The role(s) of Gangliosides in neural differentiation and repair: A perspective

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

[10] Gangliosides: Structure, isolation, and analysis

1982 • 705 citations

Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor.

1986 • 702 citations

The Isolation and Properties of a Rabbit Liver Binding Protein Specific for Asialoglycoproteins

1974 • 614 citations

Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation.

1984 • 501 citations

Gangliosides as membrane receptors for tetanus toxin, cholera toxin and serotonin

1974 • 391 citations

Ganglioside Stimulation of Axonal Sprouting in Vitro

1981 • 386 citations

Über die Ganglioside, eine neue Gruppe von zuckerhaltigen Gehirnlipoiden

1942 • 301 citations

Gangliosides in the nervous system

1983 • 299 citations

Specificity of binding of a strain of uropathogenic Escherichia coli to Gal alpha 1—-4Gal-containing glycosphingolipids.

1985 • 296 citations

Deactivation of Cholera Toxin by Ganglioside

1971 • 285 citations

[14] Glycosphingolipids: structure, biological source, and properties

1989 • 280 citations

Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease

1976 • 278 citations

Developmental Changes in Ganglioside Composition and Synthesis in Embryonic Rat Brain

1988 • 275 citations

Specific gangliosides function as host cell receptors for Sendai virus.

1981 • 262 citations

Regulation of protein kinase C activity by gangliosides.

1987 • 248 citations

Ganglioside Designation

1980 • 239 citations

Gangliosides in neurological and neuromuscular function, development and repair

1982 • 230 citations

Activation of (Na⁺, K⁺)‐ATPase by Nanomolar Concentrations of GM₁ Ganglioside

1981 • 212 citations

Human influenza A virus hemagglutinin distinguishes sialyloligosaccharides in membrane-associated gangliosides as its receptor which mediates the adsorption and fusion processes of virus infection. Specificity for oligosaccharides and sialic acids and the sequence to which sialic acid is attached.

1986 • 204 citations

Muscle reinnervation—III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides

1983 • 186 citations

A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.

1988 • 183 citations

Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.

1988 • 172 citations

Calcium/Ganglioside‐Dependent Protein Kinase Activity in Rat Brain Membrane

1985 • 170 citations

Neuraminsäure, das Spaltprodukt eines neuen Gehirnlipoids

1941 • 169 citations

Effects of Brain Gangliosides on Functional Recovery in Experimental Regeneration and Reinnervation

1976 • 159 citations

Ganglioside‐Induced Neuritogenesis: Verification That Gangliosides Are the Active Agents, and Comparison of Molecular Species

1983 • 157 citations

Interaction between Clostridium botulinum neurotoxin and gangliosides

1980 • 156 citations

G _M1 Ganglioside Treatment Facilitates Behavioral Recovery from Bilateral Brain Damage

1984 • 148 citations

Effect of gangliosides on adenylate cyclase activity in rat cerebral cortical membranes.

1979 • 144 citations

Antibodies to cell surface ganglioside GD3 perturb inductive epithelial-mesenchymal interactions

1988 • 142 citations

The stimulating effect of ganglioside injections on the recovery of choline acetyltransferase and acetylcholinesterase activities in the hippocampus of the rat after septal lesions

1982 • 140 citations

Growth factors and gangliosides: A possible new perspective in neuronal growth control

1979 • 135 citations

Incorporation of exogenous glycosphingolipids in plasma membranes of cultured hamster cells and concurrent change of growth behavior

1973 • 133 citations

Polystyrene‐Adsorbed Gangliosides for Investigation of the Structure of the Tetanus‐Toxin Receptor

1980 • 132 citations

Ganglioside treatment improves recovery of alternation behavior after unilateral entorhinal cortex lesion

1983 • 129 citations

Sprouting from chicken embryo dorsal root ganglia induced by nerve growth factor is specifically inhibited by affinity-purified antiganglioside antibodies.

1982 • 127 citations

Gangliosides support neural retina cell adhesion.

1986 • 113 citations

Meganeurites and other aberrant processes of neurons in feline GM1-gangliosidosis: A golgi study

1978 • 113 citations

Ganglioside changes in the chicken optic lobes as biochemical indicators of brain development and maturation

1982 • 110 citations

Chronic GM1 ganglioside treatment reduces dopamine cell body degeneration in the substantia nigra after unilateral hemitransection in rat

1984 • 107 citations

Ganglioside GD3: structure, cellular distribution, and possible function

1985 • 105 citations

Free Sphingosine Formation from Endogenous Substrates by a Liver Plasma Membrane System with a Divalent Cation Dependence and a Neutral pH Optimum

1989 • 102 citations

Development of diabetic neuropathy in the C57BL/Ks (db/db) mouse and its treatment with gangliosides

1984 • 102 citations

Gangliosides minimize behavioral deficits and enhance structural repair after brain injury

1984 • 101 citations

Treatment with GM1 Ganglioside Restores Striatal Dopamine in the 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Treated Mouse

1988 • 98 citations

Animal glycolipids as attachment sites for microbes

1986 • 96 citations

Ganglioside-specific Binding Protein on Rat Brain Membranes

1989 • 94 citations

Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-stimulated protein kinase in brain.

1987 • 93 citations

Binding of Vibrio cholera Toxin and the Heat-labile Enterotoxin of Escherichia coli to GM1, Derivatives of GM1, and Nonlipid Oligosaccharide Polyvalent Ligands

1989 • 92 citations

Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: II. Modulatory effects of gangliosides

1988 • 88 citations

Gangliosides as Paramyxovirus Receptor. Structural Requirement of Sialo-Oligosaccharides in Receptors for Hemagglutinating Virus of Japan (Sendai Virus) and Newcastle Disease Virus

1985 • 88 citations

Gangliosides and Modulation of Neuronal Functions

1987 • 87 citations

GM1 ganglioside enhances regrowth of noradrenaline nerve terminals in rat cerebral cortex lesioned by the neurotoxin 6-hydroxydopamine

1984 • 83 citations

Effects of ganglioside treatments on lesion‐induced behavioral impairments and sprouting in the CNS

1984 • 81 citations

Gangliosides and Modulation of Neuronal Functions

1991 • 80 citations

Gangliosides stimulate neurite outgrowth and induce tubulin mRNA accumulation in neural cells

1983 • 79 citations

Purification of enterotoxins from Vibrio mimicus that appear to be identical to cholera toxin

1984 • 78 citations

Effect of GM1 ganglioside treatment on postlesion responses of cholinergic enzymes in rat hippocampus after various partial deafferentations

1984 • 75 citations

Ganglioside Modulation of Cyclic AMP‐Dependent Protein Kinase and Cyclic Nucleotide Phosphodiesterase In Vitro

1989 • 75 citations

Gangliosides inhibit phospholipid‐sensitive Ca²⁺‐dependent kinase phosphorylation of rat myelin basic proteins

1986 • 74 citations

Activation of rat cerebral cortical 3',5'-cyclic nucleotide phosphodiesterase activity by gangliosides.

1980 • 74 citations

Parenterally administered GM1 ganglioside prevents retrograde degeneration of cholinergic cells of the rat basal forebrain

1986 • 73 citations

Isolation and characterization of a cholera-related enterotoxin fromSalmonella typhimurium

1983 • 73 citations

Inhibition of the steroidogenic effects of cholera and heat-labile Escherichia coli enterotoxins by GM1 ganglioside: evidence for a similar receptor site for the two toxins

1975 • 71 citations

Interaction of Ganglioside G_Gtet1 and Its Derivatives with Choleragen

1974 • 70 citations

Immunological relationship of the B subunits of Campylobacter jejuni and Escherichia coli heat-labile enterotoxins

1985 • 65 citations

The functional recovery of damaged brain: The effect of GM1 monosialoganglioside

1984 • 64 citations

Ganglioside-modulated protein phosphorylation in myelin.

1987 • 64 citations

Ganglioside and rabbit erythrocyte membrane receptor for staphylococcal alpha-toxin

1976 • 62 citations

Double‐blind evaluation of monosialoganglioside (GM₁) therapy in stroke

1984 • 60 citations

Modified ganglioside as a possible modulator of transmembrane signaling mechanism through growth factor receptors: A preliminary note

1987 • 59 citations

Identification of α-Galactose (α-Fucose)-asialo-GM1 Glycolipid Expressed by Subsets of Rat Dorsal Root Ganglion Neurons

1989 • 58 citations

GM1 ganglioside potentiates the effect of nerve growth factor in preventing vinblastine-induced sympathectomy in newborn rats

1988 • 58 citations

GM1 gangliosides stimulate neuronal reorganization and reduce rotational asymmetry after hemitransections of the nigro-striatal pathway

1985 • 57 citations

The EGF Receptor Kinase Substrate p35 in the Floor Plate of the Embryonic Rat CNS

1989 • 57 citations

ATPase Activity Defects in Alloxan-Induced Diabetic Sciatic Nerve Recovered by Ganglioside Treatment

1988 • 54 citations

Ganglioside-modulated protein phosphorylation. Partial purification and characterization of a ganglioside-inhibited protein kinase in brain.

1988 • 54 citations

The effect of GM1 ganglioside on cholinergic and serotoninergic systems in the rat hippocampus following partial denervation is dependent on the degree of fiber degeneration

1986 • 53 citations

Receptor ganglioside content of three hosts for sendai virus: MDBK, HeLa, and MDCK Cells

1984 • 52 citations

A role for gangliosides in astroglial cell differentiation in vitro.

1988 • 52 citations

PRODUCTION OF CHOLERA-LIKE ENTEROTOXIN BY AEROMONAS HYDROPHILA

1984 • 51 citations

Effects of GM<sub>1</sub> Ganglioside in Cerebrovascular Diseases: A Double-Blind Trial in 40 Cases

1985 • 51 citations

Antibodies to gangliosides inhibit goldfish optic nerve regeneration in vivo

1984 • 47 citations

Human placenta gangliosides

1988 • 47 citations

Ganglioside-mediated enhancement of the cytoskeletal organization and activity in neuro-2a neuroblastoma cells

1984 • 46 citations

Bioactive gangliosides: analysis of functional structures of the tetrasialoganglioside GQ1b which promotes neurite outgrowth

1986 • 46 citations

Ganglioside therapy in diabetic neuropathy

1986 • 44 citations

Developmental Changes of C-Series Polysialogangliosides in Chick Brains Revealed by Mouse Monoclonal Antibodies M6704 and M7103 with Different Epitope Specificities1

1988 • 44 citations

GM1 ganglioside protects nucleus basalis from excitotoxin damage: Reduced cortical cholinergic losses and animal mortality

1988 • 42 citations

Ganglioside Composition of Normal and Mutant Mouse Embryos

1989 • 41 citations

Monosialoganglioside internal ester stimulates the dopaminergic reinnervation of the striatum after unilateral hemitransection in rat

1984 • 40 citations

Cell cycle phases of a novel human neural cell line and the effect of exogenous gangliosides

1982 • 39 citations

Ganglioside G_M1 Antibodies and B‐Cholera Toxin Bind Specifically to Embryonic Chick Dorsal Root Ganglion Neurons but Do Not Modulate Neurite Regeneration

1987 • 38 citations

Reduction of anterograde degeneration in brain damaged rats by GM1-gangliosides

1987 • 37 citations

Treatment of denervated muscle by gangliosides

1979 • 36 citations

Inhibition of conditioned media-mediated neuritogenesis of sensory ganglia by monoclonal antibodies to GM1 ganglioside

1988 • 35 citations

Biotransducers of Membrane‐Mediated Information

1979 • 34 citations

Administration of GM1 ganglioside eliminates neuroleptic-induced sensorimotor deficits in MPTP-treated mice

1988 • 34 citations

Impaired axonal transport of acetylcholinesterase in the sciatic nerve of alloxan-diabetic rats: effect of ganglioside treatment

1986 • 32 citations

Ganglioside treatment of vincristine-induced neuropathy. An electrophysiologic study

1988 • 31 citations

Exogenous GM1 gangliosides protect against retrograde degeneration following posterior neocortex lesions in developing hamsters

1988 • 30 citations

Comparison of the Interaction of Mono- and Oligovalent Ligands with Cholera Toxin. Demonstration of Aggregate Formation at Low Ligand Concentrations

1978 • 29 citations

Intracellular recording and HRP-staining of cortical neurons in feline ganglioside storage disease

1980 • 28 citations

ATPase activity defects in alloxan-induced diabetic sciatic nerve recovered by ganglioside treatment

1988 • 27 citations

GM1 ganglioside attenuates the behavioral deficits but not the granule cell damage produced by intradentate colchicine

1989 • 25 citations

Oligosaccharide Portion of GM1 Enhances Process Formation by S20Y Neuroblastoma Cells

1988 • 24 citations

Stimulation of neurite outgrowth in vitro by a glycero‐ganglioside

1988 • 22 citations

Altered Expression of the D1.1 Ganglioside in the Cerebellum of the Weaver Mouse

1988 • 20 citations

Enhanced sprouting of retinotectal fibers after early superior colliculus lesions in hamsters treated with gangliosides

1988 • 19 citations

The GM1 ganglioside hastens the reduction of hyperemotionality after septal lesions

1987 • 19 citations

Metabolism of Exogenous Gangliosides GM1 and Chemically Modified GM1 in Mice1

1988 • 19 citations

Effects of exogenous G_M1 and G_D1a on S20Y neuroblastoma cells

1984 • 16 citations

Specific gangliosides function as host cell receptors for Sendai virus

1982 • 16 citations

Nerve regeneration in exogenous cerebral ganglioside‐treated rats

1984 • 15 citations

Murine Neuroblastoma Cells Express Ganglioside Binding Sites on Their Cell Surface

1990 • 15 citations

Ganglioside potentiation of NGF‐independent conditioned medium enhancement of neuritic outgrowth from spinal cord and ciliary ganglia explants

1988 • 14 citations

Effect of purkinje cell loss on cerebellar gangliosides in nervous mutant mice

1987 • 12 citations

Gangliosides fail to enhance behavioral recovery after bilateral ablation of the visual cortex

1987 • 11 citations

Retrograde degeneration of basal forebrain cholinergic neurons after neurotoxin lesions of the neocortex: application of ganglioside GM1

1988 • 11 citations

Exogenous gangliosides induce direct voltage and conductance changes on isolated neurons

1988 • 10 citations

Time dependent effect of GM, ganglioside administration upon [3H]5-hydroxytryptamine uptake in partially denervated rat hippocampus

1987 • 10 citations

Gangliosides restore the specificity of afferent projection patterns in spinal cord explants chronically exposed to tetrodotoxin

1986 • 9 citations

Non‐selective afferent innervation develops in embryonic mouse spinal cord‐dorsal root ganglia explants chronically exposed to GM1 ganglioside

1989 • 9 citations

Gangliosides and Neuropathy

1987 • 8 citations

Lesioning and recovery of the serotoninergic hippocampal afferents: Differential effects of GM1 ganglioside

1988 • 7 citations

Effects of ganglioside GM1 on DNA synthesis in isolated nuclei and on the activity of DNA polymerase α derived from S-phase HeLa cells

1988 • 6 citations

Present State of Clinical Experience of Ganglioside Application in Man

1987 • 5 citations

Influence of ganglioside treatment on acrylamide neuropathy in mice. A morphometric study.

1988 • 3 citations

In Vivo Distribution and Metabolism of Exogenous Gangliosides

1987 • 3 citations

Deleted Work

1955 • 0 citations