Cellular and humoral mediators of pulmonary edema

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

STUDIES ON INFLAMMATION

1961 • 1,539 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

1981 • 1,030 citations

The release of histamine and formation of a slow‐reacting substance (SRS‐A) during anaphylactic shock

1960 • 638 citations

Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.

1980 • 628 citations

Morphological classifications of vertebrate blood capillaries

1959 • 628 citations

Effect of Elevated Left Atrial Pressure and Decreased Plasma Protein Concentration on the Development of Pulmonary Edema

1959 • 555 citations

Pulmonary edema in dogs, especially the sequence of fluid accumulation in lungs.

1967 • 503 citations

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

1984 • 478 citations

The Biology and Pathology of Oxygen Radicals

1978 • 437 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

Free Radicals as Mediators of Tissue Injury

1991 • 386 citations

In vivo damage of rat lungs by oxygen metabolites.

1981 • 360 citations

COMPARISON OF THE ACTIONS OF U‐46619, A PROSTAGLANDIN H₂‐ANALOGUE, WITH THOSE OF PROSTAGLANDIN H₂ AND THROMBOXANE A₂ ON SOME ISOLATED SMOOTH MUSCLE PREPARATIONS

1981 • 356 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

1984 • 322 citations

Formation and actions of leukotrienes

1984 • 320 citations

PHOSPHOLIPASE A₂ ACTIVITY OF GUINEA‐PIG ISOLATED PERFUSED LUNGS: STIMULATION, AND INHIBITION BY ANTI‐INFLAMMATORY STEROIDS

1978 • 310 citations

Inhibition by prostaglandins of leukotriene B4 release from activated neutrophils.

1983 • 308 citations

Nonimmunological Production pf Leukotrienes Induced by Platelet-Activating Factor

1982 • 305 citations

Pulmonary capillary pressure and filtration coefficient in the isolated perfused lung

1967 • 305 citations

Estimation of equivalent pore radii of pulmonary capillary and alveolar membranes

1970 • 278 citations

Leukocytes are required for increased lung microvascular permeability after microembolization in sheep.

1981 • 271 citations

Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.

1982 • 257 citations

Vasoactive properties of acetyl glyceryl ether phosphorylcholine and analogues.

1982 • 250 citations

Neutrophil-endothelial cell interactions. Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro.

1984 • 248 citations

LEUKOTRIENE B₄: A MEDIATOR OF VASCULAR PERMEABILITY

1981 • 247 citations

The effect of leukotrienes C4 and D4 on the microvasculature of guinea-pig skin

1981 • 242 citations

1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants.

1981 • 237 citations

Role of oxygen metabolites in immune complex injury of lung.

1981 • 224 citations

Leukotriene B4: An inflammatory mediator In vivo

1981 • 213 citations

Thromboxane A2 Mediates Augmented Polymorphonuclear Leukocyte Adhesiveness

1980 • 205 citations

Capillary permeability and oedema in the perfused frog

1940 • 197 citations

Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid.

1982 • 196 citations

Platelet‐Activating Factor (PAF‐Acether) Secretion from Platelets: Effect of Aggregating Agents

1980 • 195 citations

The mechanism of action of leukotrienes C4 and D4 in guinea-pig isolated perfused lung and parenchymal strips of guinea pig, rabbit and rat

1981 • 191 citations

Lung injury induced by leukocytic proteases.

1979 • 183 citations

Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor

1982 • 177 citations

Inhibition of polymorphonuclear leukocyte adherence by prostacyclin.

1980 • 177 citations

Neurohemodynamics of Pulmonary Edema

1952 • 174 citations

The microembolism syndrome

1972 • 165 citations

Pulmonary microembolism

1983 • 158 citations

Selective acylation of lyso platelet activating factor by arachidonate in human neutrophils.

1983 • 148 citations

PULMONARY MICROVASCULAR ALTERATIONS AND INJURY INDUCED BY COMPLEMENT FRAGMENTS: SYNERGISTIC EFFECT OF COMPLEMENT ACTIVATION, NEUTROPHIL SEQUESTRATION, AND PROSTAGLANDINS*

1982 • 146 citations

In vitro and in vivo mechanisms of leukotriene-mediated bronchoconstriction in the guinea pig.

1982 • 146 citations

Pulmonary and systemic vasodilator effects of the newly discovered prostaglandin, PGI2

1978 • 145 citations

Granulocyte activation by endotoxin. I. Correlation between adherence and other granulocyte functions, and role of endotoxin structure on biologic activity.

1983 • 145 citations

Histamine and interstitial Pulmonary Edema in the Dog

1971 • 144 citations

Inflammation, Immunity, and Hypersensitivity

1971 • 140 citations

Increased sheep lung vascular permeability caused by histamine.

1975 • 139 citations

Morphologic basis of increased vascular permeability induced by acetyl glyceryl ether phosphorylcholine.

1984 • 123 citations

Interactions between prostaglandins and leukotrienes

1984 • 119 citations

Acute microvascular effects of PAF-acether, as studied by intravital microscopy

1983 • 114 citations

Prostaglandins and the cardiovascular system.

1983 • 113 citations

Neurogenic pulmonary edema.

1984 • 111 citations

Microvascular transport of macromolecules in normal and inflammatory conditions.

1979 • 109 citations

Estimation of effective pulmonary capillary pressure in intact lungs

1983 • 106 citations

Pulmonary endothelial cells.

1977 • 106 citations

THE RELEASE OF PROSTAGLANDINS AND THROMBOXANES FROM GUINEA‐PIG LUNG BY SLOW REACTING SUBSTANCE OF ANAPHYLAXIS, AND ITS INHIBITION

1978 • 98 citations

Mechanisms underlying vasomotor regulation of regional pulmonary blood flow in normal and disease states

1974 • 97 citations

Inhibition of Bradykinin Induced Macromolecular Leakage from Post‐Capillary Venules by a β₂‐Adrenoreceptor Stimulant, Terbutaline

1977 • 94 citations

Pathophysiology of Pulmonary Edema

1985 • 92 citations

Effect of fibrin degradation products on microvascular permeability

1978 • 92 citations

Venous air emboli in sheep: reversible increase in lung microvascular permeability

1981 • 92 citations

Structure elucidation of platelet activating factor derived from human neutrophils

1984 • 91 citations

THE LUNG CIRCULATION

1966 • 90 citations

Effect of pulmonary blood flow on the exchange between the circulating and marginating pool of polymorphonuclear leukocytes in dog lungs.

1982 • 89 citations

Morphological and physiological correlation of bradykinin-induced macromolecular efflux

1979 • 88 citations

Pulmonary vasodilator activity of prostacyclin (PGI2) in the cat.

1979 • 86 citations

Interstitial Fluid Pressure

1968 • 84 citations

Catecholamine response to intracranial hypertension

1978 • 83 citations

Induction of leukocytic infiltrates in rabbit skin by acetyl glyceryl ether phosphorylcholine.

1982 • 82 citations

Micropuncture measurement of lung microvascular pressure during 5-HT infusion

1982 • 82 citations

Superoxide dismutase with heparin prevents increased lung vascular permeability during air emboli in sheep

1983 • 82 citations

Increased pulmonary vascular resistance and permebility due to arachidonate metabolism in isolated rabbit lungs

1982 • 78 citations

The effect of prostacyclin infusion on endotoxin-induced lung injury.

1981 • 77 citations

LEUCOCYTES AND PULMONARY MICROVASCULAR INJURY

1982 • 75 citations

Effect of granulocytopenia on extravascular lung water content after microembolization.

1980 • 74 citations

Mechanism of the serotonin effect on lung transvascular fluid and protein movement in awake sheep.

1975 • 73 citations

THE ROLE OF β‐KECEPTOR AGONISTS IN THE INHIBITION OF PULMONARY EDEMA

1982 • 69 citations

Inhibition of converting enzyme activity by acute hypoxia in dogs

1979 • 68 citations

Isolation of vasoactive peptides from human fibrin and fibrinogen degraded by plasmin

1978 • 68 citations

Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig

1983 • 67 citations

Recent Developments in Pulmonary Edema

1983 • 67 citations

ROLE OF PROSTAGLANDINS IN ACUTE PULMONARY MICROVASCULAR INJURY*

1982 • 66 citations

Pulmonary vasodilator responses to catecholamines and sympathetic nerve stimulation in the cat. Evidence that vascular beta-2 adrenoreceptors are innervated.

1981 • 66 citations

Nervous Control of the Pulmonary Circulation

1980 • 66 citations

Lung fluid and protein exchange during intracranial hypertension and role of sympathetic mechanisms

1980 • 63 citations

Granulocytes mediate the increase in pulmonary vascular permeability after thrombin embolism

1983 • 62 citations

Humoral Control of the Pulmonary Circulation

1980 • 61 citations

Actions of lipoxygenase metabolites in isolated rat lungs

1984 • 59 citations

Prostaglandins and the Lung

1981 • 58 citations

MECHANISMS OF LUNG VASCULAR INJURY AFTER INTRAVASCULAR COAGULATION*

1982 • 58 citations

Platelet function in animals species specificities

1978 • 58 citations

Mechanisms of acute pulmonary dysfunction induced by fibrinogen degradation product D.

1978 • 58 citations

Pulmonary interstitial and capillary pressures estimated from intra-alveolar fluid pressures

1978 • 57 citations

Pulmonary neutrophil kinetics after thrombin-induced intravascular coagulation

1984 • 57 citations

Effect of platelet depletion on lung vascular permeability after microemboli in sheep

1980 • 56 citations

Structure-activity relationships of vasoactive peptides derived from fibrin or fibrinogen degraded by plasmin

1980 • 54 citations

Increased lung vascular permeability after pancreatitis and trypsin infusion.

1982 • 54 citations

Metabolism of leukotrienes B4 and C4 in the isolated perfused rat lung.

1984 • 53 citations

Interstitial Pressure of the Lung

1969 • 52 citations

Steady state pulmonary transvascular water filtration in unanesthetized sheep.

1971 • 51 citations

Analysis of responses to leukotriene D4 in the pulmonary vascular bed.

1984 • 51 citations

Vascular Anti‐permeability Effects of β‐receptor Agonists and Theophylline in the Lung

1979 • 50 citations

TYPES OF PULMONARY MICROVASCULAR INJURY

1982 • 49 citations

Effects of histamine, serotonin, and norepinephrine on circulation of dog lungs

1984 • 49 citations

Thromboxane generation after thrombin. Protective effect of thromboxane synthetase inhibition on lung fluid balance.

1983 • 49 citations

Thrombin-induced Lung Vascular Injury

1983 • 47 citations

Platelets: A Multidisciplinary Approach

1979 • 46 citations

Cardiovascular effects of leukotrienes in neonatal piglets. Role in hypoxic pulmonary vasoconstriction?

1984 • 45 citations

Arachidonate raises vascular resistance but not permeability in lungs of awake sheep

1980 • 44 citations

Isoproterenol and aminophylline reduce lung capillary filtration during high permeability

1979 • 44 citations

Platelet-activating factor (PAF-acether), an activator of neutrophil functions

1982 • 43 citations

Pressure-volume behavior of perivascular interstitium measured in isolated dog lung

1980 • 43 citations

Thrombin-induced alterations in lung fluid balance in awake sheep

1985 • 43 citations

Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites.

1986 • 43 citations

Evaluation of Dose and Route Effects of Platelet Activating Factor-Induced Extravasation in the Guinea Pig

1984 • 43 citations

Effect of acute hypoxia on the pulmonary conversion of angiotensin I to angiotensin II in dogs.

1980 • 42 citations

Activation and control mechanisms of Hageman factor-dependent pathways of coagulation, fibrinolysis, and kinin generation and their contribution to the inflammatory response

1975 • 42 citations

Circulating Catecholamines in Cats Before and After Lethal Head Injury

1979 • 40 citations

Increased pulmonary vascular permeability after bone marrow injection in sheep.

1981 • 40 citations

Lung vascular permeability following progressive pulmonary embolization

1978 • 39 citations

Beta-adrenergic modulation of pulmonary transvascular fluid and protein exchange

1986 • 39 citations

Molecular pathobiology of acetyl glyceryl ether phosphorylcholine: evidence for the structural and functional identity with platelet-activating factor.

1980 • 38 citations

Metabolism of [3H]benzoyl-phenylalanyl-alanyl-proline by pulmonary angiotensin converting enzyme in vivo: effects of bradykinin, SQ 14225 or acute hypoxia.

1981 • 35 citations

ARACHIDONIC ACID, LEUKOTRIENE B₄, AND NEUTROPHIL ACTIVATION*

1983 • 34 citations

Lung fluid balance after pulmonary embolization: effects of thrombin vs. fibrin aggregates

1982 • 33 citations

Role of intravascular coagulation and granulocytes in lung vascular injury after bone marrow embolism.

1982 • 33 citations

Comparative effects of thromboxane B2 on the canine and feline pulmonary vascular bed.

1980 • 33 citations

Antagonism of histamine edema formation by catecholamines

1978 • 32 citations

INTRAVASCULAR PLATELET AGGREGATION AND PULMONARY INJURY

1982 • 31 citations

Platelet-Activating Factor Causes Neutrophil Accumulation and Edema in Rabbit Lungs

1983 • 31 citations

Lung fluid and protein exchange in the acute sheep preparation

1981 • 29 citations

Prevention of increased pulmonary vascular permeability after pancreatitis by granulocyte depletion in sheep.

1982 • 29 citations

Unusual pulmonary vasodilator activity of 13,14-dehydroprostacyclin methyl ester: comparison with endoperoxides and other prostanoids.

1977 • 29 citations

Terbutaline and adrenaline inhibit leakage of fluid and protein in guinea-pig lung

1979 • 29 citations

Increased Permeability Associated with Dilatation of Endothelial Cell Junctions Caused by Histamine in Intimal Explants from Bovine Pulmonary Artery

1984 • 28 citations

Pulmonary microcirculatory responses to leukotrienes B4, C4 and D4 in sheep

1985 • 28 citations

Effects of epinephrine and norepinephrine infusion on lung fluid balance in sheep

1981 • 27 citations

Arachidonic acid aggregates neutrophils

1979 • 27 citations

Effect of pulmonary artery occlusion and reperfusion on extravascular fluid accumulation

1981 • 26 citations

Mechanisms of Acute Lung Injury

1983 • 25 citations

Assessment of Capillary Permeability Using Lymphatic Protein Flux: Estimation of the Osmotic Reflection Coefficient

1981 • 25 citations

Bradykinin-induced increase in pulmonary vascular permeability in hypoxic sheep

1982 • 24 citations

THE PULMONARY INTERSTITIUM IN CAPILLARY EXCHANGE

1982 • 23 citations

Action and metabolism of bradykinin in dog lung.

1973 • 23 citations

Effect of infusing histamine into pulmonary or bronchial artery on sheep pulmonary fluid balance.

1979 • 22 citations

Pulmonary vascular responses to prostaglandins.

1981 • 21 citations

Effect of acute pancreatitis on pulmonary transvascular fluid and protein exchange.

1981 • 21 citations

MECHANISMS OF NEUROGENIC PULMONARY EDEMA*

1982 • 20 citations

Factors affecting lung vascular permeability.

1977 • 20 citations

Effects of cyclooxygenase and lipoxygenase inhibition on lung fluid balance after thrombin

1983 • 20 citations

Aggregation fo blood platelets and increased hydraulic conductivity of pulmonary exchange vessels.

1976 • 20 citations

Role of Thromboxane in the Pulmonary Response to Pulmonary Microembolization

1983 • 19 citations

Intravascular platelet aggregation and acute respiratory insufficiency.

1977 • 19 citations

First annual Lamport award manuscript

1978 • 19 citations

Role of Blood Components in Mediating Lung Vascular Injury after Pulmonary Vascular Thrombosis

1983 • 18 citations

Pulmonary vascular response to thrombin: Effects of thromboxane synthetase inhibition with OKY-046 and OKY-1581

1984 • 17 citations

Pulmonary edema after pancreatitis: role of humoral factors.

1983 • 16 citations

Effect of prostacyclin on pulmonary vascular response to thrombin in awake sheep

1986 • 15 citations

Effects of left atrial pressure elevation and histamine infusion on lung lymph in awake sheep

1984 • 15 citations

Histamine decreases selectivity of sheep lung blood-lymph barrier

1983 • 14 citations

Experimental Leukocyte-Induced Pulmonary Vasculitis with Inquiry into Mechanism

1977 • 13 citations

Haemodynamic changes in adrenaline-induced acute massive lung oedema

1975 • 12 citations

Responses to leukotriene C4 in the perfused rat lung.

1984 • 12 citations

Synthesis and biological activity of some structural analogs of platelet-activating factor (PAF-acether)

1981 • 12 citations

Histamine-induced pulmonary edema distal to pulmonary arterial occlusion

1985 • 11 citations

Action and metabolism of prostaglandins in the pulmonary circulation.

1982 • 11 citations

Pulmonary microvascular response to prostacyclin (PGI2) infusion in unanesthetized sheep

1982 • 10 citations

Effect of ADP-induced platelet aggregation on lung fluid balance in sheep

1982 • 10 citations

Inhibition of cyclooxygenase production does not prevent arachidonate from increasing extravacular lung water and albumin in an isolated dog lung

1984 • 10 citations

Pulmonary vascular responses to histamine in sheep

1983 • 9 citations

Effect of bradykinin on lung vascular permeability in sheep

1983 • 8 citations

The Mechanism of Bradykinin Edema

1970 • 7 citations

Morphological and physiological study of the effect of histamine on the isolated perfused rabbit lung.

1979 • 6 citations

METABOLIC FACTORS AS MEDIATORS OF PULMONARY VASCULAR INJURY*

1982 • 3 citations

Deleted Work

1955 • 0 citations