The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1997 • 1,332 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

RING Finger Proteins

2000 • 1,216 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

2000 • 1,026 citations

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

1987 • 1,004 citations

cdc25+ functions as an inducer in the mitotic control of fission yeast

1986 • 973 citations

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

1991 • 870 citations

Structure of a c-Cbl–UbcH7 Complex

2000 • 824 citations

Mitosis in transition

1994 • 745 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

1995 • 658 citations

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

2001 • 644 citations

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

2000 • 634 citations

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

1998 • 590 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

1998 • 484 citations

ROC1, a Homolog of APC11, Represents a Family of Cullin Partners with an Associated Ubiquitin Ligase Activity

1999 • 457 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34

1999 • 406 citations

polo encodes a protein kinase homolog required for mitosis in Drosophila.

1991 • 403 citations

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

2000 • 366 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

1991 • 344 citations

The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

2000 • 336 citations

Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7

1999 • 328 citations

The Inhibitor of Apoptosis, cIAP2, Functions as a Ubiquitin-Protein Ligase and Promotes in VitroMonoubiquitination of Caspases 3 and 7

2000 • 294 citations

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

1992 • 294 citations

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.

1993 • 291 citations

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

1988 • 285 citations

SUMO-1 Modification of Mdm2 Prevents Its Self-Ubiquitination and Increases Mdm2 Ability to Ubiquitinate p53

2000 • 271 citations

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans

1991 • 243 citations

Src-catalyzed Phosphorylation of c-Cbl Leads to the Interdependent Ubiquitination of Both Proteins

2001 • 212 citations

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex

2000 • 185 citations

Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

1990 • 184 citations

The APC11 RING-H2 Finger Mediates E2-Dependent Ubiquitination

2000 • 171 citations

Proteolysis and the G1-S transition: the SCF connection

1998 • 156 citations

Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14.

1994 • 129 citations

SCF ubiquitin protein ligases and phosphorylation–dependent proteolysis

1999 • 128 citations

Control of mitotic transitions by the anaphase–promoting complex

1999 • 85 citations

Cell Cycle Tyrosine Phosphorylation of p34^cdc2 and a Microtubule- Associated Protein Kinase Homolog in Xenopus Oocytes and Eggs

1991 • 79 citations

Cell cycle arrest by Colcemid differs in human normal and tumor cells.

1994 • 29 citations