoxin that targets the erbB2 receptor.

1999 • 106 citations

Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment

1994 • 101 citations

Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys

1999 • 87 citations

Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity.

1980 • 85 citations

Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.

1994 • 82 citations

Targeted therapy of cancer with recombinant immunotoxins

1997 • 75 citations

The determination of polyethylene glycol in gamma globulin solutions

1975 • 68 citations

Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40).

1991 • 66 citations

Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency

1995 • 64 citations

TargetingPseudomonasexotoxin to hematologic malignancies

1995 • 57 citations

Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.

1994 • 56 citations

Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.

1994 • 50 citations

Reduction of the Nonspecific Animal Toxicity of Anti-Tac(Fv)-PE38 by Mutations in the Framework Regions of the Fv Which Lower the Isoelectric Point

1999 • 49 citations

Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.

1993 • 43 citations

Polyethylene glycol modification of the monoclonal antibody A7 enhances its tumor localization

1990 • 42 citations

Molecular design of hybrid tumour necrosis factor-alpha. II: The molecular size of polyethylene glycol-modified tumour necrosis factor-alpha affects its anti-tumour potency

1996 • 36 citations

Pseudomonas exotoxin A mutants. Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.

1994 • 35 citations

On the Distortion in Conformal Mapping When the Second Coefficient in the Mapping Function Has an Assigned Value

1920 • 27 citations