Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999

1999 • 3,156 citations

Proteins: Structures and Molecular Properties

1986 • 2,694 citations

Principles of protein-protein interactions.

1996 • 2,594 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

1997 • 1,905 citations

Clinical diagnosis and management by laboratory methods

1979 • 1,701 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Proteins. Structures and molecular properties

1984 • 1,247 citations

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1998 • 852 citations

MultiCoil: A program for predicting two‐and three‐stranded coiled coils

1997 • 723 citations

The SWISS-PROT protein sequence data bank and its supplement TrEMBL

1997 • 709 citations

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1997 • 697 citations

Molecular Cloning of Transferrin Receptor 2

1999 • 638 citations

Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor

1998 • 635 citations

Structure of human lactoferrin: Crystallographic structure analysis and refinement at 2·8 Å resolution

1989 • 588 citations

STRUCTURAL BASIS OF T CELL RECOGNITION

1999 • 518 citations

The Hemochromatosis Founder Mutation in HLA-H Disrupts β2-Microglobulin Interaction and Cell Surface Expression

1997 • 481 citations

Iron metabolism

1999 • 408 citations

Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β ₂ -microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

1997 • 388 citations

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

1997 • 342 citations

Clinical Diagnosis and Management by Laboratory Methods

1991 • 333 citations

Crystal Structure of the Ectodomain of Human Transferrin Receptor

1999 • 303 citations

Molecular medicine and hemochromatosis: At the crossroads

1999 • 295 citations

Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract

1997 • 259 citations

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

1999 • 249 citations

Co-trafficking of HFE, a Nonclassical Major Histocompatibility Complex Class I Protein, with the Transferrin Receptor Implies a Role in Intracellular Iron Regulation

1998 • 234 citations

The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells

1999 • 214 citations

A new role for the transferrin receptor in the release of iron from transferrin

1991 • 186 citations

The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor 1 1Edited by I. A. Wilson

1999 • 183 citations

Two Novel Missense Mutations of the HFE Gene (I105T and G93R) and Identification of the S65C Mutation in Alabama Hemochromatosis Probands

1999 • 178 citations

Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH

1991 • 125 citations

Refined Crystal Structure of the Seryl-tRNA Synthetase from Thermus thermophilus at 2·5 Å Resolution

1993 • 100 citations

Physical characterization of the transferrin receptor in human placentae.

1981 • 86 citations

The Transferrin Receptor Binding Site on HFE, the Class I MHC-related Protein Mutated in Hereditary Hemochromatosis

1999 • 84 citations

Iron Is Hot: An Update on the Pathophysiology of Hemochromatosis

1998 • 84 citations

Template Convolution to Enhance or Detect Structural Features in Macromolecular Electron-Density Maps

1997 • 80 citations

Regulation of insulin receptor functions by a peptide derived from a major histocompatibility complex class I antigen

1990 • 73 citations

Iron Is Hot: An Update on the Pathophysiology of Hemochromatosis

1998 • 70 citations

The anion requirement for iron release from transferrin is preserved in the receptor-transferrin complex

1993 • 68 citations

A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin

1999 • 61 citations

Structural model of phospholipid-reconstituted human transferrin receptor derived by electron microscopy

1998 • 58 citations

A pH-dependent reversible conformational transition of the human transferrin receptor leads to self-association.

1988 • 48 citations

Unusual MHC-like molecules; CD1, Fc receptor, the hemochromatosis gene product, and viral homologs

1998 • 43 citations

Specific molecular interaction between the insulin receptor and a D product of MHC class I.

1989 • 40 citations

Functional Analysis of Human/Chicken Transferrin Receptor Chimeras Indicates that the Carboxy‐Terminal Region is Important for Ligand Binding

1996 • 38 citations

Comprehensive molecular modelling system

1986 • 16 citations