Histamine antagonists and asthma

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

The Pharmacological Basis for Therapeutics

1981 • 1,896 citations

RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE

1966 • 762 citations

Cimetidine—A Non-Thiourea H₂-Receptor Antagonist

1975 • 449 citations

Nocturnal Asthma and Changes in Circulating Epinephrine, Histamine, and Cortisol

1980 • 430 citations

Changes During 24 Hours in the Lung Function and Histamine Hyperreactivity of the Bronchial Tree in Asthmatic and Bronchitic Patients

1962 • 265 citations

THE ACTION OF HISTAMINE ON THE RESPIRATORY TRACT IN NORMAL AND ASTHMATIC SUBJECTS 1

1946 • 252 citations

The effects of the H1 and H2 antihistamines on "allergic" histamine release and its inhibition by histamine.

1975 • 233 citations

The Mast Cell ‐its Role in Health and Disease

1978 • 228 citations

Histamine shock

1919 • 226 citations

REACTIONS OF ISOLATED HUMAN ASTHMATIC LUNG AND BRONCHIAL TISSUE TO A SPECIFIC ANTIGEN HISTAMINE RELEASE AND MUSCULAR CONTRACTION

1951 • 222 citations

Histamine and interstitial Pulmonary Edema in the Dog

1971 • 144 citations

Das Freiwerden eines histaminähnlichen Stoffes bei der Anaphylaxie des Meerschweinchens

1932 • 140 citations

Bronchodilating activity of an H blocker, chlorpheniramine

1977 • 123 citations

Venous Plasma Histamine in Exercise- and Hyperventilation Induced Asthma in Man

1981 • 119 citations

Plasma histamine changes during provoked bronchospasm in asthmatic patients

1976 • 107 citations

Histamine H1- and H2-receptors in pulmonary and systemic vasculature of the dog

1975 • 92 citations

The relationship of plasma histamine to the activity of bronchial asthma

1977 • 86 citations

Antihistamines in asthma

1989 • 85 citations

Histamine levels in plasma, blood, and urine in severe asthma, and the effect of corticosteroid treatment.

1976 • 84 citations

THE HISTAMINE CONTENT OF THE BLOOD OF GUINEA PIGS AND DOGS DURING ANAPHYLACTIC SHOCK

1939 • 83 citations

Antihistamines in Bronchial Asthma

1949 • 82 citations

Histamine H₂‐receptors in the sheep bronchus and cat trachea: the action of burimamide

1973 • 78 citations

Clinical investigation of agents with prophylactic anti‐allergic effects in bronchial asthma*

1978 • 78 citations

The velocity of blood flow in health and disease as measured by the effect of histamine on the minute vessels

1929 • 78 citations

Bronchial hyperreactivity to histamine and methacholine in asthmatic children after inhalation of SCH 1000 and chlorpheniramine maleate

1978 • 75 citations

Ranitidine (AH 19065): a new potent, selective histamine H2-receptor antagonist [proceedings].

1979 • 73 citations

Comparison of drug-induced responses of rabbit trachea and bronchus

1976 • 72 citations

Further studies on the mechanism of human histamine-induced asthma *1The effect of an aerosolized H1 receptor antagonist (diphenhydramine)

1977 • 65 citations

Effect of an H1 Blocker, Chlorpheniramine, on Inhalation Tests with Histamine and Allergen in Allergic Asthma

1980 • 62 citations

The pharmacology of sheep tracheobronchial muscle: a relaxant effect of histamine on the isolated bronchi

1969 • 60 citations

Bronchodilatation after inhalation of the antihistamine clemastine.

1978 • 59 citations

Inhaled antihistamines--bronchodilatation and effects on histamine- and methacholine-induced bronchoconstriction.

1978 • 59 citations

Measurement of vital capacity in asthmatic subjects receiving histamine and acetyl-beta-methyl choline. A clinical study

1948 • 58 citations

The use of antihistamines in asthma.

1972 • 57 citations

The Role of Histamine Receptors in Asthma

1981 • 57 citations

The effect of histamine antagonists on antigen-induced contractions of sensitized human bronchus in vitro [proceedings].

1977 • 56 citations

Metabolism of chlorpheniramine maleate in man.

1972 • 54 citations

Protection tests on bronchial allergen challenge with disodium cromoglycate and thiazinamium

1970 • 51 citations

The effects of H1 and H2 antihistamines on histamine inhalation challenges in asthmatic patients.

1979 • 50 citations

THE EFFECT OF ANTIHISTAMINE SUBSTANCES AND OTHER DRUGS ON HISTAMINE BRONCHOCONSTRICTION IN ASTHMATIC SUBJECTS 1

1946 • 50 citations

Effect of a histamine H2-receptor antagonist on immunologically induced mediator release in vitro

1974 • 49 citations

H2 receptor mediated inhibition of immediate type hypersensitivity reactions in vivo.

1978 • 48 citations

Effect of inhaled H1 and H2 receptor antagonist in normal and asthmatic subjects.

1980 • 47 citations

Arterial Plasma Histamine after Exercise in Normal Individuals and in Patients with Exercise-Induced Asthma

1981 • 47 citations

Histamine, Basophils and Eosinophils in Severe Asthma

1979 • 46 citations

The effect of drugs in modifying the response of asthmatic subjects to inhalation of pollen extracts as determined by vital capacity measurements.

1947 • 41 citations

Effects of H1‐ and H2‐receptor blocking agents on histamine‐induced bronchoconstriction in non‐asthmatic subjects.

1979 • 40 citations

Antianaphylactic agents. 1. 2-(Acylamino)oxazoles

1979 • 39 citations

The presence of inhibitory histamine H2-receptors in guinea-pig tracheobronchial muscle

1978 • 39 citations

Magnitude and site of airway response to exercise in asthmatics in relation to arterial histamine levels

1980 • 38 citations

The dual mode of action of histamine in the cat isolated tracheal chain

1968 • 38 citations

Comparison of plasma histamine and cyclic nucleotides after antigen and methacholine inhalation in man

1980 • 38 citations

Rôle of histamine in anaphylaxis and allergy

1947 • 37 citations

Spirometric evaluation of benadryl in asthma

1947 • 36 citations

Some chemical aspects of histamine H2-receptor antagonists.

1976 • 36 citations

Ketotifen in adult asthma.

1980 • 35 citations

Atypical (relaxant) response to histamine in cat bronchus

1977 • 34 citations

Histamine H₂‐receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves

1973 • 34 citations

Studies on the nature of the bronchial ß-adrenoreceptors

1971 • 33 citations

Histamine Receptors in Normal Human Bronchi

1980 • 33 citations

The protective effect of ketotifen in bronchial asthma.

1978 • 33 citations

Some Central and Peripheral Effects of Meclastine, a New Antihistaminic Drug, in Man

1971 • 33 citations

Human lung tissue and anaphylaxis: the effects of histamine on the immunologic release of mediators.

1978 • 31 citations

ANTI‐ASTHMATIC PROPERTIES OF A NEW PERORAL DRUG (HC 20–511.)

1977 • 28 citations

Effect of an inhaled antihistamine (clemastine) as a bronchodilator and as a maintenance treatment in asthma.

1979 • 28 citations

BRONCHOCONSTRICTOR AND BRONCHODILATOR ACTIONS OF ANTIHISTAMINE DRUGS

1955 • 27 citations

Role of H1- and H2-receptors in airway reactions to histamine in conscious sheep

1980 • 27 citations

Ketotifen in childhood asthma: a double-blind placebo controlled trial

1979 • 27 citations

Effects of oral H1 and H2 receptor antagonists in asthma.

1979 • 26 citations

The protective effect of a new oral anti-asthma agent (ketotifen, HC 20--511) against experimentally induced bronchospasm (5 different models).

1978 • 26 citations

Clinical experiences with a new antihistaminic drug

1946 • 26 citations

Preliminary evidence for two subclasses of histamine H2-receptors

1979 • 23 citations

Gastric Secretion in Dogs Treated with Histamine Antagonist, Thymoxyethyldiethylamine

1941 • 21 citations

The effect of metiamide in in vitro and in vivo canine models of type I hypersensitivity reactions

1977 • 21 citations

Thephorin: An experimental and clinical evaluation in allergic states

1948 • 21 citations

Histamine relaxes constricted trachea and bronchi of horse

1977 • 19 citations

Chemical determination of histamine in blood in health and disease

1951 • 18 citations

The Distribution of Histamine in the Blood of Healthy and Asthmatic Children

1970 • 18 citations

The Management of Bronchial Asthma

1952 • 18 citations

Comparisons of reactivity of pulmonary vascular and airway smooth muscle of sheep and calf to tryptamine analogues, histamine, and antigen.

1975 • 16 citations

Pharmacologic characterization of the antiallergic activity of SK&F 78729-A.

1978 • 14 citations

Relaxant action of histamine on rabbit trachea: possible existence of third histamine receptor subtype.

1979 • 13 citations

Histamine receptors of airway smooth muscle of ferret and rat.

1978 • 13 citations

A controlled trial of ketotifen in exercise-induced asthma

1980 • 13 citations

Histamine enhances anaphylactic histamine release from bovine lung and leukocytes via histamine H2-receptor.

1978 • 12 citations

A new synthetic anti-histamine substance derived from phenothiazine; phenergan, 3,277 R.P.

1948 • 11 citations

The protective effect of inhaled BRL 10833 on allergen induced bronchospasm

1976 • 9 citations

CARDIOTONIC ACTION OF RING A-MODIFIED CARDENOLIDES, WITH SPECIAL REFERENCE TO CLEAVAGE OF THE RING

1977 • 9 citations

Comparative studies of several antihistaminic drugs

1948 • 6 citations

Antihistamine drugs in asthma and hay fever.

1947 • 5 citations

Effect of histamine H2 receptor agonists and antagonists on pulmonary histamine release and smooth muscle

1980 • 5 citations

The Effect of H1 and H2 Receptor Antagonists on Bronchial Dose—Response Curves to Histamine in Normal Subjects

1978 • 4 citations

Ketotifen in Bronchial Asthma

1980 • 3 citations

Ketotifen in Bronchial Asthma

2015 • 3 citations

Studies on histamine metabolism in bronchial asthma

1979 • 2 citations

An investigation of the possible disadvantages of antihistamines in allergic asthma.

1972 • 2 citations