Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association

Cochrane Database of Systematic Reviews

2003 • 7,339 citations

Inflammation and Alzheimer's disease

2000 • 4,315 citations

Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease

2002 • 3,568 citations

Diet and Lifestyle Recommendations Revision 2006

2006 • 2,727 citations

Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention

2007 • 2,208 citations

The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

1989 • 1,951 citations

Mixed brain pathologies account for most dementia cases in community-dwelling older persons

2007 • 1,695 citations

Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction

2002 • 1,317 citations

Cardiovascular Effects of n-3 Fatty Acids

1988 • 1,185 citations

Frequent Amyloid Deposition Without Significant Cognitive Impairment Among the Elderly

2008 • 1,004 citations

HEALTH BENEFITS OF DOCOSAHEXAENOIC ACID (DHA)

1999 • 997 citations

n−3 Fatty acids from fish or fish-oil supplements, but not α-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review

2006 • 989 citations

The Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline

2004 • 981 citations

Dietary fat intake and the risk of incident dementia in the Rotterdam study

1997 • 873 citations

Dietary (n-3) Fatty Acids and Brain Development1

2007 • 847 citations

ω-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study

2006 • 717 citations

Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review

2006 • 683 citations

Dietary patterns and risk of dementia

2007 • 667 citations

Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease

2006 • 647 citations

Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment

2000 • 520 citations

Dietary intake of fatty acids and fish in relation to cognitive performance at middle age

2004 • 517 citations

Dietary Fats and the Risk of Incident Alzheimer Disease

2003 • 505 citations

Fish, meat, and risk of dementia: cohort study

2002 • 482 citations

Fish Consumption and Cognitive Decline With Age in a Large Community Study

2005 • 417 citations

Omega-3 fatty acids and monoamine neurotransmission

2006 • 417 citations

Is docosahexaenoic acid, an n−3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals

2005 • 414 citations

Is docosahexaenoic acid, an n−3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals

2005 • 392 citations

Essential Fatty Acids - A Review

2006 • 389 citations

Nutrition in Brain Development and Aging: Role of Essential Fatty Acids

2006 • 383 citations

Benefits of fatty fish on dementia risk are stronger for those without APOE ε4

2005 • 378 citations

Fish Consumption and Incidence of Stroke

2004 • 364 citations

Relation of cognitive activity to risk of developing Alzheimer disease

2007 • 364 citations

Effect of fish oil on cognitive performance in older subjects

2008 • 360 citations

Fish consumption, n−3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study

2007 • 353 citations

Cognitive decline and fatty acid composition of erythrocyte membranes—The EVA Study

2003 • 349 citations

Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors

2006 • 343 citations

Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys.

1990 • 335 citations

Diet and risk of dementia: Does fat matter?

2002 • 325 citations

Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study

2003 • 311 citations

Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction

2006 • 310 citations

Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats

1999 • 305 citations

A role for direct interactions in the modulation of rhodopsin by ω-3 polyunsaturated lipids

2006 • 294 citations

Modulation of Inflammation and Cytokine Production by Dietary (n-3) Fatty Acids

1996 • 260 citations

Chronic distress and incidence of mild cognitive impairment

2007 • 258 citations

Docosahexaenoic acid affects cell signaling by altering lipid rafts

2005 • 256 citations

Polyunsaturated fatty acids and inflammatory diseases

2002 • 251 citations

Effect of infarcts on dementia in the Baltimore longitudinal study of aging

2008 • 217 citations

Prevention of Alzheimer's disease: Omega-3 fatty acid and phenolic anti-oxidant interventions

2005 • 216 citations

Long-chain n–3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men

2005 • 200 citations

Maternal Dietary (n-3) Fatty Acid Deficiency Alters Neurogenesis in the Embryonic Rat Brain

2006 • 196 citations

Long-chain n–3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men

2005 • 195 citations

Effects of altering the ratio of dietary n−6 to n−3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45–70 y: the OPTILIP Study

2006 • 189 citations

Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk

2008 • 174 citations

n–3 Fatty acid erythrocyte membrane content, APOE ε4, and cognitive variation: an observational follow-up study in late adulthood

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The omega-6/omega-3 ratio and cardiovascular disease risk: Uses and abuses

2006 • 149 citations

Omega-3 fatty acids and risk of cognitive impairment and dementia

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Omega 3 fatty acid for the prevention of dementia

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Essential Fatty Acids Preparation (Sr-3) Improves Alzheimer's Patients Quality of Life

1996 • 137 citations

Prostaglandin E precursor fatty acids inhibit human IL-2 production by a prostaglandin E-independent mechanism

1990 • 134 citations

UK Food Standards Agency Workshop Report: the effects of the dietaryn-6:n-3 fatty acid ratio on cardiovascular health

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Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases

1999 • 109 citations

Age-associated changes in central nervous system glycerolipid composition and metabolism.

2002 • 107 citations

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults

2008 • 98 citations

Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys

2000 • 94 citations

Influence of nutrition on cognitive function in a group of elderly, independently living people

2003 • 88 citations

Rectal Diazepam Gel for Treatment of Acute Repetitive Seizures in Adults

2002 • 79 citations

Oral administration of unsaturated fatty acids: effects on human peripheral blood T lymphocyte proliferation

1997 • 75 citations

Erythrocyte membrane characteristics indicate abnormal cellular aging in patients with Alzheimer's disease

1991 • 72 citations

Neutrophil migration inhibitory properties of polyunsaturated fatty acids. The role of fatty acid structure, metabolism, and possible second messenger systems.

1994 • 68 citations

The metabolic syndrome, inflammation, and risk of cognitive decline

2005 • 58 citations

Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo.

1999 • 56 citations

Erythrocyte Membranes 2

1982 • 56 citations

Similarities and Differences between Alzheimer's Disease and Vascular Dementia from the Viewpoint of Nutrition

2002 • 55 citations

A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]

2006 • 48 citations

Nutrition and Immunity: The Immunoregulatory Effect of n-6 Essential Fatty Acids Is Mediated through Prostaglandin E

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Effect of long-term administration of ethyl eicosapentate (EPA-E) on local cerebral blood flow and glucose utilization in stroke-prone spontaneously hypertensive rats (SHRSP)

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Essential Fatty Acids in Alzheimer's Diseasea

1991 • 30 citations

The omega-6/omega-3 ratio and cardiovascular disease risk: Uses and abuses

2007 • 29 citations

Botanical Lipids: Potential Role in Modulation of Immunologic Responses and Inflammatory Reactions

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HypothesisThe Beneficial and Detrimental Effects of Linoleic Acid on Autoimmune Disorders

2003 • 24 citations

Cognitive functions are not affected by dietary fatty acids in elderly subjects in the Pro.V.A. study population

2003 • 22 citations