Anaerobes: Antibiotic resistance, clinical significance, and the role of susceptibility testing

Update on acquired tetracycline resistance genes

2005 • 915 citations

Guidelines for the Selection of Anti-infective Agents for Complicated Intra-abdominal Infections

2003 • 521 citations

Evidence for Extensive Resistance Gene Transfer among Bacteroides spp. and among Bacteroides and Other Genera in the Human Colon

2001 • 508 citations

Tigecycline: what is it, and where should it be used?

2005 • 264 citations

Multicenter Survey of the Changing In Vitro Antimicrobial Susceptibilities of Clinical Isolates of Bacteroides fragilis Group, Prevotella, Fusobacterium, Porphyromonas , and Peptostreptococcus Species

2001 • 223 citations

Antimicrobial Resistance and Clinical Outcome of Bacteroides Bacteremia: Findings of a Multicenter Prospective Observational Trial

2000 • 209 citations

Antimicrobial Resistance in Anaerobes

1997 • 180 citations

Cloning and sequencing of the class B beta-lactamase gene (ccrA) from Bacteroides fragilis TAL3636

1990 • 173 citations

The role of Bacteroides conjugative transposons in the dissemination of antibiotic resistance genes

2002 • 171 citations

Prevalence of Antibiotic Resistance in Anaerobic Bacteria: Worrisome Developments

2004 • 170 citations

Sequencing the gene for an imipenem-cefoxitin-hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus beta-lactamase II

1990 • 164 citations

Insertion of a novel DNA sequence, IS 1186, upstream of the silent carbapenemase gene cfiA, promotes expression of carbapenem resistance in clinical isolates of Bacteroides fragilis

1994 • 148 citations

Evidence for natural horizontal transfer of tetQ between bacteria that normally colonize humans and bacteria that normally colonize livestock

1994 • 148 citations

Occurrence of the New Tetracycline Resistance Gene tet (W) in Bacteria from the Human Gut

2000 • 132 citations

Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe

2003 • 127 citations

Inducible Metronidazole Resistance and nim Genes in Clinical Bacteroides fragilis Group Isolates

2005 • 116 citations

Genotypic identification of two groups within the species Bacteroides fragilis by ribotyping and by analysis of PCR-generated fragment patterns and insertion sequence content

1995 • 115 citations

gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile

2002 • 114 citations

Multicenter Study of In Vitro Susceptibility of the Bacteroides fragilis Group, 1995 to 1996, with Comparison of Resistance Trends from 1990 to 1996

1999 • 111 citations

National Survey on the Susceptibility ofBacteroides fragilisGroup: Report and Analysis of Trends for 1997–2000

2002 • 108 citations

The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline‐resistance determinants

1994 • 104 citations

Metabolism of a 5-nitroimidazole in susceptible and resistant isogenic strains of Bacteroides fragilis

1997 • 102 citations

Antimicrobial susceptibility of Swedish, Norwegian and Danish isolates of Clostridium perfringens from poultry, and distribution of tetracycline resistance genes

2004 • 100 citations

Genomic analysis of the erythromycin resistance element Tn5398 from Clostridium difficile The GenBank accession number for the Tn5398 element and flanking sequence is AF109075.

2001 • 99 citations

Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases

1993 • 96 citations

Plasmid-Mediated, Transferable Resistance to Clindamycin and Erythromycin in Bacteroides fragilis

1979 • 96 citations

16S Ribosomal DNA Sequence-Based Analysis of Clinically Significant Gram-Positive Anaerobic Cocci

2003 • 95 citations

Clostridium clostridioforme: a mixture of three clinically important species

2005 • 88 citations

Nucleotide sequence analysis of two 5-nitroimidazole resistance determinants from Bacteroides strains and of a new insertion sequence upstream of the two genes

1994 • 87 citations

Surveillance of susceptibility patterns in 1297 European and US anaerobic and capnophilic isolates to co-amoxiclav and five other antimicrobial agents

2004 • 85 citations

Molecular characterization of imipenem-resistant, cfiA-positive Bacteroides fragilis isolates from the USA, Hungary and Kuwait

2004 • 84 citations

Gangrenous and perforated appendicitis with peritonitis: treatment and bacteriology.

1990 • 78 citations

Emergence of fluoroquinolone resistance among Bacteroides species

2003 • 77 citations

The clostridial mobilisable transposons

2002 • 76 citations

A New Bacteroides Conjugative Transposon That Carries an ermB Gene

2003 • 73 citations

Differential gene expression in a Bacteroides fragilis metronidazole-resistant mutant

2004 • 73 citations

Evaluation of the Etest for susceptibility testing of anaerobic bacteria

1995 • 71 citations

Acquired tetracycline and/or macrolide–lincosamides–streptogramin resistance in anaerobes

2003 • 71 citations

Prevalence and association of macrolide-lincosamide- streptogramin B (MLSB) resistance with resistance to moxifloxacin in Clostridium difficile

2003 • 67 citations

New Insertion Sequence Elements in the Upstream Region of cfiA in Imipenem-Resistant Bacteroides fragilis Strains

2003 • 66 citations

Clinical importance ofBilophila wadsworthia

1992 • 65 citations

Bacteroides species highly resistant to metronidazole: an emerging clinical problem?

1999 • 65 citations

Comparative Antianaerobic Activity of BMS 284756

2001 • 64 citations

Plasmids plP419 and plP421 from Bacteroides: 5-nitroimidazole resistance genes and their upstream insertion sequence elements

1995 • 64 citations

Consensus statement on antimicrobial treatment of odontogenic bacterial infections.

2004 • 60 citations

Emergence of penicillin resistance among Fusobacterium nucleatum populations of commensal oral flora during early childhood

2002 • 59 citations

Nitroimidazole resistance genes (nimB) in anaerobic Gram-positive cocci (previously Peptostreptococcus spp.)

2004 • 58 citations

Correlation of various in vitro testing methods with clinical outcomes in patients with Bacteroides fragilis group infections treated with cefoxitin: a retrospective analysis

1992 • 57 citations

Alterations to the penicillin-binding proteins in the Bacteroides fragilis group: a mechanism for non-β-lactamase mediated cefoxitin resistance

1990 • 55 citations

Characterization of beta-lactamases from non-Bacteroides fragilis group Bacteroides spp. belonging to seven species and their role in beta-lactam resistance

1990 • 51 citations

Detection of tetQ and ermF antibiotic resistance genes in Prevotella and Porphyromonas isolates from clinical specimens and resident microbiota of humans

2000 • 49 citations

In Vitro Activity of Gemifloxacin (SB 265805) against Anaerobes

1999 • 49 citations

Antibiotic susceptibilities of Gram-positive anaerobic cocci: results of a sentinel study in England and Wales

2003 • 49 citations

Detection and characterization of β-lactamase genes in subgingival bacteria from patients with refractory periodontitis

2004 • 48 citations

Isolation of Metronidazole-Resistant Bacteroides fragilis Carrying the nimA Nitroreductase Gene from a Patient in Washington State

2004 • 48 citations

β-Lactamase Production in Prevotella intermedia , Prevotella nigrescens , and Prevotella pallens Genotypes and In Vitro Susceptibilities to Selected Antimicrobial Agents

1999 • 46 citations

In Vitro Susceptibility of Anaerobes to Quinolones in the United States

1996 • 44 citations

In vitro activity of 15 antimicrobial agents against clinical isolates of Clostridium difficile in Kuwait

2002 • 42 citations

The erythromycin resistance gene from the Bacteroides conjugal transposon Tcr Emr 7853 is nearly identical to ermG from Bacillus sphaericus

1996 • 41 citations

Role of Topoisomerase Mutations and Efflux in Fluoroquinolone Resistance of Bacteroides fragilis Clinical Isolates and Laboratory Mutants

2004 • 40 citations

Variation in the Susceptibility of Bacteroides fragilis Group Isolates from Six Chicago Hospitals

1993 • 40 citations

Antimicrobial susceptibility of non-Bacteroides fragilis group anaerobic Gram-negative bacilli in Europe

1999 • 38 citations

Outer‐Membrane Pore‐Forming Proteins in Gram‐Negative Anaerobic Bacteria

2002 • 38 citations

Sources and Antimicrobial Susceptibilities of Campylobacter gracilis andSutterella wadsworthensis

1997 • 38 citations

Sequence analysis of cfxA2-like beta-lactamases in Prevotella species

2003 • 38 citations

In Vitro Activities of Faropenem against 579 Strains of Anaerobic Bacteria

2002 • 37 citations

Activities of Gemifloxacin (SB 265805, LB20304) Compared to Those of Other Oral Antimicrobial Agents against Unusual Anaerobes

1999 • 37 citations

Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones

2003 • 36 citations

Alterations in DNA Gyrase and Topoisomerase IV in Resistant Mutants of Clostridium perfringens Found after In Vitro Treatment with Fluoroquinolones

2005 • 33 citations

Nitrate tolerance: hemodynamic effects of intravenous isosorbide dinitrate after sustained oral isosorbide dinitrate administration.

1990 • 33 citations

Trends in Antimicrobial Resistance among Clinical Isolates of the Bacteroides fragilis Group from 1992 to 1997 in Montreal, Canada

1999 • 33 citations

Susceptibility of Anaerobic Bacteria to β-Lactam Antibiotics in the United States

1993 • 32 citations

Risk factors and mortality associated with Clostridium difficile-associated diarrhoea at a VA hospital

2004 • 31 citations

Mechanism of quinolone resistance in anaerobic bacteria

2003 • 30 citations

Mobile Genetic Elements of Fusobacterium nucleatum

1995 • 29 citations

Resistance of anaerobic bacteria to antimicrobial agents in Spain

1992 • 29 citations

Clindamycin Resistance in the Bacteroides fragilis Group: Association with Hospital-Acquired Infections

1997 • 28 citations

Activities of Garenoxacin (BMS-284756) and Other Agents against Anaerobic Clinical Isolates

2003 • 25 citations

Comparative Activity of Eighteen Antimicrobial Agents against Anaerobic Bacteria Isolated in South Africa

1999 • 25 citations

Antibiotic Resistance Among Anaerobes: What Does it Mean?

1999 • 24 citations

United States National Hospital Survey of Anaerobic Culture and Susceptibility Methods, II

1995 • 24 citations

Efflux-Mediated Fluoroquinolone Resistance in the Bacteroides fragilis Group

2002 • 23 citations

Selection of Cefoxitin‐ResistantBacteroides thetaiotaomicronMutants and Mechanisms Involved in β‐Lactam Resistance

2002 • 23 citations

Comparative in vitro activities of ertapenem against bacterial pathogens from patients with acute pelvic infection

2002 • 23 citations

Identification of Essential Residues in the Erm(B) rRNA Methyltransferase ofClostridium perfringens

2002 • 23 citations

Resistance determinants in strains of Clostridium difficile from two geographically distinct populations

2004 • 22 citations

Evolution of Anaerobe Susceptibility Testing in the United States

2002 • 20 citations

Bactericidal Activity of Selected Antimicrobial Agents Against Bilophila wadsworthia and Bacteroides gracilis

1993 • 18 citations

Clinical importance of cefoxitin-resistant Bacteroides fragilis isolates

1987 • 14 citations

Effect of Choice of Medium on the Results of In Vitro Susceptibility Testing of Eight Antibiotics Against the Bacteroides fragilis Group

1995 • 12 citations

Trends in Antimicrobial Resistance of the Bacteroides fragilis Group: A 20‐Year Study at a Medical Center in Buenos Aires, Argentina.

1997 • 10 citations

Susceptibility of anaerobic bacteria in Auckland: 1991-1996.

1999 • 8 citations