Homology Modeling Using Multiple Molecular Dynamics Simulations and Docking Studies of the Human Androgen Receptor Ligand Binding Domain Bound to Testosterone and Nonsteroidal Ligands

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

1977 • 19,896 citations

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 • 12,826 citations

A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model

1993 • 7,156 citations

How well does a restrained electrostatic potential (RESP) model perform in calculating conformational energies of organic and biological molecules?

2000 • 3,794 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

A Fast Flexible Docking Method using an Incremental Construction Algorithm

1996 • 2,706 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Application of the multimolecule and multiconformational RESP methodology to biopolymers: Charge derivation for DNA, RNA, and proteins

1995 • 995 citations

The MIDAS display system

1988 • 955 citations

A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens

1990 • 948 citations

A structural role for hormone in the thyroid hormone receptor

1995 • 938 citations

Evaluation of the FLEXX incremental construction algorithm for protein-ligand docking

1999 • 871 citations

The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand

2000 • 802 citations

Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains

1998 • 690 citations

Atomic structure of progesterone complexed with its receptor

1998 • 654 citations

Structural Evidence for Ligand Specificity in the Binding Domain of the Human Androgen Receptor

2000 • 587 citations

Locally accessible conformations of proteins: Multiple molecular dynamics simulations of crambin

1998 • 455 citations

Intermolecular NH2-/Carboxyl-terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

1998 • 233 citations

Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships

2000 • 225 citations

Cutoff size does strongly influence molecular dynamics results on solvated polypeptides

1992 • 225 citations

Discovery of Nonsteroidal Androgens

1998 • 222 citations

The FROG PC series: programs for electron-density and model investigations for proteins

1993 • 213 citations

A Point Mutation in the 5' Splice Site of the Dystrophin Gene First Intron Responsible for X-Linked Dilated Cardiomyopathy

1996 • 159 citations

Conic: A fast renderer for spacefilling molecules with shadows

1991 • 139 citations

Androgen receptor gene mutations identified by SSCP in fourteen subjects with androgen insensitivity syndrome

1992 • 137 citations

Specific Recognition of Androgens by Their Nuclear Receptor

2000 • 123 citations

Hormonal Therapy of Male Hypogonadism

1994 • 115 citations

Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 4. Amidines

1988 • 107 citations

Non-steroidal antiandrogens: Synthesis and biological profile of high-affinity ligands for the androgen receptor

1994 • 106 citations

Expression of platelet-derived growth factor receptors in normal and diseased human kidney. An immunohistochemistry and in situ hybridization study.

1994 • 102 citations

Receptor binding and biological activity of steroidal and nonsteroidal antiandrogens

1981 • 89 citations

Functional Analysis of Six Androgen Receptor Mutations Identified in Patients with Partial Androgen Insensitivity Syndrome

1996 • 80 citations

The Intracellular Receptor and Signal Transducers and Activators of Transcription Factor Superfamilies: Novel Targets for Small-Molecule Drug Discovery

1995 • 77 citations

Enantioselective binding of Casodex to the androgen receptor

1996 • 73 citations

Non-steroidal antiandrogens. Design of novel compounds based on an infrared study of the dominant conformation and hydrogen-bonding properties of a series of anilide antiandrogens

1991 • 69 citations

Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.

1994 • 62 citations

Chiral Nonsteroidal Affinity Ligands for the Androgen Receptor. 1. Bicalutamide Analogues Bearing Electrophilic Groups in the B Aromatic Ring

2000 • 62 citations

A Practical Approach to the Detection of Androgen Receptor Gene Mutations and Pedigree Analysis in Families with X-Linked Androgen Insensitivity

1994 • 44 citations

Design, Synthesis, and Pharmacological Characterization of 4-[4,4-Dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a High-Affinity Nonsteroidal Androgen Receptor Ligand

2000 • 41 citations

Towards the mapping of the progesterone and androgen receptors

1987 • 36 citations

Functional characterisation of mutations in the ligand-binding domain of the androgen receptor gene in patients with androgen insensitivity syndrome

1998 • 29 citations

7α-Iodo and 7α-Fluoro Steroids as Androgen Receptor-Mediated Imaging Agents

1999 • 29 citations

Investigation of the binding interactions of progesterone using muteins of the human progesterone receptor ligand binding domain designed on the basis of a three-dimensional protein model

1999 • 21 citations

Library tries to rebuild flooded collection

1997 • 9 citations

... but seeks 'practical' gene therapy deals

1995 • 5 citations

Bid to give legal protection to laboratory mice in US

1998 • 2 citations

190 PCBS, PCDDS AND PCDFS IN HUMAN MILK DOES A SHORT TERM-CHANGE IN MATERNAL DIET INFLUENCE THEIR CONCENTRATION?

1994 • 1 citations