Teratogen update: Fetal effects of indomethacin administration during pregnancy

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

Drugs in Pregnancy and Lactation

1990 • 1,112 citations

Effects of indomethacin in premature infants with patent ductus arteriosus: Results of a national collaborative study

1983 • 558 citations

Closure of the Ductus Arteriosus in Premature Infants by Inhibition of Prostaglandin Synthesis

1976 • 505 citations

Neonatal Complications after the Administration of Indomethacin for Preterm Labor

1993 • 438 citations

Indomethacin in the Treatment of Premature Labor

1988 • 358 citations

Resistance of germfree rats to indomethacin-induced intestinal lesions

1977 • 313 citations

Effects of indomethacin on cerebral haemodynamics in very preterm infants

1990 • 298 citations

Renal complications of nonsteroidal anti-inflammatory drugs

1993 • 270 citations

INHIBITION OF HUMAN PREMATURE LABOR BY INDOMETHACIN

1975 • 260 citations

A Randomized, Controlled Trial of Very Early Prophylactic Ligation of the Ductus Arteriosus in Babies Who Weighed 1000 g or Less at Birth

1989 • 248 citations

The Role of Prostaglandins in the Central Nervous System

1979 • 241 citations

The inhibition of premature labor with indomethacin

1980 • 211 citations

Possible association between maternal indomethacin therapy and primary pulmonary hypertension of the newborn

1976 • 209 citations

First-trimester drug use and congenital disorders

1981 • 195 citations

The effects of an inhibitor of prostaglandin synthesis (indomethacin) on ovulation, pregnancy, and pseudopregnancy in the rabbit

1972 • 192 citations

Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use

1993 • 189 citations

Morphologic analysis of the pulmonary vascular bed in infants exposed in utero to prostaglandin synthetase inhibitors

1978 • 182 citations

Ligating the Ductus Arteriosus before Birth Causes Persistent Pulmonary Hypertension in the Newborn Lamb

1989 • 165 citations

Gastrointestinal perforation following indomethacin therapy in very low birth weight infants

1981 • 154 citations

The association of rapid volume expansion and intraventricular hemorrhage in the preterm infant

1980 • 141 citations

Pharmacokinetics of Indomethacin in the Neonate

1981 • 140 citations

Randomized comparative trial of indomethacin and ritodrine for the long-term treatment of preterm labor

1991 • 132 citations

Hemodynamic, pulmonary vascular, and myocardial abnormalities secondary to pharmacologic constriction of the fetal ductus arteriosus. A possible mechanism for persistent pulmonary hypertension and transient tricuspid insufficiency in the newborn infant.

1979 • 122 citations

Neonatal outcome after indomethacin treatment for preterm labor

1986 • 121 citations

Neonatal intracranial hemorrhage and maternal use of aspirin.

1981 • 119 citations

Effect of prolonged indomethacin therapy on renal function and selected vasoactive hormones in very-low-birth-weight infants with symptomatic patent ductus arteriosus

1983 • 118 citations

Ligating the Ductus Arteriosus before birth Remodels the Pulmonary Vasculature of the Lamb

1989 • 118 citations

Tocolysis with indomethacin increases the incidence of necrotizing enterocolitis in the low-birth-weight neonate

1994 • 118 citations

Further study of the inhibition of premature labor by indomethacin Part II double-blind study

1984 • 116 citations

Localized intestinal perforations after enteral administration of indomethacin in premature infants

1985 • 114 citations

Placental transfer of indomethacin in the human pregnancy

1990 • 113 citations

Fetal and neonatal effects of indomethacin used as a tocolytic agent

1985 • 110 citations

Randomized low-dose indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight neonates

1988 • 106 citations

Studies on closure of the ductus arteriosus. XII. effect of indomethacin and sodium salicylate in rats and rabbits

1975 • 105 citations

Relationship of maternal treatment with indomethacin to persistence of fetal circulation syndrome

1978 • 105 citations

Persistent anuria, neonatal death, and renal microcystic lesions after prenatal exposure to indomethacin

1994 • 103 citations

Oligohydramnios, renal insufficiency, and ileal perforation in preterm infants after intrauterine exposure to indomethacin

1988 • 96 citations

Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor; A randomized study

1990 • 94 citations

Patent Ductus Arteriosus, Indomethacin, and Intestinal Distension: Effects on Intestinal Blood Flow and Oxygen Consumption

1991 • 91 citations

Role of Coagulopathy in Newborn Intracranial Hemorrhage

1984 • 89 citations

Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor

1994 • 88 citations

Indomethacin Disposition and Indomethacin‐Induced Platelet Dysfunction in Premature Infants

1978 • 88 citations

Influence of short-term indomethacin therapy on fetal urine output.

1988 • 87 citations

Role of coagulopathy in newborn intracranial hemorrhage.

1984 • 85 citations

The effects of indomethacin and a β-sympathomimetic agent on the fetal ductus arteriosus during treatment of premature labor: A randomized double-blind study

1991 • 81 citations

The association between decreased amniotic fluid volume and treatment with nonsteroidal anti-inflammatory agents for preterm labor

1989 • 77 citations

The arachidonic acid cascade is involved in the masculinizing action of testosterone on embryonic external genitalia in mice.

1986 • 73 citations

Effect of indomethacin on basal and carbon dioxide stimulated cerebral blood flow in man

1981 • 71 citations

Prostaglandins Regulate Surfactant Protein A (SP-A) Gene Expression in Human Fetal Lungin Vitro*

1990 • 70 citations

Indomethacin, patent ductus arteriosus, and cerebral blood flow

1986 • 69 citations

Oligohydramnios and transient neonatal anuria: a possible association with the maternal use of prostaglandin synthetase inhibitors.

1980 • 68 citations

Prostaglandin Synthetase Inhibitors in Pregnancy

1993 • 67 citations

Differential effects of ibuprofen and indomethacin in the regional circulation of the dog.

1981 • 64 citations

Activity profiles of prostaglandin 15- and 9-hydroxydehydrogenase and 13-reductase in the developing rat kidney.

1975 • 64 citations

Prolonged bleeding time in preterm infants receiving indomethacin for patent ductus arteriosus

1984 • 64 citations

Long-Term Indomethacin Therapy Decreases Fetal Urine Output and Results in Oligohydramnios

1991 • 63 citations

A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor.

1991 • 62 citations

Persistent responsiveness of the neonatal ductus arteriosus in immature lambs: a possible cause for reopening of patent ductus arteriosus after indomethacin-induced closure.

1985 • 61 citations

Effects of indomethacin on labor, fetal oxygenation, and fetal development in rhesus monkeys.

1978 • 58 citations

Oligohydramnion, meconium and perinatal death concurrent with indomethacin treatment in human pregnancy.

1980 • 58 citations

CEREBRAL LESIONS IN PRETERM INFANTS AFTER TOCOLYTIC INDOMETHACIN

1990 • 58 citations

Randomized trial of oral indomethacin and terbutaline sulfate for the long-term suppression of preterm labor

1993 • 54 citations

Indomethacin-induced oligohydramnios

1989 • 53 citations

The Effect of Gestational Age and Fetal Indomethacin Levels on the Incidence of Constriction of the Fetal Ductus Arteriosus

1993 • 48 citations

Eicosanoids and the lungs.

1984 • 47 citations

Prostaglandins and the developing kidney.

1987 • 47 citations

Indomethacin and the fetal renal nonfunction syndrome

1983 • 46 citations

Neonatal renal dysfunction and intrauterine exposure to prostaglandin synthesis inhibitors

1989 • 45 citations

Vaginal birth after cesarean section: The impact of patient resistance to a trial of labor

1991 • 44 citations

[Pharmacokinetics of indomethacin in pregnant and parturient women and in their newborn infants].

1973 • 42 citations

Safety and Efficacy of Long-Term Tocolysis with Indomethacin

1990 • 42 citations

THE EFFECT OF INDOMETHACIN ON SPONTANEOUS ACTIVITY IN THE ISOLATED HUMAN MYOMETRIUM AND ON THE RESPONSE TO OXYTOCIN AND PROSTAGLANDIN

1978 • 42 citations

Indomethacin—Placental transfer, cytotoxicity, and teratology in the rat

1981 • 40 citations

A study of indomethacin combined with ritodrine in threatened preterm labor

1978 • 38 citations

Increased Constriction of the Ductus Arteriosus with Combined Administration of Indomethacin and Betamethasone in Fetal Rats

1989 • 37 citations

Right ventricular concentric hypertrophy and left ventricular dilatation by ductal constriction in fetal rats.

1989 • 35 citations

Renal dysgenesis in a monozygotic twin: Association with in utero exposure to indomethacin

1991 • 35 citations

The Hemodynamic Effects of Antenatal Indomethacin and a β-Sympathomimetic Agent on the Fetus and the Newborn: A Randomized Study

1993 • 29 citations

Hemodynamic changes induced by blockers of prostaglandin synthesis in the fetal lamb in utero.

1978 • 29 citations

Absence of teratogenicity of indomethacin in ovarian hyperstimulation syndrome.

1984 • 28 citations

Doppler assessment of the renal blood flow velocity waveform during indomethacin therapy for preterm labor and polyhydramnios.

1990 • 28 citations

Inhibition of fetal lung maturation by indomethacin in pregnant rabbits

1978 • 28 citations

Renal failure in two preterm infants: toxic effect of prenatal maternal indomethacin treatment?

1993 • 25 citations

Effect of indomethacin on alcohol-induced morphological anomalies in mice

1987 • 25 citations

Effect of dual tocolysis on the incidence of severe intraventricular hemorrhage among extremely low-birth-weight infants

1996 • 23 citations

Indomethacin for preterm labor: fetal toxicity in a dizygotic twin gestation.

1991 • 20 citations

Indomethacin administration after temporary ischemia causes bowel necrosis in mice

1992 • 18 citations

Effect of indomethacin on mesenteric circulation in mongrel dogs

1982 • 18 citations

Acute Maternal Renal Insufficiency in Premature Labor Treated with Indomethacin

1993 • 15 citations

Ultrastructural Changes of the Glomeruli of the Rat Induced by Indomethacin

1973 • 15 citations

The developmental toxicity of indomethacin and sulindac

1995 • 14 citations

Administration of prostaglandin inhibitors to the mother; the potential risk to the fetus and neonate with duct-dependent circulation

1991 • 13 citations

The effect of indomethacin tocolysis on maternal coagulation status

1995 • 13 citations

Premature onset of labor, neonatal patent ductus arteriosus, and prostaglandin synthetase antagonists—A rat model of a human problem

1979 • 9 citations

The effects of the administration of fenoprofen or indomethacin to rat dams during late pregnancy, with special reference to the ductus arteriousus of the fetuses and neonates

1978 • 9 citations

Effects of indomethacin and prostaglandins E2, I2, and D2 on the fetal circulation.

1983 • 8 citations

Oligohydramnios induced by maternal indomethacin therapy.

1992 • 5 citations

Maternal renal impairment after indomethacin tocolysis.

1993 • 5 citations

Serum creatinine levels in preterm infants after intrauterine exposure to indomethacin

1988 • 2 citations

Deleted Work

1955 • 0 citations