Crystal structure of porcine cathepsin H determined at 2.1 å resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A Laboratory manual

1989 • 6,833 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

1982 • 1,024 citations

RIBBONS 2.0

1991 • 814 citations

EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY

1997 • 767 citations

The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.

1991 • 595 citations

Structure of papain refined at 1.65 Å resolution

1984 • 508 citations

Proteolytic Activity of Human Osteoclast Cathepsin K

1996 • 494 citations

The refined 2.4 A X-ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.

1990 • 492 citations

Structure of Papain

1968 • 473 citations

INTRACELLULAR PROTEASES

1987 • 460 citations

Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors.

1997 • 446 citations

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

1996 • 379 citations

Binding of chloromethyl ketone substrate analogs to crystalline papain

1976 • 352 citations

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

1992 • 304 citations

Structure of actinidin, after refinement at 1.7 Å resolution

1980 • 287 citations

Role of the Occluding Loop in Cathepsin B Activity

1997 • 258 citations

Homology of amino acid sequences of rat liver cathepsins B and H with that of papain.

1983 • 231 citations

Molecular cloning and gibberellin-induced expression of multiple cysteine proteinases of rice seeds (oryzains).

1991 • 215 citations

Human cathepsin H

1980 • 193 citations

Aleurain: a barley thiol protease closely related to mammalian cathepsin H.

1985 • 187 citations

Crystal structure of cathepsin B inhibited with CA030 at 2.0-.ANG. resolution: A basis for the design of specific epoxysuccinyl inhibitors

1995 • 177 citations

Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

1996 • 170 citations

Human cystatin C. role of the N-terminal segment in the inhibition of human cysteine proteinases and in its inactivation by leucocyte elastase

1991 • 167 citations

The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism

1978 • 159 citations

Crystal structure of a papain-E-64 complex

1989 • 150 citations

Crystallographic studies of carbohydrates

1990 • 144 citations

Cysteine Proteinases and their Inhibitors

1986 • 142 citations

Crystal structures of human procathepsin B at 3.2 and 3.3 Å resolution reveal an interaction motif between a papain‐like cysteine protease and its propeptide

1996 • 139 citations

Oligomeric Structure and Substrate Induced Inhibition of Human Cathepsin C

1995 • 125 citations

The crystal structure of human cathepsin L complexed with E‐64

1997 • 124 citations

Regulation of the Activity of Lysosomal Cysteine Proteinases by pH-Induced Inactivation and/or Endogenous Protein Inhibitors, Cystatins

1995 • 122 citations

Crystal structure of the wild-type human procathepsin B at 2.5 Å resolution reveals the native active site of a papain-like cysteine protease zymogen

1997 • 109 citations

The prosequence of procaricain forms an α-helical domain that prevents access to the substrate-binding cleft

1996 • 107 citations

A Classical Enzyme Active Center Motif Lacks Catalytic Competence until Modulated Electrostatically

1997 • 96 citations

Amino acid sequences of the human kidney cathepsins H and L

1988 • 87 citations

Crystal structure of an actinidin-E-64 complex

1992 • 86 citations

Cysteine proteinases and their inhibitors

1988 • 78 citations

Differences in specificity for the interactions of stefins A, B and D with cysteine proteinases

1996 • 62 citations

Cathepsins B, H and L in human breast carcinoma.

1992 • 61 citations

Determination of the structure of papaya protease omega

1991 • 58 citations

Enzyme-linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera

1997 • 43 citations

Molecular Cloning and Sequencing of a cDNA Coding for Mature Human Kidney Cathepsin H

1988 • 42 citations

Porcine spleen cathepsin H hydrolyzes oligopeptides solely by aminopeptidase activity.

1988 • 40 citations

Endo- and Aminopeptidase Activities of Rat Cathepsin H.

1992 • 38 citations

Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase

1989 • 38 citations

IFN-γ increases cathepsin H mRNA levels in mouse macrophages

1995 • 36 citations

Cathepsins B and H from porcine spleen. Purification, polypeptide chain arrangements, and carbohydrate content.

1984 • 34 citations

The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagents

1989 • 33 citations

Gene structure of rat cathepsin H

1989 • 30 citations

Simultaneous banding of rat embryo DNA, RNA, and protein in cesium trifluoroacetate gradients

1985 • 28 citations

Characterization of a cathepsin‐H‐like enzyme from a human melanoma cell line

1991 • 27 citations

S-S bridges of cathepsin B and H from bovine spleen: a basis for cathepsin B model building and possible functional implications for discrimination between exo- and endopeptidase activities among cathepsins B, H and L.

1991 • 24 citations

Studies on the Aminopeptidase Activity of Rat Cathepsin H

1992 • 23 citations

Inhibition of intracellular sorting and processing of lysosomal cathepsins H and L at reduced temperature in primary cultures of rat hepatocytes

1990 • 20 citations

Protein catabolism in fibroblasts cultured from patients with mucolipidosis II and other lysosomal disorders

1993 • 18 citations

A new purification procedure of human kidney cathepsin H, its properties and kinetic data.

1988 • 15 citations

Human cathepsins B, H and L: characterization by amino acid sequences and some kinetics of inhibition by the kininogens

1986 • 15 citations

Elongation on the Amino‐terminal Part of Stefin B Decreases Inhibition of Cathepsin H

1994 • 14 citations