Biological Implications of <i>Mycobacterium leprae</i> Gene Expression during Infection

Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen

2001 • 11,901 citations

Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

1997 • 5,415 citations

Massive gene decay in the leprosy bacillus

2001 • 1,761 citations

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages

2003 • 1,374 citations

Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

2000 • 1,300 citations

Mycobacterium tuberculosisPathogenesis and Molecular Determinants of Virulence

2003 • 1,065 citations

Role of the Major Antigen of Mycobacterium tuberculosis in Cell Wall Biogenesis

1997 • 704 citations

Deletion of RD1 fromMycobacterium tuberculosisMimics Bacille Calmette‐Guérin Attenuation

2002 • 561 citations

Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3.

1990 • 544 citations

The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis

1992 • 446 citations

Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin

1998 • 413 citations

Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages

1991 • 396 citations

Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells

1993 • 382 citations

Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis

1999 • 362 citations

The temporal expression profile of Mycobacterium tuberculosis infection in mice

2004 • 360 citations

The Stringent Response of Mycobacterium tuberculosis Is Required for Long-Term Survival

2000 • 336 citations

Role of the extracytoplasmic‐function σ Factor σ^H in Mycobacterium tuberculosis global gene expression

2002 • 285 citations

Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG

1988 • 268 citations

The Alternative Sigma Factor SigH Regulates Major Components of Oxidative and Heat Stress Responses inMycobacterium tuberculosis

2001 • 266 citations

Iron Acquisition and Metabolism by Mycobacteria

1999 • 266 citations

SecA2 functions in the secretion of superoxide dismutase A and in the virulence of Mycobacterium tuberculosis

2003 • 264 citations

Reduced immunopathology and mortality despite tissue persistence in aMycobacterium tuberculosismutant lacking alternative σ factor, SigH

2002 • 230 citations

Definition of Mycobacterium tuberculosis culture filtrate proteins by two-dimensional polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and electrospray mass spectrometry

1997 • 222 citations

Expression of katG in Mycobacterium tuberculosis Is Associated with Its Growth and Persistence in Mice and Guinea Pigs

1998 • 196 citations

Disruption of the Genes Encoding Antigen 85A and Antigen 85B of Mycobacterium tuberculosis H37Rv: Effect on Growth in Culture and in Macrophages

2000 • 196 citations

Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis

1995 • 166 citations

Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry

2001 • 160 citations

T lymphocyte subsets in the skin lesions of patients with leprosy

1983 • 145 citations

Viable M. leprae as a research reagent.

2001 • 137 citations

Two Nonredundant SecA Homologues Function in Mycobacteria

2001 • 135 citations

Mapping and Identification of the Major Cell Wall-Associated Components of Mycobacterium leprae

1998 • 121 citations

Cloning and characterization of a bifunctional RelA/SpoT homologue from Mycobacterium tuberculosis

1999 • 107 citations

A Mycobacterium leprae gene encoding a fibronectin binding protein is used for efficient invasion of epithelial cells and Schwann cells

1995 • 106 citations

Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages

1987 • 92 citations

The effect of phenolic glycolipid-1 from Mycobacterium leprae on the antimicrobial activity of human macrophages.

1988 • 91 citations

The decaying genome ofMycobacterium leprae

2001 • 90 citations

Mycobacterium tuberculosismammalian cell entry operon (mce) homologs inMycobacteriumother than tuberculosis (MOTT)

2002 • 63 citations

Induction of monocyte expression of tumor necrosis factor alpha by the 30-kD alpha antigen of Mycobacterium tuberculosis and synergism with fibronectin.

1996 • 60 citations

Comparative genomics of the leprosy and tubercle bacilli

2000 • 55 citations

Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system

1989 • 50 citations

Genetic Studies on Protein Export in Bacteria

1986 • 45 citations

Invasion Activity of aMycobacterium tuberculosisPeptide Presented by theEscherichia coliAIDA Autotransporter

2002 • 45 citations

Defective Activation of Granuloma Macrophages From Mycobacterium leprae-Infected Nude Mice

1988 • 36 citations

Characterization of the dnaG Locus in Mycobacterium smegmatis Reveals Linkage of DNA Replication and Cell Division

1998 • 34 citations

Catabolic Pathways for Glucose, Glycerol and 6-Phosphogluconate in Mycobacterium leprae grown in Armadillo Tissues

1983 • 22 citations

Measurement of ATP Generation and Decay in Mycobacterium leprae in vitro

1985 • 21 citations

Overexpression, purification, and site-directed spin labeling of the Nramp metal transporter from Mycobacterium leprae

2002 • 20 citations

The role of the macrophage in resistance to the leprosy bacillus.

1994 • 15 citations

Catecholates and mixed catecholate hydroxamates as artificial siderophores for mycobacteria.

2003 • 13 citations

Studying microbial genomes with high-density oligonucleotide arrays

2000 • 12 citations

Purification of Mycobacterium leprae RNA for gene expression analysis from leprosy biopsy specimens

2003 • 11 citations