Structure-Based Enhancement of Boronic Acid-Based Inhibitors of AmpC β-Lactamase

A functional classification scheme for beta-lactamases and its correlation with molecular structure

1995 • 2,497 citations

Tuberculosis: Commentary on a Reemergent Killer

1992 • 1,400 citations

The MIDAS display system

1988 • 955 citations

Principles of Medicinal Chemistry

1975 • 718 citations

Kanamycin-resistant vectors that are analogues of plasmids pUC8, pUC9, pEMBL8 and pEMBL9

1986 • 444 citations

Molecular docking using shape descriptors

1992 • 420 citations

Kinship and Diversification of Bacterial Penicillin-Binding Proteins and β-Lactamases

1998 • 399 citations

ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.

1981 • 384 citations

The inhibition of class C β-lactamases by boronic acids

1983 • 154 citations

Crystallographic Structure of a Phosphonate Derivative of the Enterobacter cloacae P99 Cephalosporinase: Mechanistic Interpretation of a .beta.-Lactamase Transition-State Analog

1994 • 145 citations

Serine protease mechanism: structure of an inhibitory complex of .alpha.-lytic protease and a tightly bound peptide boronic acid

1987 • 137 citations

Sequence and comparative analysis of three Enterobacter cloacae ampC β-lactamase genes and their products

1988 • 133 citations

Reversible inhibitors of penicillinases

1978 • 131 citations

Molecular basis of beta-lactamase induction in bacteria

1993 • 113 citations

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines

1985 • 89 citations

Acylamido boronic acids and difluoroborane analogs of amino acids: potent inhibitors of chymotrypsin and elastase

1985 • 87 citations

Crystal Structure of an Acylation Transition-State Analog of the TEM-1 β-Lactamase. Mechanistic Implications for Class A β-Lactamases

1998 • 83 citations

Heterocycles as donor and acceptor units in push-pull conjugated molecules. Part 1

1997 • 80 citations

The Garrod Lecture Evasion of antibiotic action by bacteria

1996 • 72 citations

Inhibition of subtilisin by boronic acids, potential analogs of tetrahedral reaction intermediates

1974 • 69 citations

Antimicrobial resistance: prognosis for public health

1994 • 67 citations

A quick method for the determination of inhibition constants

1982 • 59 citations

Phenyl-n-butylborinic acid is a potent transition state analog inhibitor of lipolytic enzymes

1986 • 41 citations