Does estrogen replacement therapy protect against Alzheimer's disease?

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

1996 • 1,640 citations

Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

1989 • 1,630 citations

Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood

1990 • 1,352 citations

The prevalence of dementia: A quantitative integration of the literature

1987 • 1,300 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Prevalence of Alzheimer's Disease in a Community Population of Older Persons

1989 • 1,128 citations

A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease

1997 • 965 citations

A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease

1994 • 953 citations

Estrogen Deficiency and Risk of Alzheimer's Disease in Women

1994 • 843 citations

The US economic and social costs of Alzheimer's disease revisited.

1994 • 600 citations

Estrogen Replacement Therapy in Older Women

1994 • 596 citations

Alzheimer's disease: A study of epidemiological aspects

1984 • 529 citations

Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats

1985 • 526 citations

Estrogen Replacement Therapy and Risk of Alzheimer Disease

1996 • 504 citations

Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats

1994 • 487 citations

Interleukin‐6: A Cytokine for Gerontolgists

1993 • 457 citations

Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons

1992 • 449 citations

A case‐control study of Alzheimer's disease in Australia

1990 • 449 citations

Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.

1992 • 431 citations

Observations in a preliminary open trial of estradiol therapy for senile dementia-alzheimer's type

1986 • 384 citations

Estrogen Replacement Therapy and Cognitive Function in Older Women

1993 • 383 citations

Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.

1994 • 365 citations

Risk factors for clinically diagnosed Alzheimer's disease

1986 • 365 citations

Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons

1994 • 362 citations

Epidemiology of Alzheimer's Disease

1992 • 340 citations

Antioxidant properties of steroids

1993 • 308 citations

Postmenopausal Estrogen Replacement Therapy and the Risk of Alzheimer's Disease: A Population-based Case-Control Study

1994 • 300 citations

Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus.

1992 • 284 citations

Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease

1996 • 250 citations

Evaluation of Estrogen Treatment in Female Patients with Dementia of the Alzheimer Type.

1994 • 248 citations

A case‐control study of Alzheimer's disease

1990 • 242 citations

Estrogen Regulation of Dopamine Release in the Nucleus Accumbens: Genomic‐and Nongenomic‐Mediated Effects

1994 • 234 citations

Chemotherapy without radiation therapy as initial treatment for primary CNS lymphoma in older patients

1996 • 229 citations

In vivo effects by estrone sulfate on the central nervous system-senile dementia (alzheimer's type)

1989 • 224 citations

Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer's type

1993 • 207 citations

Lipoprotein, apolipoprotein, and lipolytic enzyme changes following estrogen administration in postmenopausal women.

1989 • 187 citations

Synaptogenic action of sex steroids in developing and adult neuroendocrine brain

1991 • 179 citations

Long-Term Estrogen Replacement Therapy in Female Patients with Dementia of the Alzheimer Type: 7 Case Reports

1995 • 151 citations

Lack of postmenopausal estrogen replacement therapy and the risk of dementia

1995 • 142 citations

Hormonal status affects the reactivity of the cerebral vasculature

1995 • 134 citations

Central noradrenergic neurones concentrate 3H-oestradiol

1981 • 131 citations

Increased antioxidant enzyme activity in amyloid beta protein-resistant cells

1996 • 128 citations

Comment

1995 • 105 citations

The participation of interleukin-6 in the pathogenesis of alzheimer's disease

1992 • 100 citations

[34] Estrogens as antioxidants

1990 • 97 citations

Estrogen-induced alterations in synaptic morphology in the midbrain central gray

1988 • 81 citations

Effects of Estradiol on the Diurnal Rhythm of Serotonin Activity in Microdissected Brain Areas of Ovariectomized Rats*

1988 • 73 citations

Clinical Genetics and Genetic Counseling in Alzheimer Disease

1991 • 65 citations

ApoE ϵ4 allelic association with Alzheimer's disease

1994 • 59 citations

Estrogen Induces Synaptic Plasticity in Adult Primate Neurons

1993 • 50 citations

Effects of estradiol and dexamethasone on choline acetyltransferase activity in various rat brain regions

1988 • 45 citations

Steroid hormones and neurotrophism: Relationship to nerve injury

1988 • 45 citations

Role of Estrogens in Peripheral and Cerebral Glucose Utilization

1992 • 38 citations

Failure of Nalmefene and Estrogen to Improve Memory in Alzheimer's Disease

1987 • 11 citations

Poster Presentation

1994 • 9 citations

Clinical genetics and genetic counseling in Alzheimer's disease

1992 • 8 citations