Uric acid is closely linked to vascular nitric oxide activity

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

PHYSICAL ACTIVITY ASSESSMENT METHODOLOGY IN THE FIVE-CITY PROJECT1

1985 • 1,713 citations

Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo

1995 • 1,632 citations

Serum Uric Acid and Cardiovascular Mortality

2000 • 1,497 citations

Serum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study

1999 • 1,283 citations

Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?

2000 • 478 citations

SERUM URIC ACID IN RELATION TO AGE AND PHYSIQUE IN HEALTH AND IN CORONARY HEART DISEASE

1951 • 363 citations

Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure

1997 • 341 citations

Influence of Long-term, Low-Dose, Diuretic-Based, Antihypertensive Therapy on Glucose, Lipid, Uric Acid, and Potassium Levels in Older Men and Women With Isolated Systolic Hypertension<subtitle>The Systolic Hypertension in the Elderly Program</subtitle>

1998 • 292 citations

Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Oral <scp>l</scp> -Arginine in Patients With Heart Failure

1996 • 278 citations

Serum urate as an antioxidant for ascorbic acid

1991 • 257 citations

Uric Acid and Coronary Heart Disease Risk: Evidence for a Role of Uric Acid in the Obesity-Insulin Resistance Syndrome

1995 • 224 citations

Serum uric acid. Its relationship to coronary heart disease risk factors and cardiovascular disease, Evans County, Georgia

1973 • 207 citations

Uric acid metabolism and tubular sodium handling. Results from a population-based study

1993 • 205 citations

Serum uric acid and 11.5-year mortality of middle-aged women: Findings of the Chicago heart association detection project in industry

1989 • 195 citations

Long-Term Estrogen Therapy Improves Vascular Function in Male to Female Transsexuals

1997 • 165 citations

Release of platelet constituents by monosodium urate crystals.

1977 • 152 citations

Correlates of uric acid and its association with asymptomatic carotid atherosclerosis: The ARIC study

1996 • 150 citations

Uric Acid Metabolism and Tubular Sodium Handling

1993 • 146 citations

Regulation of Xanthine Oxidase by Nitric Oxide and Peroxynitrite

2000 • 138 citations

Serum Uric Acid

1973 • 118 citations

Nutritional therapy for peripheral arterial disease: a double-blind, placebo-controlled, randomized trial of HeartBar®

2000 • 108 citations

Evaluation of Renal Handling of Uric Acid in Essential Hypertension: Hyperuricemia Related to Decreased Urate Secretion

1991 • 94 citations

Correlations of Serum Uric Acid and Lipid Concentrations in Normal, Gouty, and Atherosclerotic Men

1967 • 81 citations

Regulation of intracellular xanthine oxidase by endothelial-derived nitric oxide

1996 • 78 citations

Serum uric acid and related factors in 500 hospitalized subjects

1996 • 78 citations

Xanthine Oxidase Reaction with Nitric Oxide and Peroxynitrite

1998 • 66 citations

Serum uric acid and coronary heart disease

1983 • 62 citations

Hyperuricemia in coronary, cerebral and peripheral arterial disease: An explanation

1975 • 60 citations

Endothelial dysfunction in hypercholesterolemia is reversed by a nutritional product designed to enhance nitric oxide activity.

2000 • 57 citations

Cardiovascular risk factors and obesity: Are baseline levels of blood pressure, glucose, cholesterol and uric acid elevated prior to weight gain?

1985 • 51 citations

Association between serum uric acid and some cardiovascular risk factors in a Chinese population

1994 • 46 citations

High uric acid: A metabolic marker of coronary heart disease among alcohol abstainers?

1996 • 45 citations

SERUM URIC ACID LEVELS IN WOMEN

1974 • 44 citations

Modulation of the nitric oxide synthase pathway in atherosclerosis

1998 • 29 citations

Uric acid in hypertension and cardiovascular disease.

1999 • 29 citations

ELEVATED SERUM URIC ACID LEVELS DURING TREATMENT WITH ANTIHYPERTENSIVE DRUGS

1979 • 18 citations

Which antihypertensive drug classes have been shown to be beneficial? What are their benefits? A critique of hypertension treatment trials.

2000 • 7 citations