Pancreas: how to get there from the gut?

Handbook of Physiology.

1960 • 10,428 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

HedgehogandBmpGenes Are Coexpressed at Many Diverse Sites of Cell–Cell Interaction in the Mouse Embryo

1995 • 1,380 citations

Notch signalling controls pancreatic cell differentiation

1999 • 1,147 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein

1995 • 1,028 citations

Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling

1997 • 1,019 citations

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice

1997 • 1,011 citations

Developmental biology of the pancreas

1995 • 942 citations

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

1997 • 779 citations

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

1997 • 776 citations

Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation

1996 • 774 citations

Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling

1999 • 773 citations

neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia

1998 • 731 citations

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

1997 • 690 citations

Notochord repression of endodermal Sonic hedgehog permits pancreas development

1998 • 621 citations

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells

1998 • 616 citations

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

1997 • 567 citations

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

1996 • 548 citations

neurogenins,a Novel Family ofatonal-Related bHLH Transcription Factors, Are Putative Mammalian Neuronal Determination Genes That Reveal Progenitor Cell Heterogeneity in the Developing CNS and PNS

1996 • 536 citations

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

1998 • 531 citations

NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus

1999 • 519 citations

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

1997 • 443 citations

The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons

1998 • 439 citations

Epitheliomesenchymal interaction in pancreatic morphogenesis

1962 • 409 citations

Notochord to endoderm signaling is required for pancreas development

1997 • 408 citations

Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning

1998 • 386 citations

Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9

1999 • 377 citations

Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice

1999 • 351 citations

Specification of Motor Neuron Identity by the MNR2 Homeodomain Protein

1998 • 340 citations

The Neural Crest and the Origin of the Insulin-Producing and Other Gastrointestinal Hormone-Producing Cells

1976 • 335 citations

Early pancreas organogenesis: Morphogenesis, tissue interactions, and mass effects

1967 • 326 citations

The β cell transcription factors and development of the pancreas

1997 • 322 citations

Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development

1998 • 281 citations

Neurogenic genes and vertebrate neurogenesis

1996 • 268 citations

Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor

1998 • 256 citations

Spectrum and Frequency of Jagged1 (JAG1) Mutations in Alagille Syndrome Patients and Their Families

1998 • 226 citations

Notch and Neurogenesis

2018 • 200 citations

On the origin of pancreatic endocrine cells

1988 • 195 citations

Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas

1999 • 189 citations

Analysis of endoderm formation in the avian blastoderm by the use of quail-chick chimaeras. The problem of the neurectodermal origin of the cells of the APUD series.

1977 • 185 citations

The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of split (HES) promoters

1999 • 177 citations

THE DEVELOPMENT OF THE DORSAL AND VENTRAL MAMMALIAN PANCREAS IN VIVO AND IN VITRO

1970 • 125 citations

Pancreas development and diabetes

1999 • 100 citations

A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues.

1994 • 89 citations

Expression of keratinocyte growth factor in embryonic liver of transgenic mice causes changes in epithelial growth and differentiation resulting in polycystic kidneys and other organ malformations.

1996 • 72 citations

Fibroblast growth factor 2 promotes pancreatic epithelial cell proliferation via functional fibroblast growth factor receptors during embryonic life.

1998 • 68 citations