A p38 MAP kinase inhibitor regulates stability of interleukin‐1‐induced cyclooxygenase‐2 mRNA

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27

1997 • 704 citations

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1997 • 544 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β

1997 • 390 citations

Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Inducible Nitric-oxide Synthase Expression in Mouse Astrocytes

1997 • 300 citations

Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels.

1997 • 288 citations

Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue

1996 • 287 citations

Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway

1998 • 275 citations

Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation

1996 • 235 citations

The p38‐MAPK inhibitor, SB203580, inhibits cardiac stress‐activated protein kinases/c‐Jun N‐terminal kinases (SAPKs/JNKs)

1998 • 224 citations

Serum and Glucocorticoid Regulation of Gene Transcription and Expression of the Prostaglandin H Synthase-1 and Prostaglandin H Synthase-2 Isozymes

1993 • 224 citations

p38 Mitogen-activated Protein Kinase Down-regulates Nitric Oxide and Up-regulates Prostaglandin E2 Biosynthesis Stimulated by Interleukin-1β

1997 • 181 citations

[59] Extraction and thin-layer chromatography of arachidonic acid metabolites

1982 • 162 citations

Phosphorylation and Activation of Cytosolic Phospholipase A₂ by 38‐kDa Mitogen‐Activated Protein Kinase in Collagen‐Stimulated Human Platelets

1997 • 146 citations

Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

1993 • 123 citations

Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha.

1995 • 100 citations

Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.

1997 • 98 citations

Dissociation of Basal Turnover and Cytokine-Induced Transcript Stabilization of the Human Cyclooxygenase-2 mRNA by Mutagenesis of the 3′-Untranslated Region

1998 • 81 citations

Interleukin-1β Induces Cyclooxygenase-2 Gene Expression in Cultured Endometrial Stromal Cells

1998 • 71 citations

Alternate COX-2 Transcripts Are Differentially Regulated: Implications for Post-Transcriptional Control

1997 • 57 citations

Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.

1994 • 51 citations

Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669

1994 • 23 citations

Interleukin-1 Induces Cyclooxygenase-2 Gene Expression in Cultured Endometrial Stromal Cells

1998 • 19 citations

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