Use of ?-asparaginase in childhood ALL

Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

1993 • 1,997 citations

REGRESSION OF TRANSPLANTED LYMPHOMAS INDUCED IN VIVO BY MEANS OF NORMAL GUINEA PIG SERUM

1953 • 399 citations

Tumor inhibitory effect of l-asparaginase from Escherichia coli

1964 • 398 citations

EVIDENCE THAT THE <scp>L</scp>-ASPARAGINASE OF GUINEA PIG SERUM IS RESPONSIBLE FOR ITS ANTILYMPHOMA EFFECTS

1963 • 334 citations

Comparative pharmacokinetic studies of three asparaginase preparations.

1993 • 328 citations

L-Asparaginase Therapy for Leukemia and Other Malignant Neoplasms

1967 • 296 citations

Toxicity of E. coli L-asparaginase in man

1970 • 290 citations

Inhibition of leukemias in man by L-asparaginase.

1967 • 276 citations

L‐Asparaginase: A Review

1973 • 271 citations

L-Asparaginase

1969 • 265 citations

Two L-Asparaginases from Escherichia coli B. Their Separation, Purification, and Antitumor Activity^*

1967 • 228 citations

Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations

1996 • 210 citations

STUDIES ON THE MECHANISM OF TUMOR INHIBITION BY L-ASPARAGINASE

1968 • 204 citations

Increased endogenous thrombin generation in children with acute lymphoblastic leukemia: risk of thrombotic complications in L'Asparaginase-induced antithrombin III deficiency

1994 • 202 citations

Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia.

1983 • 192 citations

Toxicity of L-asparaginase in children with advanced leukemia

1972 • 187 citations

L-Asparaginase: Clinical, Biochemical, Pharmacological, and Immunological Studies

1971 • 181 citations

L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia.

1977 • 180 citations

E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children

1970 • 172 citations

Polymer Conjugates

1994 • 167 citations

Asparaginase-Associated Lipid Abnormalities in Children With Acute Lymphoblastic Leukemia

1997 • 164 citations

L-Asparaginase and L-Asparagine Metabolism

1970 • 160 citations

L-asparaginase pharmacokinetics and asparagine levels in cerebrospinal fluid of rhesus monkeys and humans.

1981 • 159 citations

Biochemical and pharmacological studies with asparaginase in man.

1970 • 156 citations

Hypersensitive reactions and antibody formation during L-asparaginase treatment of children and adults with acute leukemia

1976 • 144 citations

SUPPRESSION OF MURINE LEUKEMIAS BY <scp>L</scp>-ASPARAGINASE

1967 • 138 citations

Risk factors for hyperglycemia in children with leukemia receiving l-asparaginase and prednisone

1981 • 133 citations

Cell killing studies on the mode of action of methotrexate on L-cells in vitro.

1969 • 132 citations

Toxic and antineoplastic effects of l-asparaginase: Study of mice with lymphoma and normal monkeys and report on a child with leukemia

1966 • 129 citations

Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia: a report from Childrens Cancer Study Group.

1979 • 128 citations

Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors

1970 • 126 citations

Two L-asparaginases from E. coli and their action against tumors.

1966 • 123 citations

Dual Requirement of Walker Carcinosarcoma 256 in vitro for Asparagine and Glutamine

1956 • 121 citations

The requirement for L-asparagine of mouse leukemia cells L5178Y in culture.

1961 • 119 citations

L-Asparaginase

1970 • 117 citations

Dose reduction of asparaginase under pharmacokinetic and pharmacodynamic control during induction therapy in children with acute lymphoblastic leukaemia

1997 • 115 citations

L-asparaginase kills lymphoma cells by apoptosis

1993 • 110 citations

Anaphylactoid reactions to escherichia coli and erwinia asparaginase in children with leukemia and lymphoma

1982 • 109 citations

The antitumor activity of Escherichia coli L-asparaginase.

1966 • 106 citations

A probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard, or X-irradiation.

1970 • 99 citations

Purification and characterization of L-asparaginase with anti-lymphoma activity from Vibrio succinogenes.

1976 • 99 citations

Reduction in immunogenicity and clearance rate of Escherichia coli L-asparaginase by modification with monomethoxypolyethylene glycol.

1981 • 93 citations

Evaluation of intramuscular versus intravenous administration of L-asparaginase in childhood leukemia.

1979 • 90 citations

Purification and properties of asparaginase from Escherichia coli B

1969 • 90 citations

A NEW L-ASPARAGINASE WITH ANTITUMOUR ACTIVITY

1968 • 90 citations

Antilymphoma Activity of &lt;sc&gt;L&lt;/sc&gt;-Asparaginase &lt;italic&gt;In Vivo:&lt;/italic&gt; Clearance Rates of Enzyme Preparations From Guinea Pig Serum and Yeast in Relation to Their Effect on Tumor Growth

1965 • 90 citations

La Désamidation Enzymatique De L'asparagine Chez Les Différentes Espéces Animales Et La Signification Physio Logique De Sa Presence Dans L'organisme

1922 • 89 citations

L-Asparaginase in Treatment of Acute Leukaemia and Lymphosarcoma

1970 • 88 citations

<scp>L</scp> -Asparaginase: Inhibition of Early Mitosis in Regenerating Rat Liver

1967 • 88 citations

Amino acid levels following L-asparagine amidohydrolase (EC.3.5.1.1) therapy.

1969 • 87 citations

Asparaginase and Glutaminase Activities of Bacteria

1971 • 86 citations

Non‐randomised study comparing toxicity of escherichia coli and erwinia asparaginase in children with leukaemia

1990 • 84 citations

Factors which may influence the effectiveness of L-asparaginases as tumor inhibitors

1968 • 83 citations

Optimal use of L‐asparaginase (NSC‐109229) in acute lymphocytic leukemia

1977 • 83 citations

Characterization of polyethylene glycol-modified L-asparaginase from Escherichia coli and its application to therapy of leukemia.

1986 • 80 citations

Characterization of Apoptotic Phenomena Induced by Treatment with L-Asparaginase in NIH3T3 Cells

1995 • 77 citations

Latent onset of clinical pancreatitis in children receiving l-asparaginase therapy

1974 • 77 citations

Antibody response to Escherichia coli L-asparaginase. Prognostic significance and clinical utility of antibody measurement.

1986 • 74 citations

L-asparaginase in the treatment of neoplastic diseases in children.

1971 • 72 citations

Transient, severe hyperlipidemia in patients with acute lymphoblastic leukemia treated with prednisone and asparaginase

1994 • 71 citations

Allergic reactions toErwinia asparaginase in children with acute lymphoblastic leukemia who had previous allergic reactions toescherichia coli asparaginase

1992 • 66 citations

[79] Asparaginase

1985 • 64 citations

L-Asparaginase EC-2 from Escherichia coli. Some substrate specificity characteristics

1969 • 63 citations

Hydrolysis of amides by extracts from mycobacteria

1957 • 63 citations

Acute leukemias?prognostic factors and treatment strategies

1989 • 61 citations

L-Asparaginase: discovery and development as a tumor-inhibitory agent.

1981 • 61 citations

Comparison of anaphylactic reactions to asparaginase derived fromEscherichia coli and fromErwinia culturs

1976 • 60 citations

L-asparaginase therapy in children with advanced leukemiaThe Southwest cancer chemotherapy study group

1971 • 59 citations

L-asparaginase activity in plasma and other biological fluids

1970 • 58 citations

Antitumor Enzyme: Polyethylene Glycol–modified Asparaginase

1990 • 57 citations

Methotrexate and asparaginase combination chemotherapy in refractory acute lymphoblastic leukemia of childhood

1979 • 57 citations

Anaphylaxis to L-Asparaginase during Treatment for Acute Lymphoblastic Leukemia in Children—Evidence of a Complement-Mediated Mechanism

1985 • 56 citations

Comparison of daily versus weeklyl-asparaginase for the treatment of childhood acute leukemia

1970 • 55 citations

Effect of L-asparaginase on carbohydrate metabolism

1970 • 55 citations

Altered von Willebrand factor molecule in children with thrombosis following asparaginase-prednisone-vincristine therapy for leukemia.

1985 • 53 citations

Erwinia carotovora asparaginase in patients with prior anaphylaxis to asparaginase from E. coli

1972 • 52 citations

A Metabolic Difference Between Two Lines of Lymphoma 6C3HED Cells in Relation to Asparagine.

1965 • 51 citations

Adverse reactions of L-asparaginase.

1982 • 48 citations

The effect of L-asparaginase on lipid metabolism during induction chemotherapy of childhood lymphoblastic leukaemia

1988 • 47 citations

Antitumor activity and other biologic properties of L-asparaginase (NSC-109229)-a review.

1968 • 46 citations

Experimental and Clinical Effects of L-Asparaginase

1970 • 46 citations

The clinical toxicities of L-asparaginase in treatment of leukemia and lymphoma.

1970 • 42 citations

L-asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia

1967 • 42 citations

Electroencephalogram Changes Secondary to Asparaginase

1970 • 42 citations

Studies on unbalanced growth in synchronized HeLa cells.

1968 • 42 citations

L-Asparagine depletion in plasma and cerebro-spinal fluid of children with acute lymphoblastic leukemia during subsequent exposures to Erwinia L-asparaginase

1996 • 42 citations

Diabetes in patients treated with asparaginase

1971 • 41 citations

Favorable remission induction rate with twice weekly doses of L-asparaginase.

1973 • 41 citations

More is Better! Update of Dana-Farber Cancer Institute/Children’s Hospital Childhood Acute Lymphoblastic Leukemia Trials

1990 • 41 citations

The Intracellular Enzymes of Lower Fungi, Especially those of Penicillium Camemberti

1909 • 41 citations

Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lymphoblastic leukemia

1994 • 40 citations

Psychiatric symptoms associated with L-asparaginase administration

1974 • 38 citations

A METHOD OF SELECTING FOR AUXOTROPHIC MUTANTS OF H<scp>E</scp>L<scp>A</scp> CELLS

1960 • 38 citations

The Enzymic Deamidation of Asparagine in the Higher Plants

1927 • 36 citations

Changes in hemostatic and fibrinolytic proteins in patients receiving L‐asparaginase therapy

1989 • 36 citations

THE CLINICAL TOXICITIES OF L-ASPARAGINASE

1970 • 36 citations

Levels of L-asparagine in CSF after intramuscular administration of asparaginase from Erwinia in children with acute lymphoblastic leukemia.

1995 • 36 citations

Enhanced thrombin generation, P-von willebrand factor, P-fibrin D-dimer and P-plasminogen activator inhibitor 1: Predictive for venous thrombosis in asparaginase-treated children

1994 • 35 citations

Influence of α Keto Acids on the Desamidation of Amino Acid Amides

1946 • 35 citations

Surgical pancreatic complications induced by l-asparaginase

1997 • 34 citations

Clinical pharmacologic studies of L‐asparaginase

1970 • 34 citations

Hyperglycemia associated with the therapeutic use of l-asparaginase: Possible role of insulin receptors

1978 • 33 citations

Improved survival of infants less than 1 year of age with acute lymphoblastic leukemia treated with intensive multiagent chemotherapy.

1987 • 33 citations

Pharmacokinetics and drug monitoring of L-asparaginase treatment.

1997 • 33 citations

Changes in coagulation and fibrinolysis in childhood ALL: a two‐step dose reduction of one E. coli asparaginase preparation

1996 • 33 citations

Treatment of adult leukemia with L-asparaginase (NSC-109229).

1971 • 32 citations

SCHEDULE-DEPENDENT SYNERGISM AND ANTAGONISM BETWEEN METHOTREXATE AND ASPARAGINASE

1975 • 32 citations

Stereospecific asparaginases in smooth Brucella abortus, strain 19

1954 • 32 citations

[Drug interactions. 2].

1970 • 31 citations

Gerinnungsveränderungen bei Behandlung mit den Protokollen ALL-BFM-90 und NHL-BFM-90

1992 • 30 citations

Transient diabetes mellitus secondary to L-asparaginase therapy in acute leukemia

1972 • 29 citations

L-asparaginase induced antithrombin III deficiency: Evidence against the production of a hypercoagulable state

1983 • 29 citations

Resistance to activated protein C (APCR) in children with acute lymphoblastic leukaemia???the need for a prospective multicentre study

1995 • 28 citations

Effects of L-Asparaginase in Acute Myelocytic Leukemia

1969 • 27 citations

Delayed pancreatic pseudocyst formation long-term complication of L-asparaginase treatment

1982 • 25 citations

Methotrexate/L-asparaginase combination chemotherapy for patients with acute leukemia in relapse: A study of 36 children

1980 • 24 citations

THE ASPARAGINE DEAMIDASE OF BACILLUS COAGULANS AND BACILLUS STEAROTHERMOPHILUS

1957 • 24 citations

Low-Dosage Asparaginase Treatment of Childhood Acute Lymphocytic Leukemia

1971 • 23 citations

L-asparaginase-induced modulation of methotrexate polyglutamylation in murine leukemia L5178Y.

1987 • 23 citations

L-Asparaginase as a single agent in acute lymphocytic leukemia: survey of studies form Childrens Cancer Study Group.

1981 • 23 citations

Asparaginase and methotrexate combination chemotherapy in relapsed acute lymphoblastic leukemia in adults.

1981 • 23 citations

Clinical Pharmacology of Intramuscularly Administeredl-Asparaginase

1981 • 23 citations

L-ASPARAGINASE AND PANCREATITIS

1970 • 21 citations

l-Asparaginase: Inhibition of endogenous RNA polymerase activity regenerating liver

1969 • 21 citations

Asparaginase Activities In Vitro Are Highly Sensitive to Different Buffer Conditions

1997 • 21 citations

Desamidation of Glutamine and Asparagine in Normal and Neoplastic Hepatic Tissues

1947 • 19 citations

The effect of E. Coli L-asparaginase on oral glucose tolerance and insulin release in man

1978 • 16 citations

The action of Pseudomonas fluorescens extracts on asparagine and asparagine derivatives

1960 • 15 citations

Myelosuppressive Effect of Colaspase (L-Asparaginase) in Initial Treatment of Acute Lymphoblastic Leukaemia

1974 • 14 citations

Use of L‐asparaginase and cytosine arabinoside for refractory acute lymphocytic leukemia with particular reference to T‐cell leukemia

1978 • 13 citations

Diabetes mellitus secondary to l-asparaginase therapy

1972 • 13 citations

Elimination of l-Asparaginase in Children Treated for Acute Lymphoblastic Leukemia

1989 • 13 citations

Treatment of Acute Leukemia with L-Asparaginase — Preliminary Results on 84 Cases

1970 • 12 citations

The place of the L-asparaginase in the treatment of acute leukemias.

1970 • 11 citations

The Place of the L-Asparaginase in the Treatment of Acute Leukemias

1970 • 10 citations

Acute haemorrhagic pancreatitis following L-asparaginase therapy in acute lymphoblastic leukaemia --a case report.

1974 • 10 citations

TOXICITY OF ASPARAGINASES

1975 • 10 citations

The Partitioning of L-Asparaginase between Blood and Lymph

1970 • 9 citations

Nonketotic hyperglycemia due to prednisone (NSC-10023) following ketotic hyperglycemia due to L-asparaginase (NSC-109229) plus prednisone.

1972 • 9 citations

Pegaspargase (Polyethylene Glycol-L-Asparaginase)

1996 • 9 citations

Effects of L-asparaginase in acute myelocytic leukemia

1969 • 9 citations

L-Asparaginase from Escherichia coli

1971 • 9 citations

Hyperglucagonemia in L-asparaginase induced diabetes mellitus.

1986 • 8 citations

L-asparaginase-related pancreatic pseudocyst: report of a case.

1994 • 8 citations

Hyperglucagonemia in L-Asparaginase Induced Diabetes Mellitus

1986 • 6 citations

On the Distribution of Aspnrnginase

1944 • 6 citations

Asparagine Synthetase in Pediatric Acute Leukemias: AML-M5 Subtype Shows Lowest Activity

1998 • 5 citations

Inactivation of Complement by L-Asparaginase Preparations not Correlated with Enzyme Content

1972 • 5 citations

Pegaspargase (Polyethylene Glycol-L-Asparaginase)

1996 • 4 citations

The Distribution and Clearance of L-Asparaginase

1970 • 4 citations

Combination versus single drug therapy.

1960 • 3 citations

[Leukocytic changes under treatment with L-asparaginase].

1971 • 3 citations

[A case of ALL complicated with acute pancreatitis and pancreatic pseudocyst caused by L-asparaginase ].

1993 • 2 citations

Endothelial vWf and t-PA release after incubation with different concentrations of asparaginase and dexamethasone

1996 • 2 citations

Diabetische Stoffwechselentgleisung bei Leuk�miebehandlung

1970 • 1 citations

Deleted Work

1955 • 0 citations