Treatment with GM1 Ganglioside Restores Striatal Dopamine in the 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Treated Mouse

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

1984 • 1,007 citations

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

1984 • 1,005 citations

Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines.

1966 • 709 citations

Permanent human parkinsonism due to 1‐methy 1–4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)

1985 • 620 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

Gangliosides and membrane receptors for cholera toxin

1973 • 536 citations

Injury-induced neuronotrophic activity in adult rat brain: correlation with survival of delayed implants in the wound cavity

1983 • 389 citations

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

1986 • 347 citations

Biology of gangliosides: Neuritogenic and neuronotrophic properties

1984 • 314 citations

Ganglioside structures and distribution: Are they localized at the nerve ending?

1978 • 307 citations

Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity

1985 • 290 citations

IV. MPTP, MPP+ and mitochondrial function

1987 • 249 citations

Gangliosides in neurological and neuromuscular function, development and repair

1982 • 230 citations

Muscle reinnervation—III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides

1983 • 186 citations

Interactions of G_M1 Ganglioside with Crude Rat Brain Neuronal Membranes

1980 • 146 citations

The stimulating effect of ganglioside injections on the recovery of choline acetyltransferase and acetylcholinesterase activities in the hippocampus of the rat after septal lesions

1982 • 140 citations

Retrograde changes in the nucleus basalis of the rat, caused by cortical damage, are prevented by exogenous ganglioside GM1

1986 • 132 citations

Ganglioside GM₁ Does Not Initiate, but Enhances Neurite Regeneration of Nerve Growth Factor‐Dependent Sensory Neurones

1985 • 121 citations

Epinephrine: A Potential Neurotransmitter in Retina

1983 • 116 citations

1-Methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway

1986 • 111 citations

Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum

1985 • 110 citations

Effects of ganglioside treatment in rats with a lesion of the cholinergic forebrain nuclei

1985 • 93 citations

Effect of GM₁ ganglioside treatment on the recovery of dopaminergic nigro‐striatal neurons after different types of lesion

1984 • 90 citations

Administration of GMI. ganglioside restores the dopamine content in striatum after chronic treatment with MPTP

1986 • 86 citations

GM1 ganglioside enhances regrowth of noradrenaline nerve terminals in rat cerebral cortex lesioned by the neurotoxin 6-hydroxydopamine

1984 • 83 citations

Studies on the Oxidation of the Dopaminergic Neurotoxin 1‐Methyl‐4‐Phenyl‐1,2,5,6‐Tetrahydropyridine by Monoamine Oxidase B

1985 • 83 citations

Sciatic nerve regeneration in ganglioside-treated rats

1982 • 79 citations

Chemical and immunochemical studies on the receptor binding domain of cholera toxin B subunit.

1985 • 79 citations

Parenterally administered GM1 ganglioside prevents retrograde degeneration of cholinergic cells of the rat basal forebrain

1986 • 73 citations

Effect of GM1 ganglioside on neonatally neurotoxin induced degeneration of serotonin neurons in the rat brain

1984 • 61 citations

Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice

1988 • 39 citations

Treatment of denervated muscle by gangliosides

1979 • 36 citations

GM₁ ganglioside counteracts selective neurotoxin‐induced lesion of developing serotonin neurons in rat spinal cord

1986 • 35 citations

Cylindrical spirals in human skeletal muscle

1979 • 34 citations

Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: Modulation by chronic ganglioside GM1 treatment

1985 • 28 citations

Treatment with GM1 ganglioside increases rat spinal cord indole content

1986 • 23 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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