Pharmacogenetic assessment of antipsychotic-induced movement disorders: contribution of the dopamine D3 receptor and cytochrome P450 1A2 genes

Incidence of Adverse Drug Reactions in Hospitalized Patients

1998 • 4,749 citations

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

1999 • 722 citations

Tardive Dyskinesia

1982 • 660 citations

A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.

1996 • 473 citations

Dopamine D3-receptor gene variant and susceptibility to tardive dyskinesia in schizophrenic patients

1997 • 242 citations

Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders

1992 • 241 citations

D3 dopamine receptor mRNA is widely expressed in the human brain

1998 • 237 citations

Proposed Schizophrenia-Related Gene Polymorphism: Expression of the Ser9Gly Mutant Human Dopamine D3Receptor with the Semliki Forest Virus System

1996 • 233 citations

The relationship between paroxetine and the sparteine oxidation polymorphism

1992 • 204 citations

A functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene: association with tardive dyskinesia in schizophrenia

2000 • 169 citations

Association of the MscI Polymorphism of the Dopamine D3 Receptor Gene with Tardive Dyskinesia in Schizophrenia

1999 • 163 citations

Genotypic association between the dopamine D3 receptor and tardive dyskinesia in chronic schizophrenia

1999 • 153 citations

Dopamine Receptor Transcript Expression in Striatum and Prefrontal and Occipital Cortex

1997 • 142 citations

Polymorphic Drug Oxidation

1996 • 141 citations

Regional, reversible ultrastructural changes in rat brain with chronic neuroleptic treatment

1989 • 118 citations

Effects of smoking on fluphenazine clearance in psychiatric inpatients

1985 • 117 citations

Pharmacogenetics of antipsychotic treatment: lessons learned from clozapine

2000 • 94 citations

Biotransformation enzyme polymorphism and pesticide susceptibility.

2000 • 66 citations

Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain

1995 • 64 citations

Cigarette smoking and chlorpromazine disposition and actions

1982 • 46 citations

Chlorpromazine plasma levels, adverse effects, and tobacco smoking: case report.

1983 • 41 citations

Possible genetic factors underlying the pathophysiology of tardive dyskinesia

1994 • 33 citations

Search for a Susceptibility Locus to Tardive Dyskinesia

1997 • 30 citations

The emerging field of ecogenetics.

2000 • 29 citations

Search for a Susceptibility Locus to Tardive Dyskinesia

1997 • 27 citations