Toward accurate diagnosis of white matter pathology using diffusion tensor imaging

The meaning and use of the area under a receiver operating characteristic (ROC) curve.

1982 • 20,275 citations

Spin Diffusion Measurements: Spin Echoes in the Presence of a Time-Dependent Field Gradient

1965 • 7,940 citations

Principal warps: thin-plate splines and the decomposition of deformations

1989 • 4,800 citations

Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water

2002 • 2,506 citations

Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia

2003 • 1,674 citations

Demyelination increases radial diffusivity in corpus callosum of mouse brain

2005 • 1,593 citations

Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis

2000 • 907 citations

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease

2003 • 569 citations

Neurological disability correlates with spinal cord axonal loss and reducedN-acetyl aspartate in chronic multiple sclerosis patients

2000 • 559 citations

The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury

1995 • 402 citations

Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats

1997 • 371 citations

Elastic Registration of Biological Images Using Vector-Spline Regularization

2005 • 312 citations

Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging

2006 • 282 citations

Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients

2006 • 282 citations

Axon Loss in the Spinal Cord Determines Permanent Neurological Disability in an Animal Model of Multiple Sclerosis

2002 • 276 citations

Axial and Radial Diffusivity in Preterm Infants Who Have Diffuse White Matter Changes on Magnetic Resonance Imaging at Term-Equivalent Age

2006 • 246 citations

Detecting axon damage in spinal cord from a mouse model of multiple sclerosis

2005 • 233 citations

Traumatic Spinal Cord Injury Produced by Controlled Contusion in Mouse

2000 • 201 citations

Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant

2005 • 171 citations

Diffusion Tensor Imaging of Frontal White Matter Microstructure in Early Alzheimer’s Disease: A Preliminary Study

2005 • 159 citations

MRI diffusion coefficients in spinal cord correlate with axon morphometry

2004 • 145 citations

Dual Role for Fas Ligand in the Initiation of and Recovery from Experimental Allergic Encephalomyelitis

1999 • 137 citations

In vivo serial diffusion tensor imaging of experimental spinal cord injury

2006 • 134 citations

Axon loss is responsible for chronic neurological deficit following inflammatory demyelination in the rat

2005 • 112 citations

Registration and warping of magnetic resonance images to histological sections

1999 • 104 citations

Nerve fibres in spinal cord impact injuries

1983 • 102 citations

Apparent diffusion coefficients in spinal cord transplants and surrounding white matter correlate with degree of axonal dieback after injury in rats.

2005 • 67 citations

Chronic alterations in the cellular composition of spinal cord white matter following contusion injury

2004 • 59 citations

Ex vivo MR determined apparent diffusion coefficients correlate with motor recovery mediated by intraspinal transplants of fibroblasts genetically modified to express BDNF

2003 • 58 citations

Axonal degeneration is an early pathological feature in autoimmune‐mediated demyelination in mice

2001 • 50 citations

Reactions of Oligodendrocytes to Spinal Cord Injury: Cell Survival and Myelin Repair

2000 • 48 citations

Three-Dimensional Registration of Magnetic Resonance Image Data to Histological Sections with Model-Based Evaluation

2005 • 40 citations

Improved detectability of experimental allergic encephalomyelitis in excised swine spinal cords by high b-value q-space DWI

2005 • 39 citations

Evaluation of white matter integrity in ex vivo brains of amyloid plaque-bearing APPsw transgenic mice using magnetic resonance diffusion tensor imaging

2006 • 37 citations

A simple, robust hardware device for passive or active respiratory gating in MRI and MRS experiments

2004 • 28 citations

Experimental Spinal Cord Injury: Qualitative and Quantitative Histopathologic Evaluation

1990 • 25 citations

In vivo 4.0-T magnetic resonance investigation of spinal cord inflammation, demyelination, and axonal damage in chronic-progressive experimental allergic encephalomyelitis

2004 • 24 citations

Correcting spatial distortion in histological images

2005 • 20 citations

Pathology‐guided MR analysis of acute and chronic experimental allergic encephalomyelitis spinal cord lesions at 1.5T

2005 • 11 citations