Inhibitory Effect of NS‐398, a Selective Cyclooxygenase‐2 Inhibitor, on Azoxymethane‐induced Aberrant Crypt Foci in Colon Carcinogenesis of F344 Rats

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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

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TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

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1991 • 1,695 citations

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1992 • 1,493 citations

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The nucleotide sequence of the rat cytoplasmic β–actin gene

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1987 • 1,036 citations

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NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1994 • 826 citations

Sulindac causes regression of rectal polyps in familial adenomatous polyposis

1991 • 736 citations

Prostaglandin endoperoxide synthase: structure and catalysis

1991 • 607 citations

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Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process

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A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer

1991 • 519 citations

Cloning Two Isoforms of Rat Cyclooxygenase: Differential Regulation of Their Expression

1993 • 457 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

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1996 • 421 citations

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

1995 • 400 citations

Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats

1993 • 353 citations

Nonsteroidal Antiinflammatory Drugs Inhibit the Proliferation of Colon Adenocarcinoma Cells: Effects on Cell Cycle and Apoptosis

1996 • 343 citations

Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development.

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GASTROSCOPIC OBSERVATION OF THE EFFECT OF ASPIRIN AND CERTAIN OTHER SUBSTANCES ON THE STOMACH

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1996 • 173 citations

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Cyclooxygenase Gene Expression in Inflammation and Angiogenesis^a

1993 • 169 citations

Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation

1993 • 151 citations

Concentrations of prostaglandin endoperoxide synthase and prostaglandin I2 synthase in the endothelium and smooth muscle of bovine aorta.

1983 • 148 citations

Apoptosis Induced by NS‐398, a Selective Cyclooxygenase‐2 Inhibitor, in Human Colorectal Cancer Cell Lines

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1983 • 97 citations

Suppression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase 2

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Renal Insufficiency Associated With Nonsteroidal Anti-inflammatory Agents

1984 • 52 citations

Chemoprevention of azoxymethane-induced colon carcinogenesis by dietary feeding of S-methyl methane thiosulfonate in male F344 rats.

1995 • 42 citations

Inhibitory effects of magnesium hydroxide on c-myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon

1993 • 34 citations

Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats

1991 • 33 citations

Investigation of colonic prostaglandins in carcinogenesis in the rat colon

1991 • 32 citations

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1996 • 31 citations

Perspectives on Cancer in Japan and the United States'

1993 • 29 citations

Cell kinetic analysis of the mucosal epithelium and assay of ornithine decarboxylase activity during the process of 1-hydroxyanthraquinone-induced large bowel carcinogenesis in rats

1992 • 25 citations

The mRNA overexpression of inflammatory enzymes, phospholipase A2 and cyclooxygenase, in the large bowel mucosa and neoplasms of F344 rats treated with naturally occurring carcinogen, 1-hydroxyanthraquinone

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Inflammation: From molecular biology to clinic

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