CB receptor antagonists for the treatment of nicotine addiction

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1993 • 4,950 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

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Treating Tobacco Use and Dependence

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A psychomotor stimulant theory of addiction.

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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

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SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

1994 • 1,743 citations

Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system

1998 • 1,549 citations

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1969 • 1,466 citations

Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

1998 • 1,304 citations

Estimates of global mortality attributable to smoking in 2000

2003 • 1,274 citations

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

2003 • 1,123 citations

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs

1996 • 1,083 citations

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ ₁ Opioid Receptor Mechanism

1997 • 1,078 citations

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

1992 • 827 citations

Addictive Drugs and Brain Stimulation Reward

1996 • 777 citations

Role of dopamine in the behavioural actions of nicotine related to addiction

2000 • 677 citations

Modulation of transmitter release via presynaptic cannabinoid receptors

2001 • 670 citations

Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry

1992 • 654 citations

Addiction: definition and implications

1990 • 644 citations

Mortality from smoking worldwide

1996 • 644 citations

The scientific case that nicotine is addictive

1995 • 643 citations

Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors

1997 • 605 citations

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 • 540 citations

Neuronal localization of cannabinoid receptors in the basal ganglia of the rat

1991 • 515 citations

It could be habit forming: drugs of abuse and striatal synaptic plasticity

2003 • 490 citations

Cellular and synaptic mechanisms of nicotine addiction

2002 • 430 citations

Brain monoamine oxidase A inhibition in cigarette smokers

1996 • 427 citations

Levels, Metabolism, and Pharmacological Activity of Anandamide in CB₁ Cannabinoid Receptor Knockout Mice

2000 • 399 citations

SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats

2002 • 397 citations

Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies.

1999 • 353 citations

Molecular Neurobiology of Drug Addiction

2004 • 347 citations

Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys

2000 • 344 citations

Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine

1997 • 344 citations

Persistent Behavior at High Rates Maintained by Intravenous Self-Administration of Nicotine

1981 • 341 citations

Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary alcohol consumption and lack alcohol‐induced dopamine release in the nucleus accumbens

2003 • 330 citations

Behavioural and biochemical evidence for interactions between Δ9‐tetrahydrocannabinol and nicotine

2002 • 304 citations

Selective dopamine antagonists reduce nicotine self-administration

1991 • 279 citations

Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine

2002 • 274 citations

Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse

2001 • 266 citations

Smoking behaviour and compensation: a review of the literature

1999 • 258 citations

Nicotine-Associated Cues Maintain Nicotine-Seeking Behavior in Rats Several Weeks after Nicotine Withdrawal: Reversal by the Cannabinoid (CB1) Receptor Antagonist, Rimonabant (SR141716)

2004 • 255 citations

Nicotine as a modulator of behavior: beyond the inverted U

2003 • 254 citations

Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors

2003 • 245 citations

Lack of CB1 cannabinoid receptors modifies nicotine behavioural responses, but not nicotine abstinence

2002 • 237 citations

Blockade of Nicotine Self-Administration with Nicotinic Antagonists in Rats

1999 • 235 citations

Nicotine self-administration in rats: strain and nicotine pre-exposure effects on acquisition

1997 • 234 citations

REDUCTION OF VOLUNTARY ETHANOL INTAKE IN ETHANOL-PREFERRING sP RATS BY THE CANNABINOID ANTAGONIST SR-141716

1998 • 230 citations

Δ9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors

1997 • 227 citations

Environmental stimuli promote the acquisition of nicotine self-administration in rats

2002 • 224 citations

LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.

1998 • 223 citations

Nicotine serves as an effective reinforcer of intravenous drug-taking behavior in human cigarette smokers

2004 • 183 citations

Current pharmacological treatments for nicotine dependence

2003 • 182 citations

Acquisition of nicotine self-administration in rats: the effects of dose, feeding schedule, and drug contingency

1998 • 172 citations

Rimonabant, a CB1 antagonist, blocks nicotine-conditioned place preferences

2004 • 171 citations

Stimulation ofIn VivoDopamine Transmission in the Bed Nucleus of Stria Terminalis by Reinforcing Drugs

2000 • 170 citations

Nicotine dependence

2001 • 170 citations

Nicotine-induced place preferences following prior nicotine exposure in rats

1994 • 154 citations

Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

2000 • 141 citations

Nicotine-induced conditioned place preference and conditioned place aversion in mice

1995 • 135 citations

Presynaptic Nicotinic Receptors and the Modulation of Transmitter Release

2007 • 126 citations

SSR591813, a Novel Selective and Partial α₄β₂ Nicotinic Receptor Agonist with Potential as an Aid to Smoking Cessation

2003 • 116 citations

SR147778 [5-(4-Bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a New Potent and Selective Antagonist of the CB1 Cannabinoid Receptor: Biochemical and Pharmacological Characterization

2004 • 115 citations

CB1 cannabinoid receptor agonist WIN 55, 212-2 decreases intravenous cocaine self-administration in rats

1999 • 100 citations

The levels of norharman are high enough after smoking to affect monoamineoxidase B in platelets

2002 • 99 citations

Reinforcing effects of nicotine in humans and experimental animals responding under intermittent schedules of IV drug injection

1988 • 88 citations

Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological study

2002 • 88 citations

The Reinforcing Properties of Nicotine are Associated with a Specific Patterning of c‐fos Expression in the Rat Brain

1996 • 79 citations

Dopaminergic and cholinergic involvement in the discriminative stimulus effects of nicotine and cocaine in rats

2003 • 57 citations

Inter-species consistency in the behavioural pharmacology of nicotine dependence

1999 • 44 citations

The Distribution of Neuronal Nicotinic Acetylcholine Receptors

2000 • 22 citations