Cardiovascular prevention and blood pressure reduction

Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies

2002 • 9,810 citations

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

2000 • 8,612 citations

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

2001 • 7,165 citations

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

1998 • 6,576 citations

Renoprotective Effect of the Angiotensin-Receptor Antagonist Irbesartan in Patients with Nephropathy Due to Type 2 Diabetes

2001 • 5,812 citations

Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial

1998 • 5,793 citations

Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

2002 • 5,558 citations

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 5,471 citations

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

1998 • 4,813 citations

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy

2000 • 3,103 citations

Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack

2001 • 3,093 citations

Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension

1997 • 2,965 citations

2003 European Society of Hypertension???European Society of Cardiology guidelines for the management of arterial hypertension*

2003 • 2,946 citations

2003 European society of hypertension - European Society of Cardiology guidelines for the management of arterial hypertension

2003 • 2,534 citations

The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes

2001 • 2,520 citations

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators.

2000 • 2,085 citations

Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial

1999 • 2,051 citations

Effect of Blood Pressure Lowering and Antihypertensive Drug Class on Progression of Hypertensive Kidney Disease<SUBTITLE>Results From the AASK Trial</SUBTITLE>

2002 • 1,983 citations

Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension)

1991 • 1,911 citations

Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

2002 • 1,592 citations

MORTALITY AND MORBIDITY RESULTS FROM THE EUROPEAN WORKING PARTY ON HIGH BLOOD PRESSURE IN THE ELDERLY TRIAL*1, *2

1985 • 1,482 citations

Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study

1999 • 1,472 citations

MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

1985 • 1,463 citations

Major Cardiovascular Events in Hypertensive Patients Randomized to Doxazosin vs Chlorthalidone: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

2000 • 1,451 citations

Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39

1998 • 1,435 citations

The Study on Cognition and Prognosis in the Elderly (SCOPE)

2003 • 1,423 citations

Medical Research Council trial of treatment of hypertension in older adults: principal results.

1992 • 1,373 citations

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group

1991 • 1,361 citations

Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?

2001 • 1,353 citations

Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party.

1992 • 1,299 citations

Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT)

2000 • 1,224 citations

Single-Drug Therapy for Hypertension in Men -- A Comparison of Six Antihypertensive Agents with Placebo

1993 • 1,210 citations

Effect of Amlodipine on Morbidity and Mortality in Severe Chronic Heart Failure

1996 • 1,182 citations

Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials

2000 • 1,181 citations

The Effect of Nisoldipine as Compared with Enalapril on Cardiovascular Outcomes in Patients with Non-Insulin-Dependent Diabetes and Hypertension

1998 • 1,166 citations

A Comparison of Outcomes with Angiotensin-Converting–Enzyme Inhibitors and Diuretics for Hypertension in the Elderly

2003 • 1,135 citations

Cardiovascular protection and blood pressure reduction: a meta-analysis

2001 • 963 citations

Effects of Calcium-Channel Blockade in Older Patients with Diabetes and Systolic Hypertension

1999 • 945 citations

Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients With Isolated Systolic Hypertension

1996 • 942 citations

Effect of Ramipril vs Amlodipine on Renal Outcomes in Hypertensive Nephrosclerosis<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

2001 • 931 citations

Randomised trial of effects of calcium antagonists compared with diuretics and β-blockers on cardiovascular morbidity and mortality in hypertension: the Nordic Diltiazem (NORDIL) study

2000 • 923 citations

Outcome Results of the Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial (FACET) in Patients With Hypertension and NIDDM

1998 • 856 citations

Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes

2002 • 848 citations

Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group

1993 • 841 citations

Principal Results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) Trial

2003 • 764 citations

Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension

1998 • 726 citations

Effect of blood pressure control on diabetic microvascular complications in patients with hypertension and type 2 diabetes.

2000 • 688 citations

Effect of Amlodipine on the Progression of Atherosclerosis and the Occurrence of Clinical Events

2000 • 671 citations

Treatment of mild hypertension: A five year controlled drug trial

1980 • 660 citations

Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study

2000 • 615 citations

Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease

1994 • 603 citations

Rationale and Design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

1996 • 598 citations

Nephropathy in Patients with Type 2 Diabetes

2002 • 592 citations

Indications for ACE inhibitors in the early treatment of acute myocardial infarction - Systematic overview of individual data from 100,000 patients in randomized trials

1998 • 549 citations

Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg

1970 • 543 citations

The Australian therapeutic trial in mild hypertension.

1984 • 528 citations

Indications for ACE Inhibitors in the Early Treatment of Acute Myocardial Infarction

1998 • 527 citations

Calcium Antagonist Lacidipine Slows Down Progression of Asymptomatic Carotid Atherosclerosis

2002 • 515 citations

Beta-Blockers Versus Diuretics in Hypertensive Men: Main Results from the HAPPHY Trial

1987 • 477 citations

Shanghai trial of nifedipine in the elderly

1996 • 414 citations

Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study

2002 • 403 citations

Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials

2000 • 402 citations

Final outcome results of the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS). A randomized controlled trial

1996 • 395 citations

Primary Prevention of Stroke

1995 • 367 citations

Cardiovascular Risk and Risk Factors in a Randomized Trial of Treatment Based on the Beta-Blocker Oxprenolol: The International Prospective Primary Prevention Study in Hypertension (IPPPSH)

1985 • 348 citations

Optimisation of antihypertensive treatment by crossover rotation of four major classes

1999 • 336 citations

Discussion

1997 • 315 citations

Post-stroke antihypertensive treatment study. A preliminary result

1995 • 311 citations

Isolated systolic hypertension in the elderly

1990 • 302 citations

Risk factors associated with alterations in carotid intima—media thickness in hypertension

1998 • 301 citations

Chinese Trial on Isolated Systolic Hypertension in the Elderly

2000 • 281 citations

Plasma Acid-Base Patterns in Diabetic Ketoacidosis

1982 • 277 citations

Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group

1979 • 273 citations

Long-Term Effects of Cholesterol Lowering and Angiotensin-Converting Enzyme Inhibition on Coronary Atherosclerosis

2000 • 268 citations

Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian Cardiac Outcomes Trial

2001 • 266 citations

HYPOTENSIVE THERAPY IN STROKE SURVIVORS

1970 • 259 citations

The Verapamil in Hypertension and Atherosclerosis Study (VHAS)

1998 • 258 citations

Surgery's Relevance to an Understanding of Basic Biology

1967 • 258 citations

Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive heart failure.

1979 • 246 citations

Alterations in canine myocardial excitability during ischemia.

1977 • 241 citations

Randomized, placebo-controlled trial of the angiotensin-converting enzyme inhibitor, ramipril, in patients with coronary or other occlusive arterial disease

2000 • 236 citations

H35 Baseline characteristics of the life (Losartan intervention for endpoint reduction) in hypertension study

1997 • 186 citations

Hypertension in the Very Elderly Trial (HYVET)

2001 • 173 citations

Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. Systolic Hypertension in the Elderly Program Cooperative Research Group

1996 • 161 citations

Outcomes With Nifedipine GITS or Co-Amilozide in Hypertensive Diabetics and Nondiabetics in Intervention as a Goal in Hypertension (INSIGHT)

2003 • 158 citations

Rationale and design of the International Verapamil SR/Trandolapril Study (INVEST): an Internet-based randomized trial in coronary artery disease patients with hypertension

1998 • 151 citations

Effects of treatment in hypertension results of a controlled study

1966 • 150 citations

Successes and failures of current treatment of heart failure

1998 • 142 citations

Better blood pressure control: how to combine drugs

2003 • 138 citations

Randomized Double-Blind Comparison of a Calcium Antagonist and a Diuretic in Elderly Hypertensives

1999 • 137 citations

Atenolol in Secondary Prevention after Stroke

1995 • 137 citations

The Irbesartan Type II Diabetic Nephropathy Trial: study design and baseline patient characteristics

2000 • 131 citations

Clinical results of the Verapamil in Hypertension and Atherosclerosis Study

1997 • 120 citations

Systolic and pulse blood pressures (but not diastolic blood pressure and serum cholesterol) are associated with alterations in carotid intima–media thickness in the moderately hypercholesterolaemic hypertensive patients of the Plaque Hypertension Lipid Lowering Italian Study

2001 • 118 citations

Design and baseline characteristics of participants in the African American Study of Kidney disease and hypertension (AASK) pilot study

1996 • 110 citations

Clinical trials update: OPTIME‐CHF, PRAISE‐2, ALL‐HAT

2000 • 110 citations

Angiotensin-converting enzyme inhibition as antiatherosclerotic therapy: no answer yet

1999 • 100 citations

Efficacy of Different Drug Classes Used to Initiate Antihypertensive Treatment in Black Subjects

2001 • 96 citations

Protocol for prospective collaborative overviews of major randomized trials of blood-pressure-lowering treatments

1998 • 96 citations

Rationale and Design for the Controlled ONset Verapamil INvestigation of Cardiovascular Endpoints (CONVINCE) Trial

1998 • 94 citations

Blood pressure reduction in elderly: a randomised controlled trial of methyldopa.

1981 • 92 citations

Study on COgnition and Prognosis in the Elderly (SCOPE)

1999 • 91 citations

Prospective study on the treatment of mild hypertension in the aged.

1981 • 89 citations

Effects of the administration of an angiotensin-converting enzyme inhibitor during the acute phase of myocardial infarction in patients with arterial hypertension

1999 • 88 citations

Antihypertensive Treatment With Metoprolol or Hydrochlorothiazide in Patients Aged 60 to 75 Years

1986 • 87 citations

Diltiazem Improves Cardiac Function and Exercise Capacity in Patients With Idiopathic Dilated Cardiomyopathy

1996 • 86 citations

Effect of Two Different Therapeutic Approaches on Total and Cardiovascular Mortality in a Cardiovascular Study in the Elderly (CASTEL).

1994 • 83 citations

Validation of Heart Failure Events in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Participants Assigned to Doxazosin and Chlorthalidone

2002 • 78 citations

Receptor-Operated Calcium-Permeable Channels in Vascular Smooth Muscle

1989 • 78 citations

Similar 9-year mortality risks and reproducibility for the World Health Organization and American Diabetes Association glucose tolerance categories: the Hoorn Study.

2000 • 77 citations

The Hypertension in the Very Elderly Trial (HYVET)

1994 • 70 citations

RANDOMIZED DOUBLE-BLIND COMPARISON OF A CALCIUM CHANNEL BLOCKER AND A DIURETIC IN ELDERLY HYPERTENSIVES : A FINAL RESULT OF THE NATIONAL INTERVENTIONAL COOPERATIVE STUDY IN ELDERLY HYPERTENSION (NICS-EH)

2000 • 69 citations

Update on the Systolic Hypertension in Europe (Syst-Eur) Trial

1999 • 58 citations

POST-STROKE ANTIHYPERTENSIVE TREATMENT STUDY A PRELIMINARY RESULT

1995 • 57 citations

Rationale, design, and baseline characteristics of the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT)

1997 • 57 citations

The ALLHAT Report: A Case of Information and Misinformation

2003 • 52 citations

Outcome beyond blood pressure control?

2003 • 50 citations

Control of Moderately Raised Blood Pressure: REPORT OF A CO-OPERATIVE RANDOMIZED TRIAL

1973 • 46 citations

Baseline characteristics of participants in the appropriate blood pressure control in diabetes trial

1996 • 45 citations

AUSTRALIAN COMPARATIVE OUTCOME TRIAL OF ANGIOTENSIN‐CONVERTING ENZYME INHIBITOR‐ AND DIURETIC‐BASED TREATMENT OF HYPERTENSION IN THE ELDERLY (ANBP2): OBJECTIVES PROTOCOL

1997 • 44 citations

The Non–Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR) Study

2000 • 43 citations

Orthostatic fall in blood pressure in the very elderly hypertensive: results from the Hypertension in the Very Elderly Trial (HYVET) — pilot

1999 • 40 citations

Calcium-channel blockade and cardiovascular prognosis: recent evidence from clinical outcome trials

2002 • 39 citations

Non-AT1-receptor-mediated protective effect of angiotensin against acute ischaemic stroke in the gerbil

2001 • 38 citations

Usefulness of nisoldipine for prevention of restenosis after percutaneous transluminal coronary angioplasty (results of the NICOLE study)

2001 • 33 citations

Weight-modification trials in older adults: what should the outcome measure be?

2002 • 32 citations

Effects of nisoldipine therapy on myocardial perfusion and neuro-hormonal status in patients with severe ischaemic left ventricular dysfunction

1994 • 32 citations

Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group

1974 • 29 citations

Surgery's relevance to an understanding of basic biology. Tissue repair and cellular regeneration

1967 • 29 citations

The Captopril Prevention Project (CAPPP) in Hypertension—Baseline Data and Current Status

1997 • 28 citations

Evaluating the benefits of an antihypertensive agent using trials based on event and organ damage: the Systolic Hypertension in the Elderly Long-term Lacidipine (SHELL) trial and the European Lacidipine Study on Atherosclerosis (ELSA)

1995 • 22 citations

Why is antihypertensive drug therapy needed in elderly patients with systolodiastolic hypertension?

1994 • 19 citations

Determinants of elevated urinary albumin in the 4,937 type 2 diabetic subjects recruited for the DIABHYCAR Study in Western Europe and North Africa.

2000 • 17 citations

The E.L.S.A. trial: protocol of a randomized trial to explore the differential effect of antihypertensive drugs on atherosclerosis in hypertension.

1994 • 14 citations

The E.L.S.A. Trial

1994 • 13 citations

Antihypertensive treatment with metoprolol or hydrochlorothiazide in patients aged 60 to 75 years. Report from a double-blind international multicenter study

1986 • 12 citations

Specific Phosphodiesterase Inhibition and Maximal and Submaximal Exercise Performance in Patients with Congestive Heart Failure

1989 • 8 citations

Characteristics of published, ongoing, and planned outcome trials in hypertension

1999 • 5 citations

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