Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model

The NEURON Simulation Environment

1997 • 2,612 citations

Influence of dendritic structure on firing pattern in model neocortical neurons

1996 • 1,260 citations

Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats

2002 • 986 citations

Childhood absence epilepsy: Genes, channels, neurons and networks

2002 • 637 citations

Action potential initiation and propagation in rat neocortical pyramidal neurons

1997 • 588 citations

Immunohistochemical localization of I_h channel subunits, HCN1–4, in the rat brain

2004 • 544 citations

Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites

1998 • 541 citations

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2

2003 • 521 citations

Genetic animal models for absence epilepsy: a review of the WAG/Rij strain of rats.

2003 • 505 citations

Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites

2002 • 453 citations

Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites

2002 • 448 citations

Burst generating and regular spiking layer 5 pyramidal neurons of rat neocortex have different morphological features

1990 • 438 citations

Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability

2001 • 434 citations

In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons

1999 • 379 citations

Cellular–Synaptic Generation of Sleep Spindles, Spike-and-Wave Discharges, and Evoked Thalamocortical Responses in the Neocortex of the Rat

1997 • 367 citations

Calcium electrogenesis in distal apical dendrites of layer 5 pyramidal cells at a critical frequency of back-propagating action potentials

1999 • 353 citations

Site Independence of EPSP Time Course Is Mediated by DendriticI _h in Neocortical Pyramidal Neurons

2000 • 350 citations

Are “Generalized” Seizures Truly Generalized? Evidence of Localized Mesial Frontal and Frontopolar Discharges in Absence

2004 • 329 citations

Mechanisms and consequences of action potential burst firing in rat neocortical pyramidal neurons

1999 • 303 citations

Seizure-Induced Plasticity of h Channels in Entorhinal Cortical Layer III Pyramidal Neurons

2004 • 285 citations

Spontaneous paroxysmal electroclinical patterns in rat: A model of generalized non-convulsive epilepsy

1982 • 285 citations

Somatosensory Corticothalamic Projections: Distinguishing Drivers From Modulators

2004 • 282 citations

SingleI_hChannels in Pyramidal Neuron Dendrites: Properties, Distribution, and Impact on Action Potential Output

2006 • 258 citations

Thalamic bursting in rats during different awake behavioral states

2001 • 242 citations

Layer-Specific Intracolumnar and Transcolumnar Functional Connectivity of Layer V Pyramidal Cells in Rat Barrel Cortex

2001 • 238 citations

An analysis of penicillin-induced generalized spike and wave discharges using simultaneous recordings of cortical and thalamic single neurons

1983 • 232 citations

The WAG/Rij rat model for absence epilepsy: age and sex factors

1987 • 217 citations

Block of Cloned Human T-Type Calcium Channels by Succinimide Antiepileptic Drugs

2001 • 211 citations

Regulation of HCN Channel Surface Expression by a Novel C-Terminal Protein-Protein Interaction

2004 • 211 citations

Global and focal aspects of absence epilepsy: The contribution of genetic models

2006 • 201 citations

Linking Generalized Spike‐and‐Wave Discharges and Resting State Brain Activity by Using EEG/fMRI in a Patient with Absence Seizures

2006 • 196 citations

Presynaptic Action Potential Amplification by Voltage-Gated Na+ Channels in Hippocampal Mossy Fiber Boutons

2005 • 195 citations

Channelopathies as a genetic cause of epilepsy

2003 • 182 citations

Channelopathies as a genetic cause of epilepsy

2003 • 175 citations

An impaired neocortical I_h is associated with enhanced excitability and absence epilepsy

2004 • 174 citations

Relations between cortical and thalamic cellular activities during absence seizures in rats

1998 • 167 citations

Cortical-area specific block of genetically determined absence seizures by ethosuximide

2003 • 165 citations

Thalamocortical optimization of tactile processing according to behavioral state

2002 • 142 citations

Cellular interactions in the rat somatosensory thalamocortical system during normal and epileptic 5–9 Hz oscillations

2003 • 140 citations

Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy

2003 • 137 citations

Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures

2005 • 127 citations

Hyperpolarization-Activated Current I_h Disconnects Somatic and Dendritic Spike Initiation Zones in Layer V Pyramidal Neurons

2003 • 123 citations

Impaired Regulation of Thalamic Pacemaker Channels through an Imbalance of Subunit Expression in Absence Epilepsy

2005 • 112 citations

Electrophysiological characterization of remote chemical synapses.

1982 • 111 citations

Voltage- and Site-Dependent Control of the Somatic Impact of Dendritic IPSPs

2003 • 108 citations

Quantitative Analysis and Subcellular Distribution of mRNA and Protein Expression of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels throughout Development in Rat Hippocampus

2006 • 97 citations

Cortical hyperpolarization-activated depolarizing current takes part in the generation of focal paroxysmal activities

2002 • 95 citations

Ontogeny of spontaneous petit mal-like seizures in Wistar rats

1986 • 75 citations

Increased Excitability and Inward Rectification in Layer V Cortical Pyramidal Neurons in the Epileptic Mutant MouseStargazer

1997 • 75 citations

Sleep Oscillations Developing into Seizures in Corticothalamic Systems

2003 • 73 citations

Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy

2006 • 73 citations

Corticothalamic 5–9 Hz oscillations are more pro‐epileptogenic than sleep spindles in rats

2006 • 68 citations

Environmental manipulations early in development alter seizure activity, I_h and HCN1 protein expression later in life

2006 • 67 citations

Synaptic hyperexcitability of deep layer neocortical cells in a genetic model of absence seizures

2005 • 60 citations

Molecular and functional analysis of hyperpolarization‐activated pacemaker channels in the hippocampus after entorhinal cortex lesion

2001 • 60 citations

Heterogeneous Integration of Bilateral Whisker Signals by Neurons in Primary Somatosensory Cortex of Awake Rats

2004 • 55 citations

Chromosomal Mapping of Genetic Loci Controlling Absence Epilepsy Phenotypes in the WAG/Rij Rat

2004 • 53 citations

The Yin and Yang of the H-Channel and Its Role in Epilepsy

2004 • 51 citations

Morphometric Golgi study of cortical locations in WAG/Rij rats: the cortical focus theory

2004 • 40 citations

Genetics of spike-wave discharges in the electroencephalogram (EEG) of the WAG/Rij inbred rat strain: A classical mendelian crossbreeding study

1992 • 39 citations

The multiple effects of ketamine on electroencephalographic activity and behavior in WAG/Rij rats

2004 • 17 citations