The role of cellular oncogenes in myogenesis and muscle cell hypertrophy

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD

1989 • 1,286 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts.

1989 • 919 citations

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

1989 • 863 citations

MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

1988 • 839 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

1984 • 785 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1

1987 • 696 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Growth factor-like action of phosphatidic acid

1986 • 531 citations

Viral and cellular fos proteins: A comparative analysis

1984 • 523 citations

Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos

1987 • 523 citations

Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.

1990 • 508 citations

Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite

1983 • 500 citations

Positive autoregulation of the myogenic determination gene MyoD1

1989 • 492 citations

Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis

1978 • 491 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

Bimodal Distribution of Dopamine Receptor Densities in Brains of Schizophrenics

1984 • 347 citations

Induction of c-fos during myelomonocytic differentiation and macrophage proliferation

1985 • 340 citations

Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

1986 • 329 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

pp60c-src is developmentally regulated in the neural retina

1984 • 299 citations

Nuclear Localization and DNA Binding Properties of a Protein Expressed by Human c- myc Oncogene

1984 • 288 citations

Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1

1989 • 286 citations

Participation of c- myc Protein in DNA Synthesis of Human Cells

1986 • 282 citations

Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry

1979 • 276 citations

Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle.

1985 • 271 citations

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.

1986 • 263 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

Involvement of common and cell type-specific pathways in c-fos gene control: Stable induction by cAMP in macrophages

1987 • 223 citations

Expression of cellular oncogenes in the myocardium during the developmental stage and pressure-overloaded hypertrophy of the rat heart.

1988 • 222 citations

The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation.

1987 • 221 citations

The Fos Protein Complex Is Associated with DNA in Isolated Nuclei and Binds to DNA Cellulose

1986 • 206 citations

Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation.

1986 • 196 citations

Transformation of chondroblasts by rous sarcoma virus and synthesis of the sulfated proteoglycan matrix

1977 • 190 citations

Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter

1990 • 189 citations

The ski oncogene induces muscle differentiation in quail embryo cells

1989 • 188 citations

Effect of oncogenic virus on muscle differentiation.

1975 • 182 citations

The c-myc proto-oncogene regulates cardiac development in transgenic mice.

1990 • 181 citations

Role of myogenin in myoblast differentiation and its regulation by fibroblast growth factor.

1990 • 177 citations

ski can cause selective growth of skeletal muscle in transgenic mice.

1990 • 174 citations

Analysis of the differentiation-promoting potential of inducible c-fos genes introduced into embryonal carcinoma cells.

1985 • 173 citations

Unique sequence, ski, in Sloan-Kettering avian retroviruses with properties of a new cell-derived oncogene

1986 • 173 citations

Activation of the transforming potential of p60c-src by a single amino acid change.

1986 • 161 citations

Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

1984 • 161 citations

Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype.

1986 • 157 citations

Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4.

1990 • 157 citations

The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription.

1989 • 135 citations

c-myc and c-fos expression in differentiating mouse primary keratinocytes.

1986 • 130 citations

Mitogens and Oncogenes Can Block the Induction of Specific Voltage-Gated Ion Channels

1987 • 114 citations

Transfection of mouse erythroleukemia cells with myc sequences changes the rate of induced commitment to differentiate.

1986 • 112 citations

Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the MyoD1 gene.

1989 • 110 citations

The oncogene jun and nuclear signalling

1989 • 107 citations

Xenopus myc proto-oncogene during development: expression as a stable maternal mRNA uncoupled from cell division.

1986 • 104 citations

Viral transformation of rat myoblasts: Effects on fusion and surface properties

1976 • 100 citations

Proto-oncogene c-myc is expressed in cerebellar neurons at different developmental stages.

1986 • 96 citations

A hemodynamic load in vivo induces cardiac expression of the cellular oncogene, c-myc

1987 • 94 citations

Alterations in pp60^c-src Accompany Differentiation of Neurons from Rat Embryo Striatum

1987 • 90 citations

Autonomous expression of c-myc in BC3H1 cells partially inhibits but does not prevent myogenic differentiation.

1987 • 86 citations

Control of myogenic differentiation by cellular oncogenes

1988 • 69 citations

An activated c-Ha-ras allele blocks the induction of muscle-specific genes whose expression is contingent on mitogen withdrawal.

1987 • 68 citations

Density‐dependent arrest of DNA replication is accompanied by decreased levels of c‐myc mRNA in myogenic but not in differentiation‐defective myoblasts

1985 • 65 citations

Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle

1987 • 62 citations

Requirement of protein co-factor for the DNA-binding function of the human ski proto-oncogene product

1990 • 61 citations

C-myc expression is dissociated from DNA synthesis and cell division in Xenopus oocyte and early embryonic development.

1986 • 61 citations

Characterization of chicken c-ski oncogene products expressed by retrovirus vectors.

1990 • 60 citations

Interaction with normal cells suppresses the transformed phenotype of v-myc-transformed quail muscle cells

1989 • 56 citations

Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum.

1987 • 56 citations

Interaction of Retroviral Oncogenes With The Differentiation Program of Myogenic Cells

1987 • 52 citations

Expression of c-myc and c-fos in rat skeletal muscle. Evidence for increased levels of c-myc mRNA during hypertrophy

1992 • 50 citations

Isolation and characterization of three distinct cDNAs for the chicken c-ski gene.

1989 • 50 citations

Insulin-Like Growth Factor I Induces c-fos Messenger Ribonucleic Acid in L6 Rat Skeletal Muscle Cells*

1987 • 49 citations

Inhibition of myogenic differentiation by fibroblast growth factor or type β transforming growth factor does not require persistent c-myc expression

1987 • 42 citations

Polyproteins containing a domain encoded by the V-SKI oncogene are located in the nuclei of SKV-transformed cells

1986 • 36 citations

Viral transformation of chick myogenic cells

1979 • 35 citations

Role of cell division in differentiation of myoblasts infected with a temperature-sensitive mutant of Rous sarcoma virus.

1984 • 33 citations

Morphological and biochemical differentiation in RSV transformed chick embryo myoblasts

1978 • 32 citations

A new muscle phenotype is expressed by subcultured quail myoblasts isolated from future fast and slow muscles.

1983 • 31 citations

Elevated c‐fos expression inhibits differentiation of L6 rat myoblasts

1989 • 31 citations

Possible role of c-fos, c-N-ras and c-mos proto-oncogenes in muscular development

1987 • 25 citations

High expression levels of ras p21 protein in normal mouse heart tissues

1985 • 25 citations

The ski oncogene.

1991 • 23 citations

Differential expression of protooncogenes related to transformation and cancer progression in rat myoblasts.

1986 • 22 citations

Selective effect of Rous sarcoma virus src gene expression on contractile protein synthesis in chick embryo myotubes.

1983 • 21 citations

Regulation of the expression of proto-oncogene c-src by alternative RNA splicing in chicken skeletal muscle.

1987 • 21 citations

An alternative non-tyrosine protein kinase product of the c-src gene in chicken skeletal muscle.

1990 • 16 citations

Expression of c-src and c-abl in embryonal carcinoma cells and adult mouse tissues

1988 • 15 citations

Proto-oncogenes in cell development (Ciba Foundation Symposium 150)

1991 • 12 citations

Adrenergic regulation of c- expression in cultured BC3H1 muscle cells

1989 • 10 citations

Differential Control of Muscle‐Specific Gene Expression Specified by src and myc Oncogenes in Myogenic Cells

2007 • 6 citations

The ras Pathway: A Model for the Control of Proliferation in Animal Cells

1988 • 5 citations

Detection of c-myc and c-fos mRNA in rat skeletal muscle

1990 • 1 citations