Molecular medicine and hemochromatosis: At the crossroads

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

Nonalcoholic steatohepatitis: An expanded clinical entity

1994 • 1,113 citations

Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis

1985 • 1,069 citations

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

1998 • 946 citations

Long-term survival in patients with hereditary hemochromatosis

1996 • 895 citations

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1998 • 852 citations

Global prevalence of putative haemochromatosis mutations.

1997 • 784 citations

Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis

1986 • 670 citations

Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis

1998 • 668 citations

Prevalence of Hemochromatosis among 11,065 Presumably Healthy Blood Donors

1988 • 646 citations

Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor

1998 • 635 citations

HFE gene knockout produces mouse model of hereditary hemochromatosis

1998 • 535 citations

The Hemochromatosis Founder Mutation in HLA-H Disrupts β2-Microglobulin Interaction and Cell Surface Expression

1997 • 481 citations

Mutation Analysis in Hereditary Hemochromatosis

1996 • 429 citations

Nramp2 is mutated in the anemic Belgrade (b) rat : evidence of a role for Nramp2 in endosomal iron transport

1998 • 410 citations

Measurements of iron status in patients with chronic hepatitis

1992 • 399 citations

Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β ₂ -microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

1997 • 388 citations

Idiopathic Hemochromatosis

1977 • 355 citations

Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis

1997 • 342 citations

Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis

1998 • 337 citations

NONALCOHOLIC STEATOHEPATITIS: AN EXPANDED CLINICAL ENTITY

1994 • 329 citations

Increased frequency of the haemochromatosis Cys282Tyr mutation in sporadic porphyria cutanea tarda

1997 • 321 citations

Mutation analysis of the HLA-H gene in Italian hemochromatosis patients.

1997 • 312 citations

Hereditary Hemochromatosis

1979 • 303 citations

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

1998 • 297 citations

Iron Overload in Africa

1992 • 285 citations

Hereditary Hemochromatosis

1998 • 284 citations

Porphyria cutanea tarda, hepatitis C, and HFE gene mutations in north america

1998 • 273 citations

Hemosiderosis in cirrhosis: A study of 447 native livers

1997 • 267 citations

Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C

1995 • 264 citations

Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract

1997 • 259 citations

Regulation of Iron Metabolism in Eukaryotes

1997 • 248 citations

Heterogeneity of hemochromatosis in Italy☆☆☆

1998 • 247 citations

The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis

1997 • 240 citations

Long-term survival analysis in hereditary hemochromatosis

1991 • 236 citations

Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron.

1994 • 231 citations

Response to interferon α therapy is influenced by the iron content of the liver

1994 • 216 citations

Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C

1998 • 207 citations

Surival and prognostic factors in 212 Italian patients with genetic hemochromatosis

1992 • 203 citations

A simple genetic test identifies 90% of UK patients with haemochromatosis

1997 • 203 citations

Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis

1982 • 203 citations

A simple genetic test identifies 90% of UK patients with haemochromatosis

1997 • 200 citations

High prevalence of the His63Asp HFE mutation in italian patients with porphyria cutanea tarda

1998 • 199 citations

Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.

1996 • 197 citations

Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins

1997 • 197 citations

Genotypic/phenotypic correlations in genetic hemochromatosis: Evolution of diagnostic criteria

1998 • 196 citations

Clinical Features of Genetic Hemochromatosis in Women Compared with Men

1997 • 180 citations

Prevalence of haemochromatosis amongst asymptomatic Australians

1990 • 180 citations

Genetic and Clinical Description of Hemochromatosis Probands and Heterozygotes: Evidence That Multiple Genes Linked to the Major Histocompatibility Complex Are Responsible for Hemochromatosis

1997 • 176 citations

Expression of HLA-linked hemochromatosis in subjects homozygous or heterozygous for the C282Y mutation☆☆☆

1998 • 170 citations

Screening blood donors for hereditary hemochromatosis: Decision analysis model based on a 30-year database

1995 • 149 citations

Mutations in the MHC class I-like candidate gene for hemochromatosis in French patients

1997 • 144 citations

Distribution of transferrin saturation in an Australian population: Relevance to the early diagnosis of hemochromatosis

1998 • 142 citations

AN ANALYSIS OF LIVER TRANSPLANT EXPERIENCE FROM 37 TRANSPLANT CENTERS AS REPORTED TO MEDICARE

1993 • 141 citations

The C282Y mutation in the haemochromatosis gene (HFE) and hepatitis C virus infection are independent cofactors for porphyria cutanea tarda in Australian patients

1998 • 129 citations

Outcome of liver transplantation in patients with hemochromatosis

1994 • 120 citations

Hemochromatosis: Genetic or alcohol-induced?

1983 • 105 citations

HFE mutations in patients with hereditary haemochromatosis in Sweden

1998 • 104 citations

Primary liver cancer and survival in patients undergoing liver transplantation for hemochromatosis

1995 • 100 citations

Cost-effectiveness of Screening for Hereditary Hemochromatosis

1994 • 97 citations

Hemochromatosis screening in asymptomatic ambulatory men 30 years of age and older

1995 • 93 citations

Perinatal hemochromatosis. Clinical, morphologic, and quantitative iron studies.

1987 • 92 citations

Screening for hemochromatosis: A cost-effectiveness study based on 12,258 patients

1994 • 91 citations

Juvenile and adult hemochromatosis are distinct genetic disorders.

1998 • 87 citations

Coordinate Post-Transcriptional Regulation of Ferritin and Transferrin Receptor Expression: The Role of Regulated RNA-Protein Interaction

1990 • 86 citations

Primary Iron Overload in African Americans

1996 • 84 citations

Diagnosis and management of hemochromatosis

1997 • 83 citations

Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease

1998 • 82 citations

Translational Repressor Activity Is Equivalent and Is Quantitatively Predicted by in Vitro RNA Binding for Two Iron-responsive Element-binding Proteins, IRP1 and IRP2

1995 • 82 citations

Juvenile and Adult Hemochromatosis Are Distinct Genetic Disorders

1997 • 80 citations

Correlation Between Genotype and Phenotype in Hereditary Hemochromatosis: Analysis of 61 Cases

1997 • 78 citations

Prevalence of hereditary hemochromatosis in a Massachusetts corporation: Is Celtic origin a risk factor?

1997 • 70 citations

Implications of genotyping of spouses to limit investigation of children in genetic hemochromatosis

1998 • 64 citations

Idiopathic neonatal iron storage involving the liver, pancreas, heart, and endocrine and exocrine glands

1981 • 64 citations

Analysis of the cost of population screening for haemochromatosis using biochemical and genetic markers

1997 • 63 citations

Familial iron overload with possible autosomal dominant inheritance

1990 • 60 citations

Rate of Iron Reaccumulation Following Iron Depletion in Hereditary Hemochromatosis Implications for Venesection Therapy

1993 • 55 citations

Mutation analysis of the HFE gene associated with hereditary hemochromatosis in African Americans

1998 • 53 citations

Clinical and family studies in genetic hemochromatosis: Microsatellite and HFE studies in five atypical families

1997 • 50 citations

Beneficial effect of iron reduction therapy in patients with chronic hepatitis C who failed to respond to interferon-$alpha;

1993 • 42 citations

Distribution of Transferrin Saturations in the African-American Population

1998 • 40 citations

Clinical characteristics of hereditary hemochromatosis patients who lack the C282Y mutation

1998 • 39 citations

Evaluation of the hepatic iron index as a diagnostic criterion for genetic hemochromatosis

1997 • 38 citations

Factors affecting the rate of iron mobilization during venesection therapy for genetic hemochromatosis

1998 • 36 citations

Orthotopic liver transplantation for hemochromatosis.

1991 • 27 citations

Cost-effectiveness of screening for hereditary hemochromatosis

1994 • 27 citations

Hereditary hemochromatosis

1997 • 21 citations

Defective iron homeostasis in β2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man

1997 • 20 citations

Relationships among serum iron status markers, chemical and histochemical liver iron content in 117 patients with alcoholic and non-alcoholic hepatic disease.

1994 • 19 citations

Juvenile Hemochromatosis

1988 • 9 citations

Population screening for hemochromatosis with the unbound iron-binding capacity (UIBC)

1998 • 7 citations

Non-alcoholic steatohepatitis (NASH) and hereditary hemochromatosis (HHC)

1998 • 5 citations

The C282Y mutation is not a significant cofactor for more severe liver disease in a cohort of irish hepatitis C patients

1998 • 3 citations

Effect of dietary iron loading in chimpanzees with chronic hepatitis C virus infection

1998 • 2 citations