Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures

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Localization of neuronal and glial glutamate transporters

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Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons

1996 • 1,126 citations

Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel ß1 subunit gene SCN1B

1998 • 1,003 citations

Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats

2002 • 986 citations

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1995 • 884 citations

Prevalence of Epilepsy in Rochester, Minnesota: 1940–1980

1991 • 840 citations

Pacemaker Mechanisms in Cardiac Tissue

1993 • 835 citations

Absence Epilepsy in Tottering Mutant Mice Is Associated with Calcium Channel Defects

1996 • 773 citations

The mouse stargazer gene encodes a neuronal Ca2+-channel γ subunit

1998 • 580 citations

Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain

2005 • 573 citations

Lack of the Burst Firing of Thalamocortical Relay Neurons and Resistance to Absence Seizures in Mice Lacking α1G T-Type Ca2+ Channels

2001 • 520 citations

Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats.

2003 • 505 citations

Molecular mechanism of cAMP modulation of HCN pacemaker channels

2001 • 505 citations

Deep Layer Somatosensory Cortical Neurons Initiate Spike-and-Wave Discharges in a Genetic Model of Absence Seizures

2007 • 439 citations

Neuropathological Findings in Primary Generalized Epilepsy: A Study of Eight Cases

1984 • 434 citations

Genetic absence epilepsy in rats from Strasbourg — A review

1992 • 432 citations

Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy

1995 • 418 citations

Mutation of the Ca2+ Channel β Subunit Gene Cchb4 Is Associated with Ataxia and Seizures in the Lethargic (lh) Mouse

1997 • 399 citations

Association between genetic variation of CACNA1H and childhood absence epilepsy

2003 • 373 citations

The HCN Gene Family: Molecular Basis of the Hyperpolarization‐Activated Pacemaker Channels

1999 • 360 citations

SCN1Amutations and epilepsy

2005 • 351 citations

A STUDY OF THALAMIC AND CORTICAL RHYTHMS IN PETIT MAL

1953 • 325 citations

Generalized Cortico‐Reticular Epilepsies Some Considerations on the Pathophysiology of Generalized Bilaterally Synchronous Spike and Wave Discharge

1968 • 285 citations

Navigating the channels and beyond: unravelling the genetics of the epilepsies

2008 • 266 citations

Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain

2000 • 228 citations

The WAG/Rij rat model for absence epilepsy: age and sex factors

1987 • 217 citations

A Model of Chronic Spontaneous Petit Mal‐like Seizures in the Rat: Comparison with Pentylenetetrazol‐Induced Seizures

1984 • 212 citations

Extended spectrum of idiopathic generalized epilepsies associated with CACNA1H functional variants

2007 • 209 citations

Early treatment suppresses the development of spike‐wave epilepsy in a rat model

2007 • 201 citations

Elevated anxiety and depressive-like behavior in a rat model of genetic generalized epilepsy suggesting common causation

2007 • 188 citations

Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model

2006 • 187 citations

Gating Effects of Mutations in the Cav3.2 T-type Calcium Channel Associated with Childhood Absence Epilepsy

2004 • 183 citations

A Ca_v3.2 T-Type Calcium Channel Point Mutation Has Splice-Variant-Specific Effects on Function and Segregates with Seizure Expression in a Polygenic Rat Model of Absence Epilepsy

2009 • 178 citations

An impaired neocortical I_h is associated with enhanced excitability and absence epilepsy

2004 • 174 citations

The role of basal ganglia in the control of generalized absence seizures

1998 • 161 citations

Thalamo–cortical network pathology in idiopathic generalized epilepsy: Insights from MRI-based morphometric correlation analysis

2009 • 158 citations

Mapping of spontaneous spike and wave discharges in Wistar rats with genetic generalized non-convulsive epilepsy

1990 • 156 citations

Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat

2000 • 152 citations

Demonstration of thalarnic activation during typical absence seizures using H ₂ ¹⁵ O and PET

1995 • 151 citations

The genetics of human epilepsy

2003 • 146 citations

Spike-wave discharges and sleep-wake states in rats with absence epilepsy

1991 • 145 citations

Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy

2003 • 137 citations

Regional grey matter abnormalities in juvenile myoclonic epilepsy: A voxel-based morphometry study

2007 • 134 citations

Magnetic resonance spectroscopy and imaging of the thalamus in idiopathic generalized epilepsy

2003 • 131 citations

Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1–4 suggests evolving roles in the developing rat hippocampus

2001 • 128 citations

Dopamine in the striatum modulates seizures in a genetic model of absence epilepsy in the rat

2000 • 128 citations

Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy

2008 • 125 citations

Effects of Ca_v3.2 channel mutations linked to idiopathic generalized epilepsy

2005 • 113 citations

Impaired Regulation of Thalamic Pacemaker Channels through an Imbalance of Subunit Expression in Absence Epilepsy

2005 • 112 citations

Frontal and temporal volumes in Childhood Absence Epilepsy

2009 • 108 citations

Absence epilepsy: advances in experimental animal models.

1999 • 106 citations

Depressive-like behavioral alterations and c-fos expression in the dopaminergic brain regions in WAG/Rij rats with genetic absence epilepsy

2003 • 105 citations

Thalamic Atrophy in Childhood Absence Epilepsy

2006 • 103 citations

Quantitative Analysis and Subcellular Distribution of mRNA and Protein Expression of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels throughout Development in Rat Hippocampus

2006 • 97 citations

Cellular and network mechanisms of genetically-determined absence seizures

2005 • 95 citations

The Mechanism of Carbamazepine Aggravation of Absence Seizures

2006 • 93 citations

DTI abnormalities in anterior corpus callosum of rats with spike–wave epilepsy

2009 • 87 citations

Effects of drugs affecting dopaminergic neurotransmission in rats with spontaneous petit mal-like seizures

1988 • 87 citations

Neuroprotective Activity of Metabotropic Glutamate Receptor Ligands

2003 • 86 citations

Central Benzodiazepine/γ‐Aminobutyric Acid_A Receptors in Idiopathic Generalized Epilepsy: An [₁₁C]Flumazenil Positron Emission Tomography Study

1997 • 85 citations

Neuron Density in the Molecular Layer of the Frontal Cortex in Primary Generalized Epilepsy

1985 • 85 citations

Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy

2010 • 85 citations

Correlation of T-channel coding gene expression, IT, and the low threshold Ca2+ spike in the thalamus of a rat model of absence epilepsy

2008 • 85 citations

Induction of neonatal sodium channel II and III α‐isoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus

2001 • 81 citations

Brain development in children with new onset epilepsy: A prospective controlled cohort investigation

2010 • 76 citations

Changes in the mRNAs encoding subtypes I, II and III sodium channel alpha subunits following kainate-induced seizures in rat brain.

1997 • 75 citations

Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy

2006 • 73 citations

Generalized epilepsy with febrile seizures plus–associated sodium channel β1 subunit mutations severely reduce beta subunit–mediated modulation of sodium channel function

2007 • 67 citations

Behavioral characteristics of WAG/Rij rats susceptible and non-susceptible to audiogenic seizures

2005 • 65 citations

Genes and mutations in human idiopathic epilepsy

2003 • 64 citations

Polygenic Control of Idiopathic Generalized Epilepsy Phenotypes in the Genetic Absence Rats from Strasbourg (GAERS)

2004 • 60 citations

GABAA receptor impairment in the genetic absence epilepsy rats from Strasbourg (GAERS): an immunocytochemical and receptor binding autoradiographic study

1993 • 60 citations

Decreased expression of glutamate transporters in genetic absence epilepsy rats before seizure occurrence

2002 • 60 citations

Molecular cloning and expression of the rat EAAT4 glutamate transporter subtype

1998 • 55 citations

Morphometric abnormalities and hyperanxiety in genetically epileptic rats: A model of psychiatric comorbidity?

2008 • 55 citations

Reduced GABAB receptor subunit expression and paired-pulse depression in a genetic model of absence seizures

2007 • 55 citations

Chromosomal Mapping of Genetic Loci Controlling Absence Epilepsy Phenotypes in the WAG/Rij Rat

2004 • 53 citations

A genetic epilepsy rat model displays endophenotypes of psychosis

2010 • 53 citations

Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures

2007 • 51 citations

Thalamofrontal neurodevelopment in new-onset pediatric idiopathic generalized epilepsy

2010 • 50 citations

Distribution of D1-like and D2-like dopamine receptors in the brain of genetic epileptic WAG/Rij rats

2005 • 48 citations

Glutamatergic alterations in the cortex of genetic absence epilepsy rats

2007 • 43 citations

Morphometric Golgi study of cortical locations in WAG/Rij rats: the cortical focus theory

2004 • 40 citations

Genetics of spike-wave discharges in the electroencephalogram (EEG) of the WAG/Rij inbred rat strain: A classical mendelian crossbreeding study

1992 • 39 citations

[A genetic form of petit mal absence in Wistar rats].

1984 • 37 citations

GABAB-receptor isoforms

2001 • 36 citations

NMDA-NR1 and AMPA-GluR4 receptor subunit immunoreactivities in the absence epileptic WAG/Rij rat

2006 • 35 citations

Up-regulation of D3 dopaminergic receptor mRNA in the core of the nucleus accumbens accompanies the development of seizures in a genetic model of absence-epilepsy in the rat

2001 • 33 citations

A <I>TASK3</I> Channel (<I>KCNK9</I>) Mutation in a Genetic Model of Absence Epilepsy

2005 • 30 citations

Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg

2011 • 29 citations

The GABAA receptor complex in experimental absence seizures in rat: An autoradiographic study

1992 • 28 citations

Aggravation of Absence Seizures by Carbamazepine in a Genetic Rat Model Does Not Induce Neuronal c-Fos Activation

2005 • 28 citations

Neuroactive steroids and GABA_A receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy

2008 • 22 citations

Amygdala volumes in childhood absence epilepsy

2009 • 22 citations

Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin

2008 • 22 citations

Glial glutamate transporter mRNAs in the genetically absence epilepsy rat from Strasbourg

2000 • 19 citations

Changes in the mRNAs encoding subtypes I, II and III sodium channel alpha subunits following kainate-induced seizures in rat brain

1997 • 15 citations

MRI‐based large deformation high dimensional mapping of the hippocampus in rats: Development and validation of the technique

2009 • 5 citations