Activation of Caspases in p53‐induced Transactivation‐independent Apoptosis

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1996 • 1,001 citations

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1996 • 980 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

A Selective Procedure for DNA Extraction from Apoptotic Cells Applicable for Gel Electrophoresis and Flow Cytometry

1994 • 670 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1995 • 546 citations

Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases

1996 • 519 citations

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1996 • 459 citations

The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.

1997 • 456 citations

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis

1997 • 370 citations

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.

1996 • 318 citations

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

1996 • 283 citations

Essential role for p53-mediated transcription in E1A-induced apoptosis.

1995 • 219 citations

Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells.

1997 • 183 citations

Activation of Caspase-2 in Apoptosis

1997 • 181 citations

Involvement of p85 in p53-dependent apoptotic response to oxidative stress

1998 • 154 citations

p53-dependent DNA damage-induced apoptosis requires Fas/APO-1-independent activation of CPP32beta.

1997 • 130 citations

Interleukin 1 beta converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis.

1997 • 58 citations

A human temperature-sensitive p53 mutant p53Val-138: modulation of the cell cycle, viability and expression of p53-responsive genes.

1995 • 41 citations

p53-induced apoptosis in the human T-ALL cell line CCRF-CEM

1997 • 40 citations

Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis

1997 • 33 citations

Epitope analysis of the murine p53 tumour suppressor protein.

1996 • 32 citations

Structural and kinetic analysis of p53-DNA complexes and comparison of human and murine p53.

1995 • 14 citations

Analysis of downstream effectors of p53 on cell growth arrest and apoptosis induced by a temperature-sensitive Val138 mutant.

1998 • 5 citations