Comparison of several benzodiazepine receptor ligands in two models of anxiolytic activity in the mouse: an analysis based on fractional receptor occupancies

Statistical principles in experimental design.

1962 • 27,228 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

1984 • 951 citations

Novel anxiolytics that act as partial agonists at benzodiazepine receptors

1990 • 276 citations

Evaluation of a rapid technique for detecting minor tranquilizers

1971 • 169 citations

GABAergic Synaptic Transmission

2006 • 148 citations

Abecarnil, a metabolically stable, anxioselective beta-carboline acting at benzodiazepine receptors.

1990 • 130 citations

A new method for rapid screening of minor tranquillizers in mice

1968 • 124 citations

Does the excitatory amino acid receptor antagonist 2-APH exhibit anxiolytic activity?

1986 • 123 citations

Progress in Psychobiology and Physiological Psychology, Vol. 8

1980 • 118 citations

Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions.

1987 • 91 citations

Ro 16-6028: A Novel Anxiolytic Acting as a Partial Agonist at the Benzodiazepine Receptor

1988 • 91 citations

The effect of benzodiazepines and β-carbolines on gabastimulated chloride influx by membrane vesicles from the rat cerebral cortex

1986 • 86 citations

Tolerance to the benzodiazepine diazepam in an animal model of anxiolytic activity

1985 • 86 citations

Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio.

1990 • 84 citations

Pharmacological and Behavioral Profile of Alpidem as an Anxiolytic

1990 • 83 citations

Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies.

1992 • 82 citations

Time course of ethanol's effects on locomotor activity, exploration and anxiety in mice

1988 • 76 citations

Selectivity for Omega-Receptor Subtypes as a Strategy for the Development of Anxiolytic Drugs

1990 • 71 citations

Relationship between benzodiazepine receptor occupancy and potentiation of gamma-aminobutyric acid-stimulated chloride flux in vitro of four ligands of differing intrinsic efficacies.

1992 • 44 citations

Long-term treatment with abecarnil does not induce diazepam-like dependence in mice.

1993 • 43 citations

The first double-blind, placebo-controlled trial of a partial benzodiazepine agonist abecarnil (ZK 112-119) in generalized anxiety disorder.

1991 • 43 citations

Benzodiazepine receptor binding of nonbenzodiazepines in vivo: Alpidem, zolpidem and zopiclone

1992 • 43 citations

Pharmacokinetics, anticonvulsant efficacy and adverse effects of the beta-carboline abecarnil, a novel ligand for benzodiazepine receptors, after acute and chronic administration in dogs.

1990 • 41 citations

Demonstration of the partial agonist profiles of Ro 16-6028 and Ro 17-1812 in mice in vivo

1988 • 34 citations

Behavioral pharmacology of abecarnil in baboons

1992 • 32 citations

Comparative Study in Mice of Ten 1,4‐Benzodiazepines and of Clobazam: Anticonvulsant, Anxiolytic, Sedative, and Myorelaxant Effects

1986 • 32 citations

Behavioral interactions of fluoxetine and other 5-hydroxytryptamine uptake inhibitors with ethanol in tests of anxiety, locomotion and exploration

1988 • 31 citations

Withdrawal, tolerance and sensitization after a single dose of lorazepam

1988 • 24 citations

Antagonism of ethanol withdrawal convulsions in withdrawal seizure prone mice by diazepam and abecarnil

1992 • 23 citations

What are the differences between abecarnil and conventional benzodiazepine anxiolytics?

1992 • 14 citations