The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Obesity and the Environment: Where Do We Go from Here?

2003 • 2,205 citations

Hypothalamic mTOR Signaling Regulates Food Intake

2006 • 1,217 citations

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

2003 • 1,003 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

The Two TORCs and Akt

2007 • 782 citations

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

2004 • 716 citations

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

1998 • 636 citations

Molecular and anatomical determinants of central leptin resistance

2005 • 543 citations

Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance

2004 • 536 citations

A Controlled High-Fat Diet Induces an Obese Syndrome in Rats

2003 • 526 citations

Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity

2001 • 301 citations

Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle

2006 • 279 citations

Monitoring of stored and available fuel by the CNS: implications for obesity

2003 • 231 citations

A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss

2007 • 211 citations

The role of leptin in leptin resistance and obesity

2006 • 188 citations

Genetic factors in human obesity

2007 • 185 citations

Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet

2004 • 157 citations

Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance

2005 • 151 citations

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

2002 • 130 citations

Understanding global nutrition dynamics as a step towards controlling cancer incidence

2006 • 97 citations

Mice lacking the syndecan-3 gene are resistant to diet-induced obesity

2004 • 89 citations

Hypothalamic Phosphatidylinositol 3-Kinase Pathway of Leptin Signaling Is Impaired during the Development of Diet-Induced Obesity in FVB/N Mice

2007 • 83 citations

Ciliary Neurotrophic FactorAx15 Alters Energy Homeostasis, Decreases Body Weight, and Improves Metabolic Control in Diet-Induced Obese and UCP1-DTA Mice

2004 • 61 citations

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

2002 • 30 citations

Mice lacking the syndecan-3 gene are resistant to diet-induced obesity

2004 • 12 citations