Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity

2004 • 682 citations

Tim-3 inhibits T helper type 1–mediated auto- and alloimmune responses and promotes immunological tolerance

2003 • 674 citations

SOCS-1 Participates in Negative Regulation of LPS Responses

2002 • 636 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

2003 • 595 citations

Dendritic cell modulation by 1α,25 dihydroxyvitamin D₃and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturityin vitroandin vivo

2001 • 591 citations

Identification of Regulatory T Cells in Tolerated Allografts

2002 • 577 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers

2002 • 477 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

CD4 ⁺ CD25 ⁺ T regulatory cells control anti-islet CD8 ⁺ T cells through TGF-β–TGF-β receptor interactions in type 1 diabetes

2003 • 439 citations

Induction offoxP3+ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants

2004 • 416 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

Cells Expressing Indoleamine 2,3-Dioxygenase Inhibit T Cell Responses

2002 • 344 citations

Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction

2004 • 335 citations

Functional Impairment of CD8+ T Cells by Regulatory T Cells during Persistent Retroviral Infection

2004 • 318 citations

Induction of tolerance in peripheral T cells with monoclonal antibodies

1990 • 285 citations

T Cell Regulation as a Side Effect of Homeostasis and Competition

2003 • 263 citations

CD40 Ligand Blockade Induces CD4+ T Cell Tolerance and Linked Suppression

1999 • 251 citations

T cell suppression in transplantation tolerance through linked recognition.

1996 • 246 citations

Regulating the Immune Response to Transplants

2001 • 242 citations

The complementary roles of deletion and regulation in transplantation tolerance

2003 • 238 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance

2000 • 202 citations

Mixed Chimerism and Transplantation Tolerance

2001 • 184 citations

Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy

2002 • 177 citations

AMPLIFICATION OF NATURAL REGULATORY IMMUNE MECHANISMS FOR TRANSPLANTATION TOLERANCE1

1996 • 161 citations

Dominant transplantation tolerance impairs CD8+ T cell function but not expansion

2002 • 161 citations

Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients.

1996 • 126 citations

Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells

2004 • 110 citations

Donor-specific transplantation tolerance: The paradoxical behavior of CD4⁺CD25⁺T cells

2004 • 109 citations

The balance of deletion and regulation in allograft tolerance

2003 • 108 citations

Generation of Anergic and Regulatory T Cells following Prolonged Exposure to a Harmless Antigen

2004 • 90 citations

TOLERANCE AND SUPPRESSION IN A PRIMED IMMUNE SYSTEM1

1996 • 87 citations

Heme oxygenase‐1, a protective gene that prevents the rejection of transplanted organs

2001 • 83 citations

PRETRANSPLANT ADMINISTRATION OF A SINGLE DONOR CLASS I MAJOR HISTOCOMPATABILITY COMPLEX MOLECULE IS SUFFICIENT FOR THE INDEFINITE SURVIVAL OF FULLY ALLOGENEIC CARDIAC ALLOGRAFTS

1997 • 82 citations

TGF-β1 Regulates Lymphocyte Homeostasis by Preventing Activation and Subsequent Apoptosis of Peripheral Lymphocytes

2003 • 78 citations

CD28 disruption exacerbates inflammation in Tgf-β1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-β1

2004 • 78 citations

ANTI-CD4 MONOCLONAL ANTIBODY-INDUCED ALLOGRAFT TOLERANCE IN RATS DESPITE PERSISTENCE OF DONOR-REACTIVE T CELLS1

1997 • 74 citations

Transplantation tolerance induced by intranasal administration of HY peptides

2004 • 61 citations

Dominant transplantation tolerance

2003 • 45 citations

Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby

2004 • 44 citations

HY peptides modulate transplantation responses to skin allografts

2002 • 35 citations

Antibody-Induced Transplantation Tolerance: The Role of Dominant Regulation

2003 • 27 citations

TGF-β, T-cell tolerance and anti-CD3 therapy

2003 • 24 citations

Dominant Transplantation Tolerance

2001 • 16 citations