Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line, MCF-7/TAMR-1 compared to the parental MCF-7 cell line

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Current protocols in molecular biology

1988 • 7,584 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Functional domains of the human estrogen receptor

1987 • 1,316 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

Point mutations in the Human Vitamin D Receptor Gene Associated with Hypocalcemic Rickets

1988 • 490 citations

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.

1994 • 481 citations

Genomic organization of the human oestrogen receptor gene.

1988 • 480 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

Variant human breast tumor estrogen receptor with constitutive transcriptional activity.

1991 • 397 citations

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.

1992 • 314 citations

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions

1994 • 293 citations

Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors.

1992 • 251 citations

Identification of a Dominant Negative Form of the Human Estrogen Receptor

1991 • 211 citations

Measurement of steroid hormone receptors in breast cancer patients on tamoxifen

1993 • 195 citations

Estrogen receptor mutations in tamoxifen-resistant breast cancer.

1994 • 192 citations

Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes

1990 • 189 citations

Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7/TAMR-1.

1994 • 162 citations

The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain

1994 • 152 citations

Production of monoclonal antibodies to human estrogen‐receptor protein (ER) using recombinant ER (RER)

1993 • 147 citations

Estrogen receptor expression in human breast cancer associated with an estrogen receptor gene restriction fragment length polymorphism.

1989 • 145 citations

Cell culture for biochemists

1991 • 138 citations

Primary structure of human ribosomal protein S14 and the gene that encodes it.

1986 • 138 citations

Expression of a constitutively active estrogen receptor variant in the estrogen receptor-negative BT-20 human breast cancer cell line.

1993 • 130 citations

Molecular mechanisms of antiestrogen action in breast cancer

1994 • 130 citations

Defining a minimal estrogen receptor DNA binding domain

1993 • 124 citations

T47DCO cells, genetically unstable and containing estrogen receptor mutations, are a model for the progression of breast cancers to hormone resistance.

1990 • 121 citations

Estrogen receptor mutations in breast cancer

1993 • 119 citations

Powerful dominant negative mutants of the human estrogen receptor

1993 • 119 citations

A Variant Estrogen Receptor Messenger Ribonucleic Acid is Associated with Reduced Levels of Estrogen Binding in Human Mammary Tumors

1988 • 108 citations

Truncated forms of DNA-binding estrogen receptors in human breast cancer.

1991 • 104 citations

Quantitative expression patterns of multidrug‐resistance P‐glycoprotein (MDR1) and differentially spliced cystic‐fibrosis transmembrane‐conductance regulator mRNA transcripts in human epithelia

1992 • 97 citations

Estrogen receptor variant messenger RNA lacking exon 4 in estrogen-responsive human breast cancer cell lines.

1993 • 93 citations

Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell lines

1986 • 89 citations

A 22-amino-acid peptide restores DNA-binding activity to dimerization-defective mutants of the estrogen receptor.

1990 • 89 citations

Cell Culture for Biochemists

1980 • 79 citations

A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast

1994 • 72 citations

Genomic DNA analysis of the estrogen receptor gene in breast cancer

1989 • 69 citations

Wild type and alternatively spliced estrogen receptor messenger RNA in human meningioma tissue and MCF7 breast cancer cells

1993 • 61 citations

Functional analysis of an alternatively spliced estrogen receptor lacking exon 4 isolated from MCF-7 breast cancer cells and meningioma tissue

1994 • 61 citations

Exon skipping gives rise to alternatively spliced forms of the estrogen receptor in breast tumor cells

1993 • 58 citations

Altered Gene Expression of c-myc, Epidermal Growth Factor Receptor, Transforming Growth Factor-α, and c-erb-B2 in an Immortalized Human Breast Epithelial Cell Line, HMT-3522, Is Associated with Decreased Growth Factor Requirements

1992 • 54 citations

Characterization of estrogen receptor variant mRNAs from human breast cancers

1992 • 49 citations

Effect of Estrogen and Antiestrogens on Cell Proliferation and Synthesis of Secreted Proteins in the Human Breast Cancer Cell Line MCF-7 and a Tamoxifen Resistant Variant Subline, AL-1

1992 • 48 citations

Characterization of the estrogen receptor in two antiestrogen-resistant cell lines, LY2 and T47D.

1990 • 46 citations

Expression of estrogen receptor variants

1993 • 42 citations

The ER-positive / PgR-negative breast cancer phenotype is not associated with mutations within the DNA binding domain

1993 • 38 citations

Estrogen receptor gene amplification is found in some estrogen receptor-positive human breast tumors

1990 • 36 citations

Point mutation of estrogen receptor (ER) in the ligand-binding domain changes the pharmacology of antiestrogens in ER-negative breast cancer cells stably expressing complementary DNAs for ER

1992 • 32 citations

Endocrine Therapy of Breast Cancer

1989 • 11 citations

Antiestrogens Activate an Estrogen Receptor Mutant Exhibiting Enhanced Binding to the Estrogen Response Element

1994 • 7 citations