The granin protein family: Markers for neuroendocrine cells and tools for the diagnosis of neuroendocrine tumors

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

An Immunohistochemical Study

1989 • 1,928 citations

Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion

1986 • 686 citations

The chromogranins A and B: The first 25 years and future perspectives

1992 • 653 citations

Secretion of Chromogranin A by Peptide-Producing Endocrine Neoplasms

1986 • 480 citations

The granin-(chromogranin/secretogranin) family

1991 • 475 citations

Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network.

1991 • 457 citations

Detection of chromogranin in neuroendocrine cells with a monoclonal antibody.

1984 • 404 citations

Secretogranins I and II: two tyrosine-sulfated secretory proteins common to a variety of cells secreting peptides by the regulated pathway.

1985 • 384 citations

Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases

1992 • 348 citations

Specific Endocrine Tissue Marker Defined by a Monoclonal Antibody

1983 • 341 citations

Synaptophysin and chromogranins/secretogranins widespread constituents of distinct types of neuroendocrine vesicles and new tools in tumor diagnosis

1989 • 326 citations

The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation

1989 • 309 citations

Chromogranin A, B and C immunoreactivities of mammalian endocrine cells

1986 • 290 citations

Cell-free protein sorting to the regulated and constitutive secretory pathways

1990 • 289 citations

The primary structure of human chromogranin A and pancreastatin.

1987 • 286 citations

Secretoneurin—a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II (chromogranin C)

1993 • 264 citations

The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region.

1987 • 229 citations

Radioimmunoassay of Chromogranin a in Plasma as a Measure of Exocytotic Sympathoadrenal Activity in Normal Subjects and Patients with Pheochromocytoma

1984 • 228 citations

Is chromogranin a prohormone?

1987 • 223 citations

THE SEQUENCE OF PORCINE CHROMOGRANIN A MESSENGER RNA DEMONSTRATES CHROMOGRANIN A CAN SERVE AS THE PRECURSOR FOR THE BIOLOGICALLY ACTIVE HORMONE, PANCREASTATIN

1988 • 199 citations

Chromogranin immunoreactivity in the central nervous system. Immunochemical characterisation, distribution and relationship to catecholamine and enkephalin pathways

1984 • 193 citations

Neuroendocrine Differentiation in Endocrine and Nonendocrine Lung Carcinomas

1988 • 191 citations

Prognostic factors in medullary thyroid carcinomas.Survival in relation to age, sex, stage, histology, immunocytochemistry, and DNA content

1988 • 188 citations

IMMUNOREACTIVE HUMAN CHROMOGRANIN A IN DIVERSE POLYPEPTIDE HORMONE PRODUCING HUMAN TUMORS AND NORMAL ENDOCRINE TISSUES

1983 • 186 citations

Primary Ovarian Small Cell Carcinoma of Pulmonary Type

1992 • 178 citations

Immunohistochemical detection of chromogranin and neuron-specific enolase in pancreatic endocrine neoplasms

1984 • 172 citations

Rapid radioimmunoassay of circulating chromogranin A: in vitro stability, exploration of the neuroendocrine character of neoplasia, and assessment of the effects of organ failure.

1989 • 168 citations

Chromogranin: A newly recognized marker for endocrine cells of the human gastrointestinal tract

1985 • 168 citations

Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-Golgi network causes its missorting to the constitutive secretory pathways.

1993 • 156 citations

Small-Cell Undifferentiated Carcinoma of the Cervix

1988 • 150 citations

Duodenal Carcinoids in Patients with and without Neurofibromatosis

1986 • 149 citations

Immunoreactive neuron-specific enolase, bombesin, and chromogranin as markers for neuroendocrine lung tumors

1985 • 149 citations

Rectal and colonic carcinoids. A clinicopathologic study of 84 cases

1990 • 148 citations

Secretoneurin releases dopamine from rat striatal slices: A biological effect of a peptide derived from secretogranin II (chromogranin C)

1993 • 145 citations

Chromostatin, a 20-amino acid peptide derived from chromogranin A, inhibits chromaffin cell secretion.

1991 • 140 citations

Carcinoid tumors of the thymus

1990 • 135 citations

Chromogranin A, B, and C in human adrenal medulla and endocrine tissues.

1986 • 132 citations

Small cell carcinoma of the major salivary glands

1986 • 131 citations

Distribution of chromogranin A and secretogranin I (chromogranin B) in neuroendocrine cells and tumors.

1988 • 130 citations

Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily

1983 • 129 citations

A nomenclature proposal for the chromogranin/secretogranin proteins

1987 • 126 citations

Distribution of chromogranin and S100 protein in normal and abnormal adrenal medullary tissues.

1985 • 123 citations

Immunohistochemical localization of epinephrine, norepinephrine, catecholamine-synthesizing enzymes, and chromogranin in neuroendocrine cells and tumors.

1986 • 122 citations

Ultrastructural localization of chromogranin: a potential marker for the electron microscopical recognition of endocrine cell secretory granules

1985 • 120 citations

Parastatin (porcine chromogranin A347-419), a novel chromogranin A-derived peptide, inhibits parathyroid cell secretion.

1993 • 119 citations

Sorting of three secretory proteins to distinct secretory granules in acidophilic cells of cow anterior pituitary.

1987 • 117 citations

An antibody against secretogranin I (chromogranin B) is packaged into secretory granules.

1989 • 116 citations

Chromogranin A in the pancreatic islet: cellular and subcellular distribution.

1986 • 115 citations

Distribution of secretoneurin, a peptide derived from secretogranin II, in rat brain: An immunocytochemical and radioimmunological study

1993 • 113 citations

Chromogranin-reactive endocrine cells in argyrophilic carcinomas ("carcinoids") and normal tissue of the breast.

1985 • 113 citations

Chromogranin A in children with neuroblastoma. Serum concentration parallels disease stage and predicts survival.

1990 • 111 citations

Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression

1991 • 109 citations

Immunological Studies on the Occurrence and Properties of Chromogranin A and B and Secretogranin II in Endocrine Tumors

1988 • 106 citations

Presence of chromogranin A, B and C in bovine endocrine and nervous tissues: A comparative immunohistochemical study

1986 • 103 citations

Neuroendocrine differentiation in prostatic carcinomas. A retrospective autopsy study.

1988 • 101 citations

Chromogranin B (secretogranin I), a secretory protein of the regulated pathway, is also present in a tightly membrane-associated form in PC12 cells.

1992 • 101 citations

Small cel neuroendocrine carcinoma of the colon and rectum: Clinical, histologic, and ultrastructural study and immunohistochemical comparison with cloacogenic carcinoma

1987 • 100 citations

Medullary carcinoma of the thyroid. An immunocytochemical and histochemical study of 25 cases using eight separate markers

1985 • 99 citations

Chromogranin A (CGA) in the gastro-entero-pancreatic (GEP) endocrine system

1986 • 99 citations

Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10)

1987 • 98 citations

Pancreastatin, a Presumed Product of Chromogranin-A (Secretory Protein-I) Processing, Inhibits Secretion from Porcine Parathyroid Cells in Culture*

1989 • 96 citations

Synaptophysin immunoreactivity and small clear vesicles in neuroendocrine cells and related tumours

1987 • 95 citations

Identification of a peptide arising from the specific post‐translation processing of secretogranin II

1991 • 95 citations

Identification of gastroenteropancreatic neuroendocrine cells in normal and neoplastic human tissue with antibodies against synaptophysin, chromogranin A, secretogranin I (chromogranin B), and secretogranin II

1988 • 95 citations

Chromogranin B (secretogranin I), a putative precursor of two novel pituitary peptides through processing at paired basic residues

1987 • 94 citations

Hormone-Negative, Chromogranin a-Positive Endocrine Tumors

1989 • 93 citations

Paragangliomas of the head and neck: immunohistochemical neuroendocrine and intermediate filament typing.

1988 • 93 citations

Interaction of calcium with porcine adrenal chromogranin A (secretory protein-I) and chromogranin B (secretogranin I)

1989 • 92 citations

Small cell carcinoma of the major salivary glands: An immunohistochemical study

1990 • 91 citations

Sequence analysis, tissue distribution and regulation by cell depolarization, and second messengers of bovine secretogranin II (chromogranin C) mRNA.

1990 • 90 citations

Chromogranin A can act as a reversible processing enzyme inhibitor

1987 • 89 citations

Chromogranins A and B are co-localized with atrial natriuretic peptides in secretory granules of rat heart.

1990 • 88 citations

Chromogranin A: Posttranslational Modifications in Secretory Granules

1991 • 86 citations

A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease

1990 • 85 citations

A comparison of synaptophysin, chromogranin, and L-dopa decarboxylase as markers for neuroendocrine differentiation in lung cancer cell lines.

1990 • 82 citations

Chromogranin A-like immunoreactive neurites are major constituents of senile plaques.

1991 • 81 citations

Processing of chromogranin A within chromaffin granules starts at C‐ and N‐terminal cleavage sites

1988 • 78 citations

Chromogranin A (CgA) in the gastro-entero-pancreatic (GEP) endocrine system

1989 • 78 citations

Chromogranin in bronchopulmonary neuroendocrine cells. Immunocytochemical detection in human, monkey, and pig respiratory mucosa.

1987 • 77 citations

Biosynthesis of betagranin in pancreatic β-cells. Identification of a chromogranin A-like precursor and its parallel processing with proinsulin

1987 • 76 citations

Chromogranin A and B messenger ribonucleic acids in pituitary and other normal and neoplastic human endocrine tissues.

1989 • 75 citations

1B1075: a brain- and pituitary-specific mRNA that encodes a novel chromogranin/secretogranin-like component of intracellular vesicles

1990 • 70 citations

Endocrine cells and prognosis in patients with colorectal carcinoma

1992 • 70 citations

Synaptophysin

1987 • 69 citations

Topology of chromogranin A and secretogranin II in the rat anterior pituitary: potential marker proteins for distinct secretory pathways in gonadotrophs

1991 • 69 citations

The molecular cloning of the chromogranin A‐like precursor of β‐granin and pancreastatin from the endocrine pancreas

1988 • 69 citations

Markers for neural and endocrine cells

1991 • 68 citations

Calcium binding to chromaffin vesicle matrix proteins: effect of pH, magnesium, and ionic strength

1986 • 68 citations

Pancreastatin: Molecular and Immunocytochemical Characterization of a Novel Peptide in Porcine and Human Tissues*

1988 • 67 citations

Gastric Endocrine Cell Hyperplasia and Carcinoid Tumors in Atrophic Gastritis Type A

1987 • 67 citations

Diagnostic Immunohistochemistry of Neuroblastic Tumors

1992 • 66 citations

Chromogranin A-like immunoreactivity in the human brain: Distribution in bulbar medulla and cerebral cortex

1990 • 65 citations

The organisation of the mouse chromogranin B (secretogranin I) gene

1990 • 65 citations

Chapter 20 Multiple messenger candidates and marker substances in the mammalian Merkel cell – axon complex: a light and electron microscopic immunohistochemical study

1988 • 63 citations

Calcium-binding and aggregation properties of parathyroid secretory protein-I (chromogranin A).

1988 • 63 citations

Chromogranin A and B and Secretogranin II in Medullary Carcinomas of the Thyroid

1987 • 63 citations

Pituitary adenomas. An immunohistochemical study of hormone production and chromogranin localization.

1984 • 63 citations

Comparison of chromogranins A, B, and secretogranin II in human adrenal medulla and pheochromocytoma.

1987 • 58 citations

Primary Carcinoid Tumor of the Liver

1988 • 58 citations

Endocrine Markers in Argyrophilic Carcinomas of the Breast

1987 • 57 citations

Carcinoid tumors of the thymus. An immunohistochemical study

1987 • 57 citations

The neuroendocrine and neural profiles of neuroblastomas, ganglioneuroblastomas, and ganglioneuromas.

1990 • 57 citations

Neuroendocrine Differentiation in Müllerian Neoplasms: An Immunohistochemical Study of a “Pure” Endometrial Small-Cell Carcinoma and a Mixed Müllerian Tumor Containing Small-Cell Carcinoma

1986 • 57 citations

Immunohistochemical study of chromogranin in 100 cases of pheochromocytoma, carotid body tumour, medullary thyroid carcinoma and carcinoid tumour

1988 • 56 citations

Co-localization of secretogranins/chromogranins with thyrotropin and luteinizing hormone in secretory granules of cow anterior pituitary.

1990 • 56 citations

Divergent changes of chromogranin A/secretogranin II levels in differentiating human neuroblastoma cells

1990 • 55 citations

Co-localization of chromogranin A and B, secretogranin II and neuropeptide Y in chromaffin granules of rat adrenal medulla studied by electron microscopic immunocytochemistry

1989 • 54 citations

The Bovine Chromogranin A Gene: Structural Basis for Hormone Regulation and Generation of Biologically Active Peptides

1991 • 54 citations

Non-small cell lung carcinomas with neuroendocrine features. A light microscopic, immunohistochemical and ultrastructural study of 11 cases

1988 • 54 citations

Neuroendocrine Sources of Chromogranin-A in Normal Man: Clues from Selective Stimulation of Endocrine Glands*

1990 • 53 citations

Monodendritic neurons: a cell type in the human cerebellar cortex identified by chromogranin A-like immunoreactivity

1990 • 53 citations

Chromostatin, a chromogranin A-derived bioactive peptide, is present in human pancreatic insulin (beta) cells.

1993 • 53 citations

Argyrophilia and Granin (Chromogranin/Secretogranin) Expression in Female Breast Carcinomas Their Relationship to Survival and Other Disease Parameters

1992 • 53 citations

Chromogranin A and B and secretogranin II in bronchial and intestinal carcinoids

1987 • 52 citations

Endocrine differentiation of gastric adenocarcinoma. The prevalence as evaluated by immunoreactive chromogranin a and its biologic significance

1988 • 52 citations

Glucocorticoid- and Nerve Growth Factor-Induced Changes in Chromogranin A Expression Define Two Different Neuronal Phenotypes in PC12 Cells

1988 • 51 citations

Chromogranin as a Marker of Neuroendocrine Cells in Cytologic Material—An Immunocytochemical Study

1985 • 50 citations

Solid-cystic tumour of the pancreas

1990 • 50 citations

Gastroenteropancreatic Neuroendocrine Tumors: A Histochemical and Immunohistochemical Study of Epithelial (keratin proteins, carcinoembryonic antigen) and Neuroendocrine (neuron-specific enolase, bombesin and chromogranin) Markers in Foregut, Midgut, and Hindgut Tumors

1986 • 49 citations

Immunocytochemical characterization of 10 pancreatic tumours, associated with the glucagonoma syndrome, using antibodies to separate regions of the pro‐glucagon molecule and other neuroendocrine markers

1986 • 48 citations

Strumal carcinoids of the ovary. An immunohistologic and ultrastructural study.

1987 • 48 citations

An immunological study on chromogranin A and B in human endocrine and nervous tissues

1989 • 47 citations

Electron microscopic localization of chromogranin A in osmium-fixed neuroendocrine cells with a protein A-gold technique.

1987 • 47 citations

The organisation of the mouse secretogranin II gene

1992 • 46 citations

Immunohistochemical localization of chromogranin in human hypophyses and pituitary adenomas.

1985 • 46 citations

Nonsecretory parathyroid carcinoma of the mediastinum. Light microscopic, immunocytochemical, and ultrastructural features of a case, and review of the literature

1986 • 45 citations

Isolation of human pancreastatin fragment containing the active sequence from a glucagonoma

1988 • 45 citations

Immunohistochemical Identification of Exocrine and Neuroendocrine Subsets of Large Cell Lung Carcinomas

1988 • 45 citations

Detection of Chromogranins A and B in Endocrine Tissues with Radioactive and Biotinylated Oligonucleotide Probes

1990 • 44 citations

Effect of Pancreastatin on Pancreatic Endocrine and Exocrine Secretion

1989 • 44 citations

Comparative study of seven neuroendocrine markers in pancreatic endocrine tumours

1988 • 44 citations

Adenomatous Tumor of the Middle Ear: An Ultrastructural and Immunocytochemical Study

1985 • 44 citations

A comparative immunohistochemical study of jejunoileal and appendiceal carcinoids. Implications for histogenesis and pathogenesis

1992 • 43 citations

Endocrine and tumor differentiation markers in poorly differentiated small-cell carcinoids of the cervix and vagina.

1986 • 43 citations

Chromostatin receptors control calcium channel activity in adrenal chromaffin cells.

1992 • 42 citations

Dexamethasone induces an increased biosynthesis of chromogranin A in rat pituitary gland

1989 • 42 citations

Suppression of Chromogranin-A Release from Neuroendocrine Sources in Man: Pharmacological Studies*

1991 • 42 citations

Isolation of peptides arising from the specific posttranslational processing of chromogranin A and chromogranin B from human pheochromocytoma tissue

1992 • 41 citations

Chromogranin A in the Mammalian Merkel Cell: Cellular and Subcellular Distribution

1989 • 41 citations

Human Pituitary Tumors Secrete Chromogranin-A*

1989 • 41 citations

Cardiac paragangliomas

1985 • 40 citations

Rapid publication a chromogranin a-derived peptide differentially regulates the secretion of calcitonin gene products

1990 • 39 citations

Tangle-associated neuritic clusters. A new lesion in Alzheimer's disease and aging suggests that aggregates of dystrophic neurites are not necessarily associated with beta/A4.

1992 • 39 citations

Chromogranin a immunoreactivity compared with argyrophilia, calcitonin immunoreactivity, and amyloid as tumour markers in the histopathological diagnosis of medullary (C-cell) thyroid carcinoma

1992 • 38 citations

A study of different markers for neuroendocrine differentiation in breast carcinomas

1986 • 37 citations

Chromogranin A and B in Adenomas of the Pituitary

1991 • 35 citations

Pancreastatin: A novel peptide inhibitor of parietal cell signal transduction

1989 • 35 citations

Composite gastric carcinoma. Report of a tumor of the carcinoma-carcinoid spectrum.

1988 • 35 citations

Differential regulation of chromogranin B/secretogranin I and secretogranin II by forskolin in PC12 cells

1992 • 35 citations

Expression of chromogranin a mRNA in small cell carcinoma of the lung

1991 • 34 citations

Effects of Sandostatin on Plasma Chromogranin-A Levels in Neuroendocrine Tumors*

1989 • 33 citations

Subcellular distribution of secretogranins I and II in GH3 rat tumoral prolactin (PRL) cells as revealed by electron microscopic immunocytochemistry.

1989 • 33 citations

Chromogranin A and B gene expression in carcinomas of the breast. Correlation of immunocytochemical, immunoblot, and hybridization analyses.

1990 • 32 citations

Preparation and characterization of anti-human chromogranin A and chromogranin B (secretogranin I) monoclonal antibodies

1989 • 32 citations

Neurofilament and chromogranin expression in normal and neoplastic neuroendocrine cells of the human gastrointestinal tract and pancreas

1990 • 32 citations

Immunohistochemical comparison of chromogranins A and B and secretogranin II with calcitonin and calcitonin gene‐related peptide expression in normal, hyperplastic and neoplastic C‐cells of the human thyroid

1992 • 32 citations

Immunoreactivity of hormonally-characterized human endocrine cells against three novel anti-human chromogranin B(B11 and B13) and chromogranin A (A11) monoclonal antibodies.

1989 • 31 citations

Chromogranin A and B in parathyroid tissue of cases of primary hyperparathyroidism: an immunohistochemical study

1991 • 30 citations

Neuroendocrine differentiation in poorly differentiated lung carcinomas: a light microscopic and immunohistologic study.

1990 • 29 citations

Immunohistochemical and immunoelectron microscopic demonstration of chromogranin A in formalin-fixed tissue of Merkel cell carcinoma

1993 • 29 citations

Widespread occurrence of chromogranins/secretogranins in the matrix of secretory granules of endocrinologically silent pituitary adenomas.

1992 • 29 citations

Immunohistochemical demonstration of chromogranins A and B in neuroendocrine tumors of the lung

1992 • 29 citations

Calcitonin and chromogranin A localization in medullary carcinoma of the thyroid by immunoelectron microscopy.

1988 • 28 citations

Immunocytochemical localization of synaptophysin in human hypophyses and pituitary adenomas.

1988 • 27 citations

Primary thymic carcinoid with Cushing's syndrome

1992 • 27 citations

Secretogranin I/Chromogranin B Is a Heparin‐Binding Adhesive Protein

1992 • 26 citations

Differentiation of human pituitary adenomas determines the pattern of chromogranin/secretogranin messenger ribonucleic acid expression.

1993 • 26 citations

Immunochemical characterization of a novel secretory protein (defined by monoclonal antibody HISL-19) of peptide hormone producing cells which is distinct from chromogranin A, B, and C.

1988 • 26 citations

Chromogranin A, chromogranin B and secretogranin II mRNAs in the pituitary and adrenal glands of various mammals. Regulation of chromogranin A, chromogranin B and secretogranin II mRNA levels by estrogen.

1992 • 25 citations

The occurrence of pancreastatin in tumours of the diffuse neuroendocrine system

1988 • 25 citations

Chromostatin inhibits catecholamine secretion in adrenal chromaffin cells by activating a protein phosphatase.

1992 • 25 citations

Small cell neuroendocrine carcinoma of the urinary bladder

1988 • 25 citations

Medullary carcinoma of the thyroid as a cause of cushing's syndrome: A case with ectopic adrenocorticotropin secretion characterized by double enzyme immunostaining

1992 • 23 citations

Immunohistochemical study of nodular hyperplastic parathyroid glands in patients with secondary hyperparathyroidism

1988 • 23 citations

Sites of synthesis of chromogranins A and B in the human brain

1992 • 23 citations

Gonadotropin-Releasing Hormone Regulates Gonadotropinβ-Subunit and Chromogranin-B Messenger Ribonucleic Acids in Cultured Chromogranin-A-Positive Pituitary Adenomas*

1990 • 21 citations

Chromogranin A-processing proteinases in purified chromaffin granules: contaminants or endogenous enzymes?

1990 • 21 citations

Immunohistochemical demonstration of chromogranin in endometrial carcinomas with argyrophil cells

1986 • 21 citations

Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating human neuroblastoma cells.

1992 • 20 citations

Chromogranin A, a soluble synaptic vesicle protein, is found in cortical neurons other than previously defined peptidergic neurons in the human neocortex

1993 • 20 citations

Ultrastructural identification of human secretin cells by the immunogold technique. Their costorage of chromogranin A and serotonin

1990 • 20 citations

The distribution of GAWK-like immunoreactivity in neuroendocrine cells of the human gut, pancreas, adrenal and pituitary glands and its co-localisation with chromogranin B

1989 • 19 citations

Intriguing Case: Argyrophilic Neuroendocrine Carcinoma of the Male Breast

1993 • 18 citations

In situ hybridization study of chromogranin A and B mRNA in carcinoid tumors

1991 • 16 citations

Immunodetection of secretogranin II in animal and human tissues by new monoclonal antibodies

1992 • 16 citations

Secretogranin II is a Ca-binding protein

1988 • 15 citations

Immunohistochemical identification of neuron-specific enolase, synaptophysin, chromogranin and endocrine granule constituent in neuroendocrine tumours.

1990 • 15 citations

Markers for Neural and Endocrine Cells. Molecular and Cell Biology, Diagnostic Applications

1992 • 14 citations

Ultrastructural localization of prolactin and chromogranin B messenger ribonucleic acids with biotinylated oligonucleotide probes in cultured pituitary cells.

1990 • 13 citations

[Primary carcinoid of the liver].

1982 • 2 citations