Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

2003 • 3,707 citations

Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease.

1989 • 2,337 citations

STUDIES ON EXPERIMENTAL HYPERTENSION

1934 • 2,092 citations

Dietary Protein Intake and the Progressive Nature of Kidney Disease:

1982 • 2,066 citations

A Role for Uric Acid in the Progression of Renal Disease

2002 • 1,266 citations

Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism

2001 • 1,261 citations

Glomeruli and Blood Pressure: Less of One, More the Other?

1988 • 1,246 citations

Hyperuricemia induces endothelial dysfunction

2005 • 1,156 citations

Nephron Number in Patients with Primary Hypertension

2003 • 1,073 citations

Arterial pressure regulation

1972 • 1,044 citations

Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism

2002 • 806 citations

Uric Acid Stimulates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells Via Mitogen-Activated Protein Kinase and Cyclooxygenase-2

2003 • 769 citations

Glomerular number and size in autopsy kidneys: The relationship to birth weight

2003 • 741 citations

Molecular Genetics of Human Blood Pressure Variation

1996 • 637 citations

The effect of intrauterine growth retardation on the development of renal nephrons

1992 • 572 citations

Effects of Xanthine Oxidase Inhibition With Allopurinol on Endothelial Function and Peripheral Blood Flow in Hyperuricemic Patients With Chronic Heart Failure

2002 • 559 citations

Uric Acid, Hominoid Evolution, and the Pathogenesis of Salt-Sensitivity

2002 • 548 citations

Hyperuricemia in Childhood Primary Hypertension

2003 • 522 citations

Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia

2003 • 510 citations

Serum Uric Acid and Plasma Norepinephrine Concentrations Predict Subsequent Weight Gain and Blood Pressure Elevation

2003 • 508 citations

Metabolic risk factors for coronary heart disease in women: Perspective from the Framingham Study

1987 • 483 citations

Allopurinol Normalizes Endothelial Dysfunction in Type 2 Diabetics With Mild Hypertension

2000 • 475 citations

Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension

2002 • 446 citations

Reduced Urinary Excretion of Nitric Oxide Metabolites and Increased Plasma Levels of Asymmetric Dimethylarginine in Men with Essential Hypertension

1999 • 437 citations

HYPERURICEMIA AS A RISK FACTOR OF CORONARY HEART DISEASE: THE FRAMINGHAM STUDY

1985 • 406 citations

Remission of Essential Hypertension after Renal Transplantation

1983 • 389 citations

Uric acid stimulates vascular smooth muscle cell proliferation by increasing platelet-derived growth factor A-chain expression

1991 • 384 citations

Primary role of renal homografts in setting chronic blood pressure levels in rats.

1975 • 349 citations

PRECURSORS OF ESSENTIAL HYPERTENSION: PULMONARY FUNCTION, HEART RATE, URIC ACID, SERUM CHOLESTEROL, AND OTHER SERUM CHEMISTRIES

1990 • 333 citations

Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure.

1997 • 331 citations

Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis.

1997 • 297 citations

Mild hyperuricemia induces glomerular hypertension in normal rats

2002 • 292 citations

PLASMA-URATE MEASUREMENTS IN PREDICTING FETAL DEATH IN HYPERTENSIVE PREGNANCY

1976 • 275 citations

Genome-wide mapping of human loci for essential hypertension

2003 • 266 citations

Hyperuricemia Causes Glomerular Hypertrophy in the Rat

2002 • 264 citations

Serum uric acid and hypertension: the Olivetti heart study.

1994 • 262 citations

RENAL OUTCOME 25 YEARS AFTER DONOR NEPHRECTOMY

2001 • 241 citations

Arteriolar Sclerosis in Hypertensive and Non-Hypertensive Individuals.

1937 • 224 citations

Serum uric acid. Its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia

1973 • 207 citations

The fetal origins of adult hypertension

1992 • 186 citations

Histologic studies of kidney biopsy specimens from patients with hypertension.

1958 • 179 citations

Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition

2001 • 170 citations

Human Fetal Kidney Morphometry during Gestation and the Relationship between Weight, Kidney Morphometry and Plasma Active Renin Concentration at Birth

1996 • 159 citations

Endothelial dysfunction in essential hypertension: clinical implications

2002 • 134 citations

HYPERURICEMIA EXACERBATES CHRONIC CYCLOSPORINE NEPHROPATHY1

2001 • 123 citations

Post-cyclosporine-mediated hypertension and nephropathy: amelioration by vascular endothelial growth factor

2001 • 119 citations

Serum Uric Acid

1973 • 118 citations

A meta-analysis of genome-wide linkage scans for hypertension:The National Heart, Lung and BloodInstitute Family Blood Pressure Program

2003 • 113 citations

Nitric Oxide Modulates Vascular Disease in the Remnant Kidney Model

2002 • 112 citations

Uric acid is closely linked to vascular nitric oxide activity

2001 • 112 citations

Precursors of essential hypertension: Body weight, alcohol and salt use, and parental history of hypertension

1988 • 104 citations

Renal Injury and Salt-Sensitive Hypertension After Exposure to Catecholamines

1999 • 99 citations

Renal Cortical Vasoconstriction Contributes to Development of Salt-Sensitive Hypertension after Angiotensin II Exposure

2001 • 93 citations

Serum Urate as a Predictor of Fetal Outcome in Severe Pre‐Eclampsia

1984 • 78 citations

Acute and chronic changes in renal function following unilateral nephrectomy

1991 • 76 citations

Role of 12-Lipoxygenase in the Stimulation of p38 Mitogen-Activated Protein Kinase and Collagen α5(IV) in Experimental Diabetic Nephropathy and in Glucose-Stimulated Podocytes

2003 • 71 citations

Familial aggregation of blood pressure: a population-based family study in eastern Finland

2000 • 70 citations

Circadian Relationship of Serum Uric Acid and Nitric Oxide

2000 • 69 citations

Hypertension and its relation to renal function 10 years after pregnancy complicated by pre-eclampsia and pregnancy induced hypertension.

2000 • 47 citations

A method for distinguishing salt-sensitive from non-salt-sensitive forms of human and experimental hypertension.

1993 • 46 citations

A method for distinguishing salt-sensitive from non-salt-sensitive forms of human and experimental hypertension

1993 • 41 citations

Subclinical Renal Injury Induced by Transient Cyclosporine Exposure is Associated with Salt-Sensitive Hypertension

2001 • 39 citations

Family history as a predictor of blood pressure in a longitudinal study of Australian children

1998 • 34 citations

The placental transfer and concentration difference in maternal and neonatal serum uric acid at parturition: comparison of normal pregnancies and gestosis.

1987 • 25 citations

A Single Pathway for the Development of Essential Hypertension

2003 • 25 citations

Plasma levels of vascular endothelial growth factor (VEGF) and its receptor, flt-1, in haematological cancers: A comparison with breast cancer

2000 • 23 citations

Renovasculopathies of hypertension and the rise of blood pressure with age in blacks and whites.

1996 • 22 citations

Intrarenal Vascular Lesions Associated with Pre-Eclampsia

1978 • 11 citations

The association between salt sensitivity of blood pressure and family history of hypertension.

1992 • 11 citations