Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies
Data up to Jan 2025
Total Citations Per Year
Abstract
References (143)
Bias in meta-analysis detected by a simple, graphical test
1997 • 47,526 citations
Meta-analysis in clinical trials
1986 • 36,193 citations
A RATING SCALE FOR DEPRESSION
1960 • 30,921 citations
A New Depression Scale Designed to be Sensitive to Change
1979 • 12,729 citations
Practical Statistics for Medical Research.
1992 • 12,008 citations
Practical Statistics for Medical Research.
1992 • 5,039 citations
Evidence-Based Health Policy—Lessons from the Global Burden of Disease Study
1996 • 2,165 citations
The use of analogue scales in rating subjective feelings
1974 • 1,960 citations
Tryptophan depletion causes a rapid lowering of mood in normal males
1985 • 726 citations
Major Depressive Disorder
2000 • 543 citations
Selective serotonin reuptake inhibitor discontinuation syndrome: a randomized clinical trial
1998 • 528 citations
Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines
2000 • 422 citations
Relapse of depression after rapid depletion of tryptophan
1997 • 421 citations
Monoamine dysfunction and the pathophysiology and treatment of depression.
1998 • 341 citations
Mood-Lowering Effect of Tryptophan Depletion
1994 • 339 citations
Tryptophan depletion in normal volunteers produces selective impairments in learning and memory
1994 • 312 citations
Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action
1999 • 306 citations
Serotonin and the Neurobiology of Depression
1994 • 286 citations
Tryptophan depletion and its implications for psychiatry
2001 • 278 citations
Covariation of Activity in Habenula and Dorsal Raphé Nuclei Following Tryptophan Depletion
1999 • 277 citations
Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Tryptophan Depletion—Induced Depressive Relapse
1997 • 275 citations
Neural and Behavioral Responses to Tryptophan Depletion in UnmedicatedPatients With Remitted Major Depressive Disorder and Controls
2004 • 264 citations
Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed Patients
1976 • 263 citations
The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers
2002 • 252 citations
Clinical guidelines for the treatment of depressive disorders.
2001 • 247 citations
Mood Response to Acute Tryptophan Depletion in Healthy Volunteers: Sex Differences and Temporal Stability
1996 • 243 citations
Monoamine depletion in psychiatric and healthy populations: review
2003 • 240 citations
Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers
2000 • 229 citations
Association Between Serotonin Transporter Gene Promoter Polymorphism(5HTTLPR) and Behavioral Responses to Tryptophan Depletion in Healthy Women With and Without Family History of Depression
2002 • 220 citations
Meta‐analysis combining parallel and cross‐over clinical trials. I: Continuous outcomes
2002 • 214 citations
Serotonergic Modulation of Prefrontal Cortex during Negative Feedback in Probabilistic Reversal Learning
2005 • 206 citations
Clinical and Physiological Consequences of Rapid Tryptophan Depletion
2000 • 206 citations
Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression.
1991 • 191 citations
Clinical guidelines for the treatment of depressive disorders. IV. Medications and other biological treatments.
2001 • 187 citations
Predictors of Mood Response to Acute Tryptophan Depletion A Reanalysis
2002 • 182 citations
Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study
2004 • 182 citations
Rapid depletion of plasma tryptophan: a review of studies and experimental methodology
1997 • 178 citations
The effects of tryptophan depletion on mood and psychiatric symptoms
2001 • 178 citations
Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI
2005 • 171 citations
Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study
2004 • 160 citations
Differential Effects of 5-HTTLPR Genotypes on the Behavioral and Neural Responses to Tryptophan Depletion in Patients With Major Depression and Controls
2006 • 159 citations
Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants.
1993 • 158 citations
Tyrosine depletion attenuates dopamine function in healthy volunteers
2001 • 158 citations
Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces
2005 • 157 citations
Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients.
1975 • 156 citations
Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism
2002 • 156 citations
Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms
2005 • 154 citations
Mood effects of 24-hour tryptophan depletion in healthy first-degree relatives of patients with affective disorders
1999 • 141 citations
Beyond the monoamine hypothesis: mechanisms, molecules and methods
2002 • 138 citations
Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion
1999 • 134 citations
Acute Tryptophan Depletion. Part I: Rationale and Methodology
2005 • 126 citations
The effects of tyrosine depletion in normal healthy volunteers: implications for unipolar depression
2004 • 124 citations
Regional Brain Metabolic Correlates of α-Methylparatyrosine–Induced Depressive Symptoms
2003 • 123 citations
A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males
1987 • 122 citations
Transient Depressive Relapse Induced by Catecholamine Depletion
1999 • 119 citations
Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.
2004 • 118 citations
Neuro-Psychopharmacology
1962 • 114 citations
Effects on Mood of Acute Phenylalanine/Tyrosine Depletion in Healthy Women
2000 • 113 citations
Tryptophan depletion and depressive vulnerability
1999 • 111 citations
Predictive value of pharmacological activity for the relative efficacy of antidepressant drugs
2000 • 108 citations
Tryptophan, mood, and cognitive function
2002 • 108 citations
Selective Effects of Acute Serotonin and Catecholamine Depletion on Memory in Healthy Women
2004 • 107 citations
Acute tryptophan depletion blocks morphine analgesia in the cold-pressor test in humans
1992 • 104 citations
The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients
2005 • 103 citations
Acute Tryptophan Depletion. Part II: Clinical Effects and Implications
2005 • 101 citations
Benefits from mianserin augmentation of fluoxetine in patients with major depression non‐responders to fluoxetine alone
2001 • 97 citations
Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers
2001 • 95 citations
Effect of acute tryptophan depletion on CO2-induced anxiety in patients with panic disorder and normal volunteers
2000 • 94 citations
Tryptophan Depletion Affects Heart Rate Variability and Impulsivity in Remitted Depressed Patients with a History of Suicidal Ideation
2006 • 93 citations
Effects of Tryptophan Depletion on the Serotonin Transporter in Healthy Humans
2005 • 90 citations
The Subjective and Cognitive Effects of Acute Phenylalanine and Tyrosine Depletion in Patients Recovered from Depression
2005 • 88 citations
How antidepressants help depression: mechanisms of action and clinical response.
2004 • 86 citations
Mood congruent memory bias induced by tryptophan depletion
2002 • 85 citations
Effects of a Tryptophan-Free Amino Acid Drink Challenge on Normal Human Sleep Electroencephalogram and Mood
1998 • 83 citations
Effects of rapid tryptophan depletion on brain 5-HT2receptors: a PET study
2001 • 83 citations
Tryptophan depletion and risk of depression relapse: a prospective study of tryptophan depletion as a potential predictor of depressive episodes
2000 • 81 citations
The effect of acute tryptophan depletion on the BOLD response during performance monitoring and response inhibition in healthy male volunteers
2006 • 81 citations
Specificity of the tryptophan depletion method
1999 • 79 citations
Acute tryptophan depletion and increased food intake and irritability in bulimia nervosa
1995 • 78 citations
Impact of Experimentally Induced Serotonin Deficiency by Tryptophan Depletion on Sleep EEG in Healthy Subjects
1998 • 77 citations
Serotonergic modulation of mismatch negativity
2005 • 76 citations
Lack of behavioral effects of monoamine depletion in healthy subjects
1997 • 76 citations
Acute tryptophan depletion in bulimia: Effects on large neutral amino acids
1994 • 75 citations
Acute tryptophan depletion
1992 • 73 citations
Tryptophan depletion in SSRI-recovered depressed outpatients
2001 • 72 citations
Rapid Tryptophan Depletion, Sleep Electroencephalogram, and Mood in Men With Remitted Depression on Serotonin Reuptake Inhibitors
1998 • 71 citations
Monoamine depletion studies: implications for antidepressant discontinuation syndrome.
2006 • 69 citations
Anterior Cingulate and Subgenual Prefrontal Blood Flow Changes Following Tryptophan Depletion in Healthy Males
2006 • 68 citations
Acute tryptophan depletion improves performance and modulates the BOLD response during a Stroop task in healthy females
2006 • 68 citations
Effects of tryptophan depletion on brain potential correlates of episodic memory retrieval
2002 • 66 citations
Effects of α-Methyl-Para-Tyrosine (AMPT) in Drug-Free Depressed Patients
1996 • 65 citations
Effects of fluoxetine administration on mood response to tryptophan depletion in healthy subjects
1997 • 64 citations
Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature
2006 • 62 citations
Effects of acute tryptophan depletion on executive function in healthy male volunteers
2003 • 62 citations
Rapid Tryptophan Depletion Improves Decision-Making Cognition in Healthy Humans without Affecting Reversal Learning or Set Shifting
2005 • 62 citations
The Effects of Acute Tryptophan Depletion on Neuropsychological Function
2003 • 61 citations
Benefits from mianserin augmentation of fluoxetine in patients with major depression non-responders to fluoxetine alone
2001 • 60 citations
Effect of acute tryptophan depletion on behavioral, cardiovascular, and hormonal sensitivity to cholecystokinin-tetrapeptide challenge in healthy volunteers
1996 • 60 citations
The Neurobiology of Tryptophan Depletion in Depression: Effects of Intravenous Tryptophan Infusion
1998 • 59 citations
Decrease in plasma phenylalanine and tyrosine after phenylalanine-tyrosine free amino acid solutions in man
1996 • 59 citations
The effect of acute tryptophan depletion and fenfluramine on quantitative EEG and mood in healthy male subjects
1999 • 59 citations
Serotonergic‘vulnerability’ in affective disorder: a study of the tryptophan depletion test and relationships between peripheral and central serotonin indexes in citalopram‐responders
1998 • 58 citations
Effect of Tryptophan Depletion on Mood in Male and Female Volunteers: A Pilot Study
1997 • 57 citations
Evidence Report: Treatment of Depression - Newer Pharmacotherapies
1999 • 57 citations
Comparison of the effects of a-methyl-p-tyrosine and a tyrosine-free amino acid load on extracellular noradrenaline in the rat hippocampus in vivo
1999 • 53 citations
Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion?
2002 • 53 citations
Monoamine depletion in unmedicated depressed subjects
2002 • 50 citations
Estradiol and Tryptophan Depletion Interact to Modulate Cognition in Menopausal Women
2006 • 47 citations
Effect of acute tryptophan depletion on mood and appetite in healthy female volunteers
1994 • 46 citations
Neurobiology of Tryptophan Depletion in Depression: Effects of m-Chlorophenylpiperazine (mCPP)
1997 • 46 citations
Acute tryptophan depletion in healthy young women with a family history of major affective disorder
1999 • 45 citations
Neuropsychological investigation into the carcinoid syndrome
2003 • 45 citations
Acute tryptophan depletion reduces activation in the right hippocampus during encoding in an episodic memory task
2006 • 44 citations
Tryptophan depletion and serotonin loss in selective serotonin reuptake inhibitor–treated depression: An [18F] MPPF positron emission tomography study
2004 • 42 citations
Effect of acute tryptophan depletion on pre-frontal engagement
2006 • 42 citations
Behavioural effects of acute tryptophan depletion in healthy male volunteers
2000 • 40 citations
Effect of acute tryptophan depletion on the response to controllable and uncontrollable noise stress
2004 • 39 citations
Response to tryptophan depletion in major depression treated with either cognitive therapy or selective serotonin reuptake inhibitor antidepressants
2004 • 36 citations
Effects of Catecholamine Depletion on Alertness and Mood in Rested and Sleep Deprived Normal Volunteers
1993 • 36 citations
Psychomotor, subjective and neuroendocrine effects of acute tryptophan depletion in the healthy volunteer
1990 • 36 citations
Lack of behavioural effects after acute tyrosine depletion in healthy volunteers
2005 • 36 citations
Rapid tryptophan depletion reverses phenelzine‐induced suppression of REM sleep
2003 • 33 citations
The Effects of L-Dihydroxyphenylalanine on Alertness and Mood in α-Methyl-Para-Tyrosine-Treated Healthy Humans Further Evidence for the Role of Catecholamines in Arousal and Anxiety
1995 • 32 citations
Behavioural effects of acute phenylalanine and tyrosine depletion in healthy male volunteers
2002 • 29 citations
Influence of acute tryptophan depletion on mood and immune measures in healthy males
1999 • 25 citations
Effects of Rapid Tryptophan Depletion on Sleep Electroencephalogram and Mood in Subjects with Partially Remitted Depression on Bupropion
2002 • 25 citations
Lack of Effect of Tyrosine Depletion on Mood in Recovered Depressed Women
2005 • 25 citations
Acute tryptophan depletion in depressed patients treated with a selective serotonin–noradrenalin reuptake inhibitor: Augmentation of antidepressant response?
2005 • 24 citations
Lack of relapse with tryptophan depletion following successful treatment with ECT
1997 • 23 citations
Effects of serotonin and catecholamine depletion on interleukin‐6 activation and mood in human volunteers
2002 • 21 citations
Selective versus multi-transmitter antidepressants: are two mechanisms better than one?
2004 • 21 citations
Neuroticism as a predictor of mood change: The effects of tryptophan depletion
2002 • 20 citations
Mood Changes following Acute Tryptophan Depletion in Healthy Adults
2002 • 19 citations
A Comparison of the Effects of Acute Tryptophan Depletion and Acute Phenylalanine/Tyrosine Depletion in Healthy Women
1999 • 18 citations
Tryptophan depletion
1999 • 17 citations
Selective effects of simultaneous monoamine depletion on mood and emotional responsiveness
2004 • 15 citations
Affective state and EEG sleep profile in response to rapid tryptophan depletion in recently recovered nonmedicated depressed individuals
2004 • 11 citations
The impact of gender on alpha-methyl-paratyrosine mediated changes in prolactin secretion and 6-hydroxymelatonin sulfate excretion
1996 • 10 citations
The effect of presynaptic catecholamine depletion on 6-hydroxymelatonin sulfate: a double blind study of α-methyl-para-tyrosine
1999 • 10 citations
Time course analysis of para-chlorophenylalanine induced suppression of self-stimulation behavior
1982 • 9 citations
Response to pentagastrin after acute phenylalanine and tyrosine depletion in healthy men: a pilot study.
2001 • 8 citations
A new method for rapidly and simultaneously decreasing serotonin and catecholamine synthesis in humans.
2003 • 7 citations
Deleted Work
1955 • 0 citations