AKT activation predicts outcome in breast cancer patients treated with tamoxifen

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

Nuclear Receptor Coregulators: Cellular and Molecular Biology*

1999 • 1,783 citations

A Randomized Trial of Exemestane after Two to Three Years of Tamoxifen Therapy in Postmenopausal Women with Primary Breast Cancer

2004 • 1,746 citations

The protein kinase B/Akt signalling pathway in human malignancy

2002 • 1,609 citations

Targeting the PI3K-Akt pathway in human cancer

2003 • 1,262 citations

Mechanisms of Tamoxifen Resistance: Increased Estrogen Receptor-HER2/neu Cross-Talk in ER/HER2-Positive Breast Cancer

2004 • 1,134 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α

2001 • 934 citations

Nuclear Receptor Coregulators: Cellular and Molecular Biology

1999 • 779 citations

Role of the Estrogen Receptor Coactivator AIB1 (SRC-3) and HER-2/neu in Tamoxifen Resistance in Breast Cancer

2003 • 767 citations

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

1987 • 752 citations

Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.

2002 • 578 citations

Activation of the PI3K/Akt pathway and chemotherapeutic resistance

2002 • 576 citations

Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

2003 • 498 citations

Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

2001 • 489 citations

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines

1999 • 470 citations

Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling

2003 • 464 citations

Cross-Talk between Estrogen Receptor and Growth Factor Pathways as a Molecular Target for Overcoming Endocrine Resistance

2004 • 453 citations

AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

2001 • 449 citations

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells

2003 • 439 citations

Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer

2003 • 424 citations

Overexpression of ErbB2 in cancer and ErbB2-targeting strategies

2000 • 409 citations

Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients

2002 • 389 citations

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer

2000 • 385 citations

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

1997 • 377 citations

Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.

2001 • 360 citations

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

2002 • 341 citations

Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate response.

2003 • 304 citations

Physiological functions of protein kinase B/Akt

2004 • 287 citations

Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma

2004 • 256 citations

Inhibition of protein kinase B/Akt

2002 • 241 citations

Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer

2004 • 211 citations

Putting the Rap on Akt

2004 • 207 citations

Gene amplifications associated with the development of hormone-resistant prostate cancer.

2003 • 204 citations

Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma.

2001 • 170 citations

Effect of estradiol on estrogen receptor-α gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway

2003 • 166 citations

Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells.

2001 • 154 citations

Growth factor receptor cross-talk with estrogen receptor as a mechanism for tamoxifen resistance in breast cancer

2003 • 145 citations

The clinical evaluation of HER‐2 status: which test to use?

2003 • 143 citations

Can Molecular Markers Predict When to Implement Treatment with Aromatase Inhibitors in Invasive Breast Cancer?

2005 • 142 citations

Integration of signal transduction inhibitors with endocrine therapy: an approach to overcoming hormone resistance in breast cancer.

2003 • 137 citations

Aromatase inhibitors in the adjuvant setting: bringing the gold to a standard?

2004 • 131 citations

Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1

2004 • 124 citations

Increased Constitutive Activity of PKB/Akt in Tamoxifen Resistant Breast Cancer MCF-7 Cells

2004 • 124 citations

Overview of treatment results with trastuzumab (Herceptin) in metastatic breast cancer

2001 • 111 citations

Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER‐negative, but not ER‐positive, breast cancer

2004 • 90 citations

Tamoxifen—What Next?

2004 • 66 citations

Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis

2003 • 57 citations

Breast cancer prevention—clinical trials strategies involving aromatase inhibitors

2003 • 54 citations

A perspective on surrogate endpoints in controlled clinical trials

2004 • 54 citations

A role for BRCA1 in sporadic breast cancer

2003 • 50 citations

Modulation of estrogen receptor activity by selective coregulators

2003 • 44 citations

Update of the worldwide evidence on the adjuvant treatment of breast cancer

2002 • 5 citations

Growth inhibition of gastric cancer cell lines by the tyrphostin RG13022 and its effects on intracellular signalling

1996 • 1 citations