The new generation of antipsychotic drugs

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

The Mechanism of Action of Novel Antipsychotic Drugs

1991 • 410 citations

D1, D2, and 5-HT2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients

1995 • 341 citations

Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response.

1994 • 334 citations

Mechanisms of action of atypical antipsychotic drugs: a critical analysis

1996 • 315 citations

Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity.

1994 • 304 citations

The D2 dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: A pet study

1995 • 237 citations

Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle

1991 • 189 citations

Seroquel restores sensorimotor gating in phencyclidine-treated rats.

1996 • 156 citations

Positron Emission Tomography Studies on D2 and 5-HT2 Receptor Binding in Risperidone-Treated Schizophrenic Patients

1995 • 156 citations

Effects of Olanzapine on Regional C-Fos Expression in Rat Forebrain

1996 • 140 citations

A PET Study of 5-HT2 and D2 Dopamine Receptor Occupancy Induced by Olanzapine in Healthy Subjects

1997 • 132 citations

Electrophysiological Effects of Olanzapine, a Novel Atypical Antipsychotic, on A9 and A10 Dopamine Neurons

1996 • 122 citations

Seroquel: electrophysiological profile of a potential atypical antipsychotic

1993 • 117 citations

Drug treatment of the negative symptoms of schizophrenia

1998 • 93 citations

Electrophysiological profile of the new atypical neuroleptic, sertindole, on midbrain dopamine neurones in rats: Acute and repeated treatment

1992 • 86 citations

The time course of binding to striatal dopamine D2 receptors by the neuroleptic ziprasidone (CP-88,059-01) determined by positron emission tomography

1996 • 84 citations

A comparison of an atypical and typical antipsychotic, zotepine versus haloperidol in patients with acute exacerbation of schizophrenia: a parallel-group double-blind trial.

1996 • 75 citations

Clozapine increases rat serum prolactin levels

1975 • 71 citations

Dopamine, acetylcholine, and GABA effects in acute dystonia in primates

1980 • 68 citations

IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol

1997 • 68 citations

Acute antagonism of dopamine D2-like receptors by amisulpride: Effects on hormone secretion in healthy volunteers

1994 • 64 citations

Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone.

1996 • 57 citations

Zotepine vs. haloperidol in paranoid schizophrenia: a double-blind trial.

1989 • 53 citations

Dopamine D2 receptor blockade in vivo with the novel antipsychotics risperidone and remoxipride — an123I-IBZM single photon emission tomography (SPET) study

1995 • 51 citations

Stimulation by risperidone of rat prolactin secretion in vivo and in cultured pituitary cells in vitro.

1992 • 43 citations

Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat

1987 • 36 citations

Clinical and Neuroendocrine Effects of Zotepine - A New Neuroleptic Drug

1987 • 32 citations

Antipsychotic drug mechanisms and neurotransmitter systems in schizophrenia

1994 • 31 citations

Dopamine, PIF, and other regulators of prolactin secretion.

1980 • 28 citations

D-1 dopamine receptor stimulaiton elevates plasma prolactin levels

1986 • 26 citations

New Approaches to the Drug Treatment of Schizophrenia

1995 • 25 citations

P-4-65 Time course for dopamine and serotonin receptor occupancy in the brain of schizophrenic patients following dosing with 150 mg Seroquel™ tid

1995 • 17 citations

Effect of substituted benzamides on prolactin secretion in the rat

1992 • 7 citations