Elementary steps in enzyme catalysis and regulation

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

The Enzymology of Control by Feedback Inhibition

1962 • 1,003 citations

THE HEMOGLOBIN SYSTEM

1925 • 813 citations

Kinetic Aspects of Regulation of Metabolic Processes

1970 • 616 citations

Investigation of rates and mechanisms of reactions

1961 • 612 citations

Tertiary Structure of Ribonuclease

1967 • 573 citations

The Sequence of Amino Acid Residues in Bovine Pancreatic Ribonuclease: Revisions and Confirmations

1963 • 562 citations

Distinct Subunits for the Regulation and Catalytic Activity of Aspartate Transcarbamylase^*

1965 • 541 citations

Protonenübertragung, Säure-Base-Katalyse und enzymatische Hydrolyse. Teil I: Elementarvorgänge

1963 • 468 citations

24 Bovine Pancreatic Ribonuclease

1971 • 437 citations

The Sequence of the Amino Acid Residues in Performic Acid-oxidized Ribonuclease

1960 • 428 citations

Allosteric Interactions in Aspartate Transcarbamylase. II. Evidence for Different Conformational States of the Protein in the Presence and Absence of Specific Ligands

1968 • 316 citations

New Structural Model of E. coli Aspartate Transcarbamylase and the Amino-acid Sequence of the Regulatory Polypeptide Chain

1968 • 276 citations

P-Fructokinase and the control of the citric acid cycle

1963 • 272 citations

A Theoretical Study of the Binding of Small Molecules to a Polymerizing Protein System. A Model for Allosteric Effects^*

1967 • 214 citations

Properties and Conformation of the Histidine Residues at the Active Site of Ribonuclease

1963 • 201 citations

7 The Molecular Basis for Enzyme Regulation

1970 • 177 citations

Relaxation Spectrometry of Biological Systems

1968 • 163 citations

Subunit Structure of Aspartate Transcarbamylase from Escherichia coli

1971 • 158 citations

Glutamate Dehydrogenase Concentration as a Determinant in the Effect of Purine Nucleotides on Enzymatic Activity

1967 • 157 citations

The active site and mechanism of action of bovine pancreatic ribonuclease. 3. The pH-dependence of the kinetic parameters for the hydrolysis of cytidine 2′,3′-phosphate

1962 • 150 citations

Geometry of the First Step in the Action of Ribonuclease-A

1972 • 142 citations

THE MECHANISM OF ACTION OF RIBONUCLEASE

1969 • 137 citations

Absolute Stereochemistry of the Second Step of Ribonuclease Action

1970 • 132 citations

An Investigation of Water-Urea and Water-Urea-Polyethylene Glycol Interactions

1967 • 131 citations

A Discussion of the Regulatory Properties of Aspartate Transcarbamylase from Escherichia coli

1970 • 130 citations

2 Rapid Reactions and Transient States

1970 • 123 citations

A Reinvestigation of the Sequence of Residues 11 to 18 in Bovine Pancreatic Ribonuclease

1962 • 113 citations

The Reactivities of the Histidine Residues at the Active Site of Ribonuclease toward Halo Acids of Different Structures

1965 • 113 citations

Studies of the activity of chymotrypsin

1970 • 108 citations

Co-operative binding of nicotinamide-adenine dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase

1971 • 106 citations

The active site and mechanism of action of bovine pancreatic ribonuclease. 7. The catalytic mechanism

1962 • 103 citations

Alternative to allosterism and cooperativity in the interpretation of enzyme kinetic data

1968 • 102 citations

7 Aspartate Transcarbamylases

1973 • 100 citations

KINETICS OF ALLOSTERIC ENZYMES 9031

1974 • 99 citations

Regulation of Enzyme Activity

1971 • 83 citations

Relaxation Spectra of Ribonuclease. II. Isomerization of Ribonuclease at Neutral pH Values

1965 • 83 citations

Hybridization of Native and Chemically Modified Enzymes, III. The Catalytic Subunits of Aspartate Transcarbamylase

1970 • 81 citations

An Allosteric Reduced Nicotinamide Adenine Dinucleotide Oxidase from Mycobacterium tuberculosis

1965 • 79 citations

THE EFFECT OF pH ON FUMARASE ACTIVITY IN ACETATE BUFFER

1955 • 77 citations

Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with an adenosine 5'-triphosphate analog

1973 • 77 citations

The Function of the Pyrimidine Base in the Ribonuclease Reaction

1963 • 72 citations

Binding of cytidine triphosphate to aspartate transcarbamylase

1970 • 71 citations

Kinetics of the helix-coil transition in aqueous poly(L-glutamic acid)

1972 • 69 citations

Nuclear magnetic resonance studies of the structure and binding sites of enzymes. IV. Cytidine 3'-monophosphate binding to ribonuclease.

1968 • 68 citations

Kinetic and equilibrium studies of the ribonuclease-catalyzed hydrolysis of uridine 2',3'-cyclic phosphate

1969 • 67 citations

Threonine Deaminase from Bacillus subtilis

1970 • 66 citations

A Kinetic Study of the Hydrogen-Bond Dimerization of 2-Pyridone¹

1966 • 65 citations

Equilibrium binding study of the interaction of aspartate transcarbamylase with cytidine 5'-triphosphate and adenosine 5'-triphosphate

1973 • 65 citations

Porcine Heart Lactate Dehydrogenase

1969 • 63 citations

Relaxation spectra of adenosine triphosphate-creatine phosphotransferase

1969 • 61 citations

Kinetic and thermodynamic studies of hydrogen bonding

1969 • 61 citations

8 Mechanisms of Enzyme Regulation in Metabolism

1970 • 60 citations

Effect of Adenylic Acid on the Regulatory Nicotinamide-Adenine Dinucleotide Specific Isocitrate Dehydrogenase^*

1966 • 59 citations

Interaction of Aspartate Transcarbamylase with Regulatory Nucleotides

1973 • 55 citations

Relaxation spectra of aspartate transcarbamylase. Interaction of the catalytic subunit with carbamyl phosphate, succinate, and L-malate

1971 • 51 citations

Aspartate Transcarbamoylase from Escherichia coli : Electron Density at 5.5 Å Resolution

1973 • 50 citations

Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with aspartate analogs

1971 • 50 citations

Ultrasonic-Absorption Measurements in Mixed Solvents: Water—Dioxane

1966 • 48 citations

Cooperativity of solvent-macromolecule interactions in aqueous solutions of polyethylene glycol and polyethylene glycol-urea

1968 • 48 citations

Influence of Denaturing Agents on Solvent Structure^*

1967 • 46 citations

Spin-labeling studies of aspartate transcarbamylase. I. Effects of nucleotide binding and subunit separation

1970 • 46 citations

Relaxation spectra of aspartate transcarbamylase. I. Interaction of 5-bromocytidine triphosphate with native enzyme and regulatory subunit

1970 • 42 citations

Electron microscopy of aspartate transcarbamylase and its catalytic subunit

1972 • 42 citations

Relaxation spectra of ribonuclease. VII. Interaction of ribonuclease with uridine 2', 3'-cyclic phosphate

1970 • 42 citations

Interaction of aspartate transcarbamylase with 5-bromocytidine 5'-tri-, di-, and monophosphates

1974 • 39 citations

Kinetic and equilibrium study of the hydrogen bond dimerization of 2-pyridone in hydrogen bonding solvents

1970 • 37 citations

Ultrasonic Absorption in Aqueous Polyethylene Glycol Solutions¹

1966 • 37 citations

The rate of an allosteric process: inhibition of homoserine dehydrogenase I from E. coli by threonine.

1968 • 37 citations

Nuclear Magnetic Resonance Study of the Rotational Equilibrium in Acryloyl Fluoride

1966 • 33 citations

Kinetic Analysis of Allosteric Enzymes

1971 • 31 citations

Relaxation Spectra of Ribonuclease. V. The Interaction of Ribonuclease with Cytidylyl-3':5'-cytidine¹

1966 • 30 citations

Kinetics and Mechanism of the Base Catalyzed Hydration of Fumarate to Malate

1959 • 23 citations

Rate constants for the dissociation of amine-water hydrogen bonds and the effect of nonpolar groups in aqueous solution

1967 • 21 citations

A Thermodynamic Study of the Hydrolysis of Cytidine 2‘,3‘-Cyclic Phosphate

1965 • 20 citations

Relaxation spectra of aspartate transcarbamylase. Interaction of the native enzyme with cytidine 5'-triphosphate

1973 • 15 citations

Kinetics of the Acid Catalysis of the Hydration of Fumaric Acid to Malic Acid

1957 • 15 citations

Ultrasonic absorption measurements in aqueous solutions of glycine, diglycine, and triglycine

1968 • 13 citations

Elementary steps in enzyme catalysis and regulation

1974 • 7 citations