Pronounced and differential effects of ionic strength and pH on testosterone oxidation by membrane-bound and purified forms of rat liver microsomal cytochrome P-450

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or .beta.-naphthoflavone

1982 • 1,021 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

1985 • 593 citations

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 • 576 citations

Interactions of hepatic cytochromes P-450 with steroid hormones

1988 • 441 citations

Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.

1983 • 339 citations

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450

1987 • 330 citations

Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.

1981 • 304 citations

Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats.

1984 • 301 citations

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

1986 • 299 citations

Partial purification of cytochromes P-450 and P-448 from rat liver microsomes

1972 • 270 citations

Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes

1982 • 265 citations

Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.

1980 • 256 citations

Mammalian cytochromes P-450

1987 • 248 citations

On the substrate specificity of cytochrome P450IIIA1.

1988 • 134 citations

Testosterone metabolism by cytochrome P-450 isozymes RLM3 and RLM5 and by microsomes. Metabolite identification.

1983 • 126 citations

Reconstitution of testosterone oxidation by purified rat cytochrome P450p (IIIA1)

1990 • 76 citations

Constitutive Testosterone 6β-Hydroxylase in Rat Liver

1988 • 73 citations

Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes

1988 • 73 citations

An unusual metabolite of testosterone. 17 beta-Hydroxy-4,6-androstadiene-3-one.

1986 • 70 citations

A Sex-Specific Form of Cytochrome P-450 Catalyzing Propoxycoumarin O-Depropylation and Its Identity with Testosterone 6β-Hydroxylase in Untreated Rat Livers: Reconstitution of the Activity with Microsomal Lipids1

1988 • 68 citations

Studies on the pregnenolone-16α-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase

1987 • 63 citations

Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat

1987 • 55 citations

Inhibition of steroid 5α-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450

1988 • 51 citations

Identification of cytochrome P450a (P450IIA1) as the principal testosterone 7α-hydroxylase in rat liver microsomes and its regulation by thyroid hormones

1989 • 51 citations

Isozyme specificity of testosterone 7α-hydroxylation in rat hepatic microsomes: Is cytochrome P-450a the sole catalyst?

1987 • 43 citations

Purification of two isozymes of rat liver microsomal cytochrome P450 with testosterone 7α-hydroxylase activity

1989 • 42 citations

Sexualcharakteristika des Stoffwechsels von Testosteron in der perfundierten Rattenleber

1967 • 41 citations

Studies on the rate-determining factor in testosterone hydroxylation by rat liver microsomal cytochrome P-450: Evidence against cytochrome P-450 isozyme:Isozyme interactions

1987 • 40 citations

Steroid hormones and metabolism

1969 • 38 citations

Mechanism of interaction between cytochromes P-450 RLM5 and b5: Evidence for an electrostatic mechanism involving cytochrome b5 heme propionate groups

1986 • 36 citations

Detection of digoxin, digitoxin, their cardioactive metabolites and derivatives by high-performance liquid chromatography and high-performance liquid chromatography—radioimmunoassay

1986 • 29 citations

The biooxidation of steroids at carbon 6 by isolated perfused rat livers

1954 • 29 citations

The mechanism of cytochrome b5 reduction by NADPH-cytochrome c reductase

1974 • 25 citations

Synthesis of Sex-Specific Forms of Cytochrome P-450 in Rat Liver Is Transiently Suppressed by Hepatic Monooxygenase Inducers

1988 • 18 citations

Digitoxin metabolism by liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase and its role in the protection of rats from digitoxin toxicity by pregnenolone-16α-carbonitrile

1986 • 12 citations