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Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies

Data up to Jan 2025

Published2002
Citations810
References143
Clinical Trials (1)

Total Citations Per Year

Abstract

References (143)

Bias in meta-analysis detected by a simple, graphical test

1997 • 47,526 citations

Meta-analysis in clinical trials

1986 • 36,193 citations

A RATING SCALE FOR DEPRESSION

1960 • 30,921 citations

A New Depression Scale Designed to be Sensitive to Change

1979 • 12,729 citations

Practical Statistics for Medical Research.

1992 • 12,008 citations

Practical Statistics for Medical Research.

1992 • 5,039 citations

Evidence-Based Health Policy—Lessons from the Global Burden of Disease Study

1996 • 2,165 citations

The use of analogue scales in rating subjective feelings

1974 • 1,960 citations

Tryptophan depletion causes a rapid lowering of mood in normal males

1985 • 726 citations

Major Depressive Disorder

2000 • 543 citations

Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized clinical trial

1998 • 528 citations

Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines

2000 • 422 citations

Relapse of depression after rapid depletion of tryptophan

1997 • 421 citations

Monoamine dysfunction and the pathophysiology and treatment of depression.

1998 • 341 citations

Mood-Lowering Effect of Tryptophan Depletion

1994 • 339 citations

Tryptophan depletion in normal volunteers produces selective impairments in learning and memory

1994 • 312 citations

Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action

1999 • 306 citations

Serotonin and the Neurobiology of Depression

1994 • 286 citations

Tryptophan depletion and its implications for psychiatry

2001 • 278 citations

Covariation of Activity in Habenula and Dorsal Raphé Nuclei Following Tryptophan Depletion

1999 • 277 citations

Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse

1997 • 275 citations

Neural and Behavioral Responses to Tryptophan Depletion in UnmedicatedPatients With Remitted Major Depressive Disorder and Controls

2004 • 264 citations

Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients

1976 • 263 citations

The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers

2002 • 252 citations

Clinical guidelines for the treatment of depressive disorders.

2001 • 247 citations

Mood Response to Acute Tryptophan Depletion in Healthy Volunteers: Sex Differences and Temporal Stability

1996 • 243 citations

Monoamine depletion in psychiatric and healthy populations: review

2003 • 240 citations

Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers

2000 • 229 citations

Association Between Serotonin Transporter Gene Promoter Polymorphism(5HTTLPR) and Behavioral Responses to Tryptophan Depletion in Healthy Women With and Without Family History of Depression

2002 • 220 citations

Meta‐analysis combining parallel and cross‐over clinical trials. I: Continuous outcomes

2002 • 214 citations

Serotonergic Modulation of Prefrontal Cortex during Negative Feedback in Probabilistic Reversal Learning

2005 • 206 citations

Clinical and Physiological Consequences of Rapid Tryptophan Depletion

2000 • 206 citations

Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression.

1991 • 191 citations

Clinical guidelines for the treatment of depressive disorders. IV. Medications and other biological treatments.

2001 • 187 citations

Predictors of Mood Response to Acute Tryptophan Depletion A Reanalysis

2002 • 182 citations

Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study

2004 • 182 citations

Rapid depletion of plasma tryptophan: a review of studies and experimental methodology

1997 • 178 citations

The effects of tryptophan depletion on mood and psychiatric symptoms

2001 • 178 citations

Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI

2005 • 171 citations

Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study

2004 • 160 citations

Differential Effects of 5-HTTLPR Genotypes on the Behavioral and Neural Responses to Tryptophan Depletion in Patients With Major Depression and Controls

2006 • 159 citations

Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants.

1993 • 158 citations

Tyrosine depletion attenuates dopamine function in healthy volunteers

2001 • 158 citations

Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces

2005 • 157 citations

Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients.

1975 • 156 citations

Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism

2002 • 156 citations

Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms

2005 • 154 citations

Mood effects of 24-hour tryptophan depletion in healthy first-degree relatives of patients with affective disorders

1999 • 141 citations

Beyond the monoamine hypothesis: mechanisms, molecules and methods

2002 • 138 citations

Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion

1999 • 134 citations

Acute Tryptophan Depletion. Part I: Rationale and Methodology

2005 • 126 citations

The effects of tyrosine depletion in normal healthy volunteers: implications for unipolar depression

2004 • 124 citations

Regional Brain Metabolic Correlates of α-Methylparatyrosine–Induced Depressive Symptoms

2003 • 123 citations

A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males

1987 • 122 citations

Transient Depressive Relapse Induced by Catecholamine Depletion

1999 • 119 citations

Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.

2004 • 118 citations

Neuro-Psychopharmacology

1962 • 114 citations

Effects on Mood of Acute Phenylalanine/Tyrosine Depletion in Healthy Women

2000 • 113 citations

Tryptophan depletion and depressive vulnerability

1999 • 111 citations

Predictive value of pharmacological activity for the relative efficacy of antidepressant drugs

2000 • 108 citations

Tryptophan, mood, and cognitive function

2002 • 108 citations

Selective Effects of Acute Serotonin and Catecholamine Depletion on Memory in Healthy Women

2004 • 107 citations

Acute tryptophan depletion blocks morphine analgesia in the cold-pressor test in humans

1992 • 104 citations

The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients

2005 • 103 citations

Acute Tryptophan Depletion. Part II: Clinical Effects and Implications

2005 • 101 citations

Benefits from mianserin augmentation of fluoxetine in patients with major depression non‐responders to fluoxetine alone

2001 • 97 citations

Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers

2001 • 95 citations

Effect of acute tryptophan depletion on CO2-induced anxiety in patients with panic disorder and normal volunteers

2000 • 94 citations

Tryptophan Depletion Affects Heart Rate Variability and Impulsivity in Remitted Depressed Patients with a History of Suicidal Ideation

2006 • 93 citations

Effects of Tryptophan Depletion on the Serotonin Transporter in Healthy Humans

2005 • 90 citations

The Subjective and Cognitive Effects of Acute Phenylalanine and Tyrosine Depletion in Patients Recovered from Depression

2005 • 88 citations

How antidepressants help depression: mechanisms of action and clinical response.

2004 • 86 citations

Mood congruent memory bias induced by tryptophan depletion

2002 • 85 citations

Effects of a Tryptophan-Free Amino Acid Drink Challenge on Normal Human Sleep Electroencephalogram and Mood

1998 • 83 citations

Effects of rapid tryptophan depletion on brain 5-HT2receptors: a PET study

2001 • 83 citations

Tryptophan depletion and risk of depression relapse: a prospective study of tryptophan depletion as a potential predictor of depressive episodes

2000 • 81 citations

The effect of acute tryptophan depletion on the BOLD response during performance monitoring and response inhibition in healthy male volunteers

2006 • 81 citations

Specificity of the tryptophan depletion method

1999 • 79 citations

Acute tryptophan depletion and increased food intake and irritability in bulimia nervosa

1995 • 78 citations

Impact of Experimentally Induced Serotonin Deficiency by Tryptophan Depletion on Sleep EEG in Healthy Subjects

1998 • 77 citations

Serotonergic modulation of mismatch negativity

2005 • 76 citations

Lack of behavioral effects of monoamine depletion in healthy subjects

1997 • 76 citations

Acute tryptophan depletion in bulimia: Effects on large neutral amino acids

1994 • 75 citations

Acute tryptophan depletion

1992 • 73 citations

Tryptophan depletion in SSRI-recovered depressed outpatients

2001 • 72 citations

Rapid Tryptophan Depletion, Sleep Electroencephalogram, and Mood in Men With Remitted Depression on Serotonin Reuptake Inhibitors

1998 • 71 citations

Monoamine depletion studies: implications for antidepressant discontinuation syndrome.

2006 • 69 citations

Anterior Cingulate and Subgenual Prefrontal Blood Flow Changes Following Tryptophan Depletion in Healthy Males

2006 • 68 citations

Acute tryptophan depletion improves performance and modulates the BOLD response during a Stroop task in healthy females

2006 • 68 citations

Effects of tryptophan depletion on brain potential correlates of episodic memory retrieval

2002 • 66 citations

Effects of α-Methyl-Para-Tyrosine (AMPT) in Drug-Free Depressed Patients

1996 • 65 citations

Effects of fluoxetine administration on mood response to tryptophan depletion in healthy subjects

1997 • 64 citations

Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature

2006 • 62 citations

Effects of acute tryptophan depletion on executive function in healthy male volunteers

2003 • 62 citations

Rapid Tryptophan Depletion Improves Decision-Making Cognition in Healthy Humans without Affecting Reversal Learning or Set Shifting

2005 • 62 citations

The Effects of Acute Tryptophan Depletion on Neuropsychological Function

2003 • 61 citations

Benefits from mianserin augmentation of fluoxetine in patients with major depression non-responders to fluoxetine alone

2001 • 60 citations

Effect of acute tryptophan depletion on behavioral, cardiovascular, and hormonal sensitivity to cholecystokinin-tetrapeptide challenge in healthy volunteers

1996 • 60 citations

The Neurobiology of Tryptophan Depletion in Depression: Effects of Intravenous Tryptophan Infusion

1998 • 59 citations

Decrease in plasma phenylalanine and tyrosine after phenylalanine-tyrosine free amino acid solutions in man

1996 • 59 citations

The effect of acute tryptophan depletion and fenfluramine on quantitative EEG and mood in healthy male subjects

1999 • 59 citations

Serotonergic‘vulnerability’ in affective disorder: a study of the tryptophan depletion test and relationships between peripheral and central serotonin indexes in citalopram‐responders

1998 • 58 citations

Effect of Tryptophan Depletion on Mood in Male and Female Volunteers: A Pilot Study

1997 • 57 citations

Evidence Report: Treatment of Depression - Newer Pharmacotherapies

1999 • 57 citations

Comparison of the effects of a-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo

1999 • 53 citations

Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion?

2002 • 53 citations

Monoamine depletion in unmedicated depressed subjects

2002 • 50 citations

Estradiol and Tryptophan Depletion Interact to Modulate Cognition in Menopausal Women

2006 • 47 citations

Effect of acute tryptophan depletion on mood and appetite in healthy female volunteers

1994 • 46 citations

Neurobiology of Tryptophan Depletion in Depression: Effects of m-Chlorophenylpiperazine (mCPP)

1997 • 46 citations

Acute tryptophan depletion in healthy young women with a family history of major affective disorder

1999 • 45 citations

Neuropsychological investigation into the carcinoid syndrome

2003 • 45 citations

Acute tryptophan depletion reduces activation in the right hippocampus during encoding in an episodic memory task

2006 • 44 citations

Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor–treated depression: An [18F] MPPF positron emission tomography study

2004 • 42 citations

Effect of acute tryptophan depletion on pre-frontal engagement

2006 • 42 citations

Behavioural effects of acute tryptophan depletion in healthy male volunteers

2000 • 40 citations

Effect of acute tryptophan depletion on the response to controllable and uncontrollable noise stress

2004 • 39 citations

Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants

2004 • 36 citations

Effects of Catecholamine Depletion on Alertness and Mood in Rested and Sleep Deprived Normal Volunteers

1993 • 36 citations

Psychomotor, subjective and neuroendocrine effects of acute tryptophan depletion in the healthy volunteer

1990 • 36 citations

Lack of behavioural effects after acute tyrosine depletion in healthy volunteers

2005 • 36 citations

Rapid tryptophan depletion reverses phenelzine‐induced suppression of REM sleep

2003 • 33 citations

The Effects of L-Dihydroxyphenylalanine on Alertness and Mood in α-Methyl-Para-Tyrosine-Treated Healthy Humans Further Evidence for the Role of Catecholamines in Arousal and Anxiety

1995 • 32 citations

Behavioural effects of acute phenylalanine and tyrosine depletion in healthy male volunteers

2002 • 29 citations

Influence of acute tryptophan depletion on mood and immune measures in healthy males

1999 • 25 citations

Effects of Rapid Tryptophan Depletion on Sleep Electroencephalogram and Mood in Subjects with Partially Remitted Depression on Bupropion

2002 • 25 citations

Lack of Effect of Tyrosine Depletion on Mood in Recovered Depressed Women

2005 • 25 citations

Acute tryptophan depletion in depressed patients treated with a selective serotonin–noradrenalin reuptake inhibitor: Augmentation of antidepressant response?

2005 • 24 citations

Lack of relapse with tryptophan depletion following successful treatment with ECT

1997 • 23 citations

Effects of serotonin and catecholamine depletion on interleukin‐6 activation and mood in human volunteers

2002 • 21 citations

Selective versus multi-transmitter antidepressants: are two mechanisms better than one?

2004 • 21 citations

Neuroticism as a predictor of mood change: The effects of tryptophan depletion

2002 • 20 citations

Mood Changes following Acute Tryptophan Depletion in Healthy Adults

2002 • 19 citations

A Comparison of the Effects of Acute Tryptophan Depletion and Acute Phenylalanine/Tyrosine Depletion in Healthy Women

1999 • 18 citations

Tryptophan depletion

1999 • 17 citations

Selective effects of simultaneous monoamine depletion on mood and emotional responsiveness

2004 • 15 citations

Affective state and EEG sleep profile in response to rapid tryptophan depletion in recently recovered nonmedicated depressed individuals

2004 • 11 citations

The impact of gender on alpha-methyl-paratyrosine mediated changes in prolactin secretion and 6-hydroxymelatonin sulfate excretion

1996 • 10 citations

The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of α-methyl-para-tyrosine

1999 • 10 citations

Time course analysis of para-chlorophenylalanine induced suppression of self-stimulation behavior

1982 • 9 citations

Response to pentagastrin after acute phenylalanine and tyrosine depletion in healthy men: a pilot study.

2001 • 8 citations

A new method for rapidly and simultaneously decreasing serotonin and catecholamine synthesis in humans.

2003 • 7 citations

Deleted Work

1955 • 0 citations

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Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a… (2002) – Molecular Psychiatry | Metascience Observatory Explorer