Propentofylline: A nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia

The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

1990 • 2,204 citations

Cytotoxicity of microglia

1993 • 1,042 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Selective vulnerability in the gerbil hippocampus following transient ischemia

1984 • 562 citations

Delayed neuronal death in the rat hippocampus following transient forebrain ischemia

1984 • 349 citations

Adenosine and Brain Ischemia

1995 • 298 citations

Cardiovascular effects of adenosine in man; possible clinical implications

1986 • 227 citations

Adenosine in the Nervous System

1991 • 179 citations

Ischemia-Induced Neuronal Cell Death, Calcium Accumulation, and Glial Response in the Hippocampus of the Mongolian Gerbil and Protection by Propentofylline (HWA 285)

1987 • 168 citations

Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus

1990 • 164 citations

Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family.

1992 • 163 citations

Sodium-dependent nucleoside transport in mouse intestinal epithelial cells. Two transport systems with differing substrate specificities.

1988 • 159 citations

Effect of Theophylline on Ischemically Induced Hippocampal Damage in Mongolian Gerbils: A Behavioral and Histopathological Study

1987 • 145 citations

Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia

1990 • 143 citations

Ischaemic damage in gerbil hippocampus is reduced following upregulation of adenosine (A1) receptors by caffeine treatment

1989 • 118 citations

Modulation of Intracellular Formation of Reactive Oxygen Intermediates in Peritoneal Macrophages and Microglia/Brain Macrophages by Propentofylline

1994 • 107 citations

Quantitative autoradiographic analysis of muscarinic cholinergic and adenosine A1 binding sites after transient forebrain ischemia in the gerbil

1987 • 106 citations

Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles

1991 • 105 citations

Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation

1994 • 101 citations

Transient ischemia stimulates glial fibrillary acid protein and vimentin gene expression in the gerbil neocortex, striatum and hippocampus

1992 • 94 citations

Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells

1990 • 89 citations

Propentofylline and Other Adenosine Transport Inhibitors Increase the Efflux of Adenosine Following Electrical or Metabolic Stimulation of Rat Hippocampal Slices

1994 • 77 citations

The Xanthine Derivative 1‐(5′‐Oxohexyl)‐3‐methyl‐7‐propyl Xanthine (HWA 285) Enhances the Actions of Adenosine

1986 • 71 citations

Protection against ischemic brain damage using propentofylline in gerbils.

1988 • 69 citations

Pharmacokinetics of oral dipyridamole (Persantine�) and its effect on platelet adenosine uptake in man

1982 • 68 citations

Propentofylline (HWA 285) protects hippocampal neurons of Mongolian gerbils against ischemic damage in the presence of an adenosine antagonist

1988 • 64 citations

Effects of long-term theophylline treatment on adenosine A1-receptors in rat brain: autoradiographic evidence for increased receptor number and altered coupling to G-proteins

1990 • 63 citations

ADENOSINE TRANSPORT IN NERVOUS SYSTEM TISSUES

1991 • 57 citations

Effects of propentofylline on adenosine A1 and A2 receptors and nitrobenzylthiojnosine-sensitive nucleoside transporters: Quantitative autoradiographic analysis

1991 • 52 citations

Effect of Propentofylline on Regional Cerebral Glucose Metabolism in Acute Ischemic Stroke

1993 • 48 citations

Inhibitory effects of propentofylline on [3H]adenosine influx

1993 • 48 citations

Cerebral ischemia in gerbils: Postischemic administration of cyclohexyl adenosine and 8-sulfophenyl-theophylline

1990 • 46 citations

Calcium antagonist, adenosine A1, and muscarinic bindings in rat hippocampus after transient ischemia.

1990 • 35 citations

Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport

1992 • 34 citations

How does dipyridamole elevate extracellular adenosine concentration? Predictions from a three-compartment model of adenosine formation and inactivation

1986 • 34 citations

Propentofylline and postischemic brain edema: Relation to Na⁺‐K⁺‐ATPase activity

1985 • 27 citations

Characterization of the uptake of adenosine by cultured rat hippocampal cells and inhibition of the uptake by xanthine derivatives

1991 • 26 citations

Adenosine: its relevance to the treatment of brain ischemia and trauma.

1990 • 24 citations

Impairment of learning and memory and the accessory symptom in aged rat as senile dementia model (3): Oral administration of propentofylline produces recovery of reduced NGF content in the brain of aged rats.

1993 • 22 citations

Propentofylline and a Hydroxy Metabolite Augment A₂‐Receptor Mediated Cyclic AMP Accumulation and Attenuate A₁‐Receptor Mediated Inhibition of Acetylcholine Release in the Rat Hippocampus

1989 • 21 citations

Effects of propentofylline on energy metabolism of the ischemic brain studied by in vivo 31P nuclear magnetic resonance spectroscopy.

1989 • 15 citations

Effect of propentofylline on ischemia-induced loss of muscarinic cholinergic receptor binding in the gerbil hippocampus.

1992 • 5 citations

Autoradiographical Studies of in Vitro and Chronic in Vivo Effects of Propentofylline on Adenosine A1and A2Receptors and NBMPR-Sensitive Nucleoside Transporters

1991 • 3 citations