The Emerging Concept of Relaxn as a Centrally Actng Peptide Hormone with Hemodynamic Actions

Physiology of Reproduction

2000 • 1,121 citations

Oxford reviews of reproductive biology

1981 • 752 citations

Circulating and tissue angiotensin systems.

1987 • 616 citations

The efferent projections of the subfornical organ of the rat: A circumventricular organ within a neural network subserving water balance

1981 • 548 citations

Brain and Pituitary Angiotensin

1992 • 463 citations

Experimental relaxation of the pubic ligament of the guinea pig.

1926 • 395 citations

Anisosmotic cell volume regulation: a comparative view

1989 • 394 citations

An HRP study of the connections of the subfornical organ of the rat

1982 • 345 citations

The Circumventricular Organs and the Central Actions of Angiotensin

1981 • 324 citations

Purification and characterization of porcine relaxin

1974 • 312 citations

Pathways to the Secretion of Adrenocorticotropin: A View from the Portal*

1991 • 255 citations

Recent Advances in Blood-Brain Barrier Transport

1988 • 230 citations

Morphometric analysis of CNS microvascular endothelium

1985 • 192 citations

Radioimitnunoassay of Relaxin throughout Pregnancy and during Parturition in the Rat*

1980 • 178 citations

Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal

1989 • 173 citations

Endothelial Cell‐Astrocyte Interactions

1988 • 140 citations

Autoradiographic localization of relaxin binding sites in rat brain.

1991 • 138 citations

Osmoregulation of thirst and vasopressin release in pregnancy

1989 • 122 citations

Cardiac effects of relaxin in rats

1992 • 120 citations

Vasopressin release to central and peripheral angiotensin II in rats with lesions of the subfornical organ

1984 • 108 citations

Chronic decrease of blood pressure by rat relaxin in spontaneously hypertensive rats

1985 • 108 citations

Dithranol: A Review of the Mechanism of Action in the Treatment of Psoriasis vulgaris

1990 • 100 citations

Expression of relaxin mRNA and relaxin receptors in postnatal and adult rat brains and hearts. Localization and developmental patterns

1993 • 99 citations

Relaxin alters the plasma osmolality-arginine vasopressin relationship in the rat

1993 • 96 citations

Purification and Characterization of Rat Relaxin*

1979 • 82 citations

Relaxin affects the central control of oxytocin release

1984 • 79 citations

The Uteroplacental Renin-Angiotensin System in Normal and Hypertensive Pregnancy

2015 • 76 citations

Role of volume in the regulation of vasopressin secretion during pregnancy in the rat.

1984 • 75 citations

Relaxin affects the release of oxytocin and vasopressin from the neurohypophysis

1987 • 74 citations

Relaxin increases the firing rate of supraoptic neurones and increases oxytocin secretion in the rat

1992 • 73 citations

Handbook of Hypertension

1989 • 68 citations

Neurophysin biosynthesis in normal rats and in rats with hereditary diabetes insipidus.

1977 • 63 citations

Lesion of the subfornical organ affects the haemotensive response to centrally administered relaxin in anaesthetized rats

1989 • 57 citations

Relaxin increases heart rate by modulating calcium current in cardiac pacemaker cells.

1994 • 56 citations

Target Tissues for Relaxin in the Rat: Tissue Distribution of Injected¹²⁵I-Labeled Relaxin and Tissue Changes in Adenosine 3′, 5′-Monophosphate Levels afterin VitroRelaxin Incubation*

1980 • 56 citations

The Antihypertensive Effect of Pregnancy in Spontaneously Hypertensive Rats

1976 • 54 citations

Relaxin increases rat heart rate by a direct action on the cardiac atrium

1992 • 53 citations

Monoclonal antibodies specific for rat relaxin. VI. Passive immunization with monoclonal antibodies throughout the second half of pregnancy disrupts histological changes associated with cervical softening at parturition in rats.

1992 • 52 citations

Monoclonal antibodies specific for rat relaxin. VII. Passive immunization with monoclonal antibodies throughout the second half of pregnancy prevents development of normal mammary nipple morphology and function in rats.

1992 • 51 citations

The Effect of Relaxin Infusion on Prolactin and Growth Hormone Secretion in Monkeys*

1989 • 45 citations

Characterization of the binding of 125I-relaxin to rat uterus.

1980 • 44 citations

Ovarian Control of Pituitary Hormone Secretion in Early Human Pregnancy*

1991 • 44 citations

Effects of Relaxin on Blood Pressure and the Release of Vasopressin and Oxytocin in Anesthetized Rats during Pregnancy and Lactation1

1994 • 43 citations

Relaxin Stimulates Prolactin Secretion from Anterior Pituitary Cells*

1989 • 43 citations

Effects of relaxin on the microvasculature of mouse mammary gland.

1988 • 41 citations

Mechanism of the Haemotensive Action of Porcine Relaxin in Anaesthetized Rats

1990 • 40 citations

Brain angiotensin-II partially mediates the effects of relaxin on vasopressin and oxytocin release in anesthetized rats.

1994 • 39 citations

Morphological Changes Induced in Mouse Mammary Gland by Porcine and Human Relaxin

1984 • 39 citations

Relaxin acts centrally to inhibit oxytocin release during parturition: an effect that is reversed by naloxone

1986 • 38 citations

Target tissues for relaxin identified in vitro with 125I-labelled porcine relaxin

1978 • 37 citations

The subfornical organ and relaxin-induced inhibition of reflex milk ejection in lactating rats

1987 • 37 citations

The action of aqueous corpus luteum extract upon uterine activity.

1950 • 37 citations

Osmoregulation and vasopressin secretion during pregnancy in Brattleboro rats

1985 • 27 citations

Effects of porcine relaxin on oxytocin release from the neurohypophysis in the anaesthetized lactating rat

1986 • 26 citations

Central Angiotensin Partially Mediates the Pressor Action of Relaxin in Anesthetized Rats*

1991 • 25 citations

Ultrastructural Localization of Relaxin Immunoreactivity in Corpora Lutea of Pregnant Rats*

1984 • 25 citations

Vasomotor projections from the anteroventral third ventricle (AV3V) region

1984 • 25 citations

Evidence for a dual source of relaxin in the pregnant rat: immunolocalization in the corpora lutea and endometrium.

1992 • 24 citations

Lack of evidence of a vasodepressor role for relaxin in spontaneously hypertensive and normotensive pregnant rats

1989 • 23 citations

The effects of relaxin-containing ovarian extracts on various types of smooth muscle.

1957 • 23 citations

Monoclonal antibodies specific for rat relaxin. VII. Passive immunization with monoclonal antibodies throughout the second half of pregnancy prevents development of normal mammary nipple morphology and function in rats

1992 • 19 citations

Effects of porcine relaxin on the length of gestation and duration of parturition in the rat

1986 • 18 citations

Role of the subfornical organ in the relaxin-induced prolongation of gestation in the rat.

1994 • 18 citations

THE MECHANISM OF SYMPHYSEAL RELAXATION. THE DISTRIBUTION OF REDUCING GROUPS, HEXOSEAMINE, AND PROTEINS IN SYMPHYSES OF NORMAL AND RELAXED GUINEA PIGS¹

1951 • 17 citations

Effects of ovariectomy and of hormones on collagenous framework of the uterus

1964 • 16 citations

Isolation of the Relaxative Hormone on the Corpus Luteum.

1930 • 14 citations

Monoclonal antibodies specific for rat relaxin. VI. Passive immunization with monoclonal antibodies throughout the second half of pregnancy disrupts histological changes associated with cervical softening at parturition in rats

1992 • 14 citations

Brain angiotensin-II partially mediates the effects of relaxin on vasopressin and oxytocin release in anesthetized rats

1994 • 13 citations

Effects of chronic infusion of porcine relaxin on oxytocin release in lactating rats

1987 • 13 citations

Brain Angiotensin

1983 • 12 citations

Porcine Relaxin Affects the Release of Luteinizing Hormone in Rats

1991 • 12 citations

Lack of cardiovascular and vasopressin responses to human relaxin in conscious, late-pregnant rats

1991 • 11 citations

TISSUE DISTRIBUTION OF INJECTED ¹²⁵I‐LABELED PORCINE RELAXIN: ORGAN UPTAKE, WHOLE‐BODY AUTORADIOGRAPHY, AND RENAL CONCENTRATION OF RADIOMETABOLITES

1982 • 11 citations

Effects of exogenous relaxin on oxytocin and vasopressin release and the intramammary pressure response to central hyperosmotic challenge

1994 • 11 citations

Central inhibitory effects of relaxin on the milk ejection reflex of the rat depends upon the site of injection into the cerebroventricular system

1987 • 10 citations

Role for central angiotensin II in control of blood pressure during pregnancy

1989 • 10 citations

Evidence for a dual source of relaxin in the pregnant rat: immunolocalization in the corpora lutea and endometrium

1992 • 9 citations

Role of the subfornical organ in the relaxin-induced prolongation of gestation in the rat

1994 • 7 citations

In vivo Uptake of 125I-Relaxin in the Guinea Pig

1981 • 6 citations