Chromogranin A-processing proteinases in purified chromaffin granules: contaminants or endogenous enzymes?

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Proteinases in mammalian cells and tissues

1978 • 981 citations

Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion

1986 • 686 citations

Secretion of a Chromaffin Granule Protein, Chromogranin, from the Adrenal Gland after Splanchnic Stimulation

1967 • 523 citations

A simple method for the isolation of adrenal chromaffin granules on a large scale

1967 • 439 citations

The composition of adrenal chromaffin granules: An assessment of controversial results

1976 • 435 citations

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases

1988 • 403 citations

The molecular function of adrenal chromaffin granules: Established facts and unresolved topics

1986 • 358 citations

Purification and properties of an acidic protein from chromaffin granules of bovine adrenal medulla

1967 • 332 citations

Bovine chromogranin A sequence and distribution of its messenger RNA in endocrine tissues

1986 • 314 citations

Biochemistry of the enkephalins and enkephalin-containing peptides

1983 • 270 citations

The primary structure of bovine chromogranin A: a representative of a class of acidic secretory proteins common to a variety of peptidergic cells.

1986 • 253 citations

Chromogranin A, the major catecholamine storage vesicle soluble protein. Multiple size forms, subcellular storage, and regional distribution in chromaffin and nervous tissue elucidated by radioimmunoassay.

1984 • 217 citations

The biogenesis of adrenal chromaffin granules

1977 • 203 citations

THE SEQUENCE OF PORCINE CHROMOGRANIN A MESSENGER RNA DEMONSTRATES CHROMOGRANIN A CAN SERVE AS THE PRECURSOR FOR THE BIOLOGICALLY ACTIVE HORMONE, PANCREASTATIN

1988 • 199 citations

Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles.

1985 • 179 citations

Immunological Characterization of Secretory Proteins of Chromaffin Granules: Chromogranins A, Chromogranins B, and Enkephalin‐Containing Peptides

1985 • 160 citations

Immunological studies on the distribution of chromogranin A and B in endocrine and nervous tissues

1985 • 154 citations

Some chemical and physical properties of the soluble protein fraction of bovine adrenal chromaffin granules.

1966 • 142 citations

Cathepsin D isozymes from porcine spleens. Large scale purification and polypeptide chain arrangements.

1979 • 127 citations

Presence of chromogranin A, B and C in bovine endocrine and nervous tissues: A comparative immunohistochemical study

1986 • 103 citations

Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10)

1987 • 98 citations

Cathepsin B-related proteases in the insulin secretory granule.

1984 • 89 citations

The localization of lysosomal enzymes in chromaffin tissue

1966 • 84 citations

A “trypsin-like” enzyme in adrenal chromaffin granules: A proenkephalin processing enzyme

1982 • 83 citations

Enkephalin convertase: A specific enkephalin synthesizing carboxypeptidase in adrenal chromaffin granules, brain, and pituitary gland

1982 • 83 citations

Isolation and Immunological Characterization of a Glycoprotein from Adrenal Chromaffin Granules

1984 • 83 citations

Isolation and Characterization of Chromogranins A, B, and C from Bovine Chromaffin Granules and a Rat Pheochromocytoma

1987 • 82 citations

Processing of chromogranin A within chromaffin granules starts at C‐ and N‐terminal cleavage sites

1988 • 78 citations

Cell-free and cellular synthesis of chromogranin A and B of bovine adrenal medulla

1985 • 75 citations

Dopamine β‐Hydroxylase and Other Glycoproteins from the Soluble Content and the Membranes of Adrenal Chromaffin Granules: Isolation and Carbohydrate Analysis

1982 • 74 citations

Relationship of multiple forms of chromogranin.

1985 • 72 citations

Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules

1987 • 69 citations

Further Characterization of an Enkephalin‐Generating Enzyme from Adrenal Medullary Chromaffin Granules

1984 • 66 citations

Biogenesis of Chromaffin Granules: Incorporation of Sulfate into Chromogranin B and into a Proteoglycan

1985 • 63 citations

Immunological studies on the acidic chromogranins and on dopamine β hydroxylase (EC 1.14.2.1) of bovine chromaffin granules

1974 • 61 citations

A putative prohormone processing protease in bovine adrenal medulla specifically cleaving in between Lys-Arg sequences

1985 • 55 citations

An increased pool of secretory hormones and peptides in adrenal medulla of stroke-prone spontaneously hypertensive rats.

1989 • 48 citations

Biosynthetic relationship between the major matrix proteins of adrenal chromaffin granules

1983 • 44 citations

Immunological characterization of chromogranins A and B and secretogranin II in the bovine pancreatic islet

1987 • 41 citations

Identification of two glycoproteins of chromaffin granules as the carboxypeptidase H

1986 • 39 citations

A specific soluble protein from the catecholamine storage vesicles of bovine adrenal medulla II. Physical characterization

1969 • 37 citations

Processing of enkephalin precursors by chromaffin granule enzymes

1982 • 31 citations

Differential Distribution of Carboxypeptidase‐Processing Enzyme Activity and Immunoreactivity in Membrane and Soluble Components of Chromaffin Granules

1985 • 30 citations

Immunological characterization of a membrane glycoprotein of chromaffin granules: Its presence in endocrine and exocrine tissues

1988 • 24 citations

Effects of calcium and limited proteolysis on membrane‐bound and releasable dopamine β‐hydroxylase in adrenomedullary catecholamine granules

1985 • 5 citations