Antipsychotic drug regulation of AMPA receptor affinity states and GluR1, GluR2 splice variant expression

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

A Family of AMPA-Selective Glutamate Receptors

1990 • 1,453 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

1995 • 1,239 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's disease

1990 • 1,102 citations

A Canadian Multicenter Placebo-Controlled Study of Fixed Doses of Risperidone and Haloperidol in the Treatment of Chronic Schizophrenic Patients

1993 • 884 citations

Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area

1992 • 832 citations

Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

1994 • 735 citations

Early-Onset Epilepsy and Postnatal Lethality Associated with an Editing-Deficient GluR-B Allele in Mice

1995 • 564 citations

Glutamate-operated channels: Developmentally early and mature forms arise by alternative splicing

1991 • 560 citations

Statistical Analysis in Chemistry and the Chemical Industry

1955 • 550 citations

AMPA and kainate receptors

1995 • 460 citations

Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

1988 • 429 citations

The Mechanism of Action of Novel Antipsychotic Drugs

1991 • 410 citations

Mechanisms of action of atypical antipsychotic drugs: a critical analysis

1996 • 315 citations

Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs

1997 • 284 citations

A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques

1991 • 260 citations

Direct somatosensory projections from the spinal cord to the hypothalamus and telencephalon

1987 • 235 citations

Direct Measurement of AMPA Receptor Desensitization Induced by Glutamatergic Synaptic Transmission

1996 • 209 citations

Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

1994 • 203 citations

Classification of neuroleptic drugs according to their ability to inhibit apomorphine-induced locomotion and gnawing: Evidence for two different mechanisms of action

1978 • 198 citations

Differential sparing of somatostatin‐neuropeptide y and cholinergic neurons following striatal excitotoxin lesions

1989 • 197 citations

Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia

1993 • 196 citations

Survey on the pharmacodynamics of the new antipsychotic risperidone

1994 • 195 citations

Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs

1995 • 171 citations

Statistical analysis in chemistry and the chemical industry

1955 • 170 citations

Characterization of typical and atypical antipsychotic drugs based on in vivo occupancy of serotonin2 and dopamine2 receptors.

1993 • 170 citations

A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques

1992 • 128 citations

Chaotropic Ions Affect the Conformation of Quisqualate Receptors in Rat Cortical Membranes

1988 • 123 citations

Therapeutic effect and safety of increasing doses of risperidone (R 64766) in psychotic patients

1989 • 120 citations

Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats

1993 • 118 citations

Autoradiographic Characterization and Localization of Quisqualate Binding Sites in Rat Brain Using the Antagonist [³H]6‐Cyano‐7‐Nitroquinoxaline‐2,3‐Dione: Comparison with (R,S)‐[³H]α‐Amino‐3‐Hydroxy‐5‐Methyl‐4‐Isoxazolepropionic Acid Binding Sites

1990 • 103 citations

Excitatory Amino Acid Receptors in Schizophrenia

1993 • 90 citations

Quantitative autoradiography of the dopamine uptake complex in rat brain using [3H]GBR 12935: binding characteristics

1991 • 80 citations

Characterization of Excitatory Amino Acid Modulation of Dopamine Release in the Prefrontal Cortex of Conscious Rats

1996 • 78 citations

Chronic haloperidol, but not clozapine, produces altered oral movements and increased extracellular glutamate in rats

1994 • 75 citations

An Animal Model for Coexisting Tardive Dyskinesia and Tardive Parkinsonism

1993 • 75 citations

Effects of a centrally active benzoylpiperidine drug on α-amino-3-hydroxy-5-methyl-4-isoxalepropionic acid receptor kinetics

1996 • 72 citations

Excitatory amino acid AMPA receptor mRNA localization in several regions of normal and neurological disease affected human brain. An in situ hybridization histochemistry study

1994 • 70 citations

Thiocyanate stabilizes AMPA binding to the quisqualate receptor

1988 • 65 citations

The NMDA glycine site antagonist (+)-HA-966 selectively regulates conditioned stress-induced metabolic activation of the mesoprefrontal cortical dopamine but not serotonin systems: a behavioral, neuroendocrine, and neurochemical study in the rat

1994 • 64 citations

Evidence For Two Neurochemical Divisions in the Human Nucleus Accumbens

1994 • 64 citations

Developmental changes in α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor properties and expression in the rat hippocampal formation

1995 • 60 citations

Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine.

1996 • 48 citations

Effect of thiocyanate on ampa receptor mediated responses in excised patches and hippocampal slices

1995 • 44 citations

Receptor binding in drug research

1987 • 43 citations

The effect of chronic haloperidol treatment on glutamate receptor subunit (GluR1, GluR2, KA1, KA2, NR1) mRNAs and glutamate binding protein mRNA in rat forebrain

1996 • 43 citations

Thiocyanate equally increases affinity for two DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptor states.

1993 • 34 citations

Chronic antipsychotic treatment alters glycine-stimulated NMDA receptor binding in rat brain

1996 • 33 citations

An isolated rat vibrissal preparation with stable responses of slowly adapting mechanoreceptors

1996 • 32 citations

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors modulate dopamine release in rat hippocampus and striatum

1995 • 30 citations

Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains

1994 • 27 citations

Splice variants of glutamate receptor subunits 2 and 3 in striatal projection neurons

1996 • 25 citations

D2 dopamine receptor messenger RNA is altered to a greater extent by blockade of glutamate receptors than by blockade of dopamine receptors

1994 • 25 citations

Differential changes in glutamate receptor subunit messenger RNAs in rat brain after haloperidol treatment

1994 • 21 citations

Chronic treatment with typical and atypical antipsychotics increases the AMPA-preferring form of AMPA receptor in rat brain

1996 • 17 citations

Regional Decreases in α‐[³H]Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid ([³H]AMPA) and 6‐[³H]Cyano‐7‐Nitroquinoxaline‐2,3‐dione ([³H]CNQX) Binding in Response to Chronic Low‐Level Lead Exposure: Reversal Versus Potentiation by Chronic Dopamine Agonist Treatment

1997 • 12 citations

Phospholipase A₂ Down‐Regulates the Affinity of [³H]AMPA Binding to Rat Cortical Membranes

1995 • 11 citations

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