What Have We Learned from Gene Targeting Studies for the Renin Angiotensin System of the Kidney?

Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.

1994 • 1,063 citations

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

1995 • 858 citations

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice

1995 • 740 citations

Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat

1991 • 729 citations

Angiotensin II type 2 receptor mediates programmed cell death.

1996 • 707 citations

The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.

1995 • 688 citations

Male–female differences in fertility and blood pressure in ACE-deficient mice

1995 • 644 citations

Genetic control of blood pressure and the angiotensinogen locus.

1995 • 627 citations

Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

1991 • 614 citations

Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.

1997 • 603 citations

Regulation of blood pressure by the type 1A angiotensin II receptor gene.

1995 • 599 citations

Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.

1995 • 539 citations

Conditional gene targeting.

1996 • 462 citations

Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction.

1995 • 441 citations

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

1996 • 438 citations

Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat.

1976 • 414 citations

Angiotensinogen-deficient mice with hypotension.

1994 • 378 citations

Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney

1977 • 368 citations

Angiotensin II Type 1a Receptor-deficient Mice with Hypotension and Hyperreninemia

1995 • 368 citations

Role of the Angiotensin Type 2 Receptor Gene in Congenital Anomalies of the Kidney and Urinary Tract, CAKUT, of Mice and Men

1999 • 360 citations

Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation.

1995 • 340 citations

Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules.

1984 • 338 citations

Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.

1998 • 338 citations

Angiotensin-converting enzyme inhibitor fetopathy.

1993 • 327 citations

Control of glomerular filtration rate by renin-angiotensin system

1977 • 312 citations

Risks of angiotensin-converting enzyme inhibition during pregnancy: Experimental and clinical evidence, potential mechanisms, and recommendations for use

1994 • 311 citations

Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels

1983 • 281 citations

The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.

1997 • 276 citations

Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension

1992 • 267 citations

Angiotensin II regulates nephrogenesis and renal vascular development

1995 • 265 citations

Early expression of all the components of the renin-angiotensin-system in human development.

1996 • 225 citations

Role of angiotensin subtype 2 receptor in neointima formation after vascular injury.

1992 • 221 citations

Renin-angiotensin system in neonatal rats: Induction of a renal abnormality in response to ACE inhibition or angiotensin II antagonism

1994 • 215 citations

Tissue-specific expression of type 1 angiotensin II receptor subtypes. An in situ hybridization study.

1994 • 182 citations

Expression of angiotensin II AT2 receptors in the rat skin during experimental wound healing

1992 • 171 citations

Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction Rapid Communication

1998 • 170 citations

Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation

1997 • 166 citations

Developmental expression of renal angiotensin II receptor genes in the mouse

1995 • 159 citations

Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.

1997 • 155 citations

Angiotensin induces the urinary peristaltic machinery during the perinatal period.

1998 • 146 citations

Frequency of a Deletion Polymorphism in the Gene for Angiotensin Converting Enzyme Is Increased in African-Americans With Hypertension

1994 • 142 citations

Fibrosis, a common pathway to organ failure: angiotensin II and tissue repair.

1997 • 141 citations

Renal pelvic pacemaker control of ureteral peristaltic rate

1974 • 135 citations

Ontogeny of type 1 angiotensin II receptor gene expression in the rat.

1993 • 135 citations

Effect of angiotensin II and norepinephrine on isolated rat afferent and efferent arterioles

1990 • 126 citations

Angiotensin II stimulates human fetal mesangial cell proliferation and fibronectin biosynthesis by binding to AT1 receptors

1994 • 123 citations

Angiotensin II in renal fibrosis: should TGF-beta rather than blood pressure be the therapeutic target?

1997 • 122 citations

Dual effects of angiotensin II on the plasminogen/plasmin system in rat mesangial cells

1997 • 115 citations

Characterization of angiotensin II receptor type 2 during differentiation and apoptosis of rat ovarian cultured granulosa cells

1995 • 113 citations

Hypotensive Effect of Losartan, a Nonpeptide Angiotensin II Receptor Antagonist, in Essential Hypertension

1993 • 109 citations

Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells.

1996 • 101 citations

Importance of angiogenic action of angiotensin II in the glomerular growth of maturing kidneys

1990 • 99 citations

Nephrogenesis and renovascular development in angiotensinogen-deficient mice.

1996 • 97 citations

Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human)

1992 • 95 citations

Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption

1998 • 84 citations

Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice

1998 • 78 citations

Role of the renin-angiotensin system in tubuloglomerular feedback.

1986 • 50 citations

Genetic control of blood pressure and the angiotensinogen locus.

1995 • 47 citations

Angiotensin on Vascular Smooth Muscle

1974 • 46 citations

The glomerulus of a stenohaline fresh-water teleost, Carassius auratus gibelio, adapted to saline water

1981 • 41 citations

Urodynamics of the upper urinary tract.

1976 • 40 citations

Renal function in the foetal and new‐born guinea‐pig

1958 • 32 citations

A novel in vivo mechanism for angiotensin type 1 receptor regulation

1997 • 18 citations

Characterization of Angiotensin II Receptor Type 2 during Differentiation and Apoptosis of Rat Ovarian Cultured Granulosa Cells

1995 • 6 citations

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