Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts

Intake of Carotenoids and Retino in Relation to Risk of Prostate Cancer

1995 • 1,356 citations

Toward a Science of Metabolic Engineering

1991 • 1,137 citations

Biological functions and activities of animal carotenoids

1991 • 931 citations

Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate‐independent pathway

1997 • 700 citations

Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli

1990 • 573 citations

Astaxanthin from Microbial Sources

1991 • 509 citations

Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level

1995 • 437 citations

The nucleotide sequence of pACYC184

1988 • 407 citations

Nucleotide sequence, organization, and nature of the protein products of the carotenoid biosynthesis gene cluster of Rhodobacter capsulatus

1989 • 356 citations

Chemistry and Biochemistry

1982 • 288 citations

Microbial sources of carotenoid pigments used in foods and feeds

1991 • 221 citations

Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli

1997 • 207 citations

In Vitro Characterization of Astaxanthin Biosynthetic Enzymes

1997 • 179 citations

Distribution and analysis of carotenoids.

1988 • 172 citations

Production of the Carotenoids Lycopene, β-Carotene, and Astaxanthin in the Food Yeast Candida utilis

1998 • 164 citations

Metabolic Engineering for Production ofβ-Carotene and Lycopene inSaccharomyces cerevisiae

1994 • 156 citations

Construction of Metabolic Operons Catalyzing the De Novo Biosynthesis of Indigo in Escherichia coli

1993 • 150 citations

The biology of HMG-CoA reductase: the pros of contra-regulation

1996 • 146 citations

Metabolic Engineering To Produce Tyrosine or Phenylalanine in a Tryptophan-Producing Corynebacterium glutamicum Strain

1992 • 120 citations

Production of Astaxanthin and 4-Ketozeaxanthin by the Marine Bacterium,Agrobacterium aurantiacum

1994 • 115 citations

Expression in Escherichia coli, purification, and reactivation of the recombinant Erwinia uredovora phytoene desaturase.

1992 • 111 citations

Isopentenyl diphosphate:dimethylallyl diphosphate isomerase

1989 • 99 citations

Production of Food and Fodder Yeasts

1992 • 97 citations

Xanthophylls as precursors of retinoids

1991 • 96 citations

Canthaxanthin Biosynthesis by the Conversion of Methylene to Keto Groups in a Hydrocarbon β-Carotene by a Single Gene

1995 • 92 citations

Production of zeaxanthin in Escherichia coli transformed with different carotenogenic plasmids

1997 • 91 citations

Functional expression of zeaxanthin glucosyltransferase from Erwinia herbicola and a proposed uridine diphosphate binding site.

1992 • 90 citations

Cloning and regulation of Erwinia herbicola pigment genes

1986 • 88 citations

Studies of immunomodulating actions of carotenoids. I. Effects ofβ‐carotene and astaxanthin on murine lymphocyte functions and cell surface marker expression inin vitroculture system

1991 • 85 citations

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Saccharomyces cerevisiae.

1994 • 77 citations

Expression, purification and properties of lycopene cyclase from Erwinia uredovora

1996 • 66 citations

A transformation system for the yeast Candida utilis: use of a modified endogenous ribosomal protein gene as a drug-resistant marker and ribosomal DNA as an integration target for vector DNA

1995 • 65 citations

Production of beta-carotene in Zymomonas mobilis and Agrobacterium tumefaciens by introduction of the biosynthesis genes from Erwinia uredovora

1991 • 64 citations

New functional assignment of the carotenogenic genes crtB and crtE with constructs of these genes from Erwinia species

1992 • 63 citations

New functional assignment of the carotenogenic genescrtBandcrtEwith constructs of these genes fromErwiniaspecies

1992 • 61 citations

In vitro expression and activity of lycopene cyclase and β‐carotene hydroxylase from Erwinia herbicola

1993 • 60 citations

The Carotenoid 7, 8‐Dihydro‐ψ end Group can be Cyclized by the Lycopene Cyclases from the Bacterium Erwinia Uredovora and the Higher Plant Capsicum Annuum

1996 • 58 citations

Production of lycopene by the food yeast,Candida utilis that does not naturally synthesize carotenoid

1998 • 54 citations

CAROTENOIDS OF Erwinia herbicola AND AN Escherichia coli HB101 STRAIN CARRYING THE Erwinia herbicola CAROTENOID GENE CLUSTER

1991 • 49 citations

Isolation and characterization of isoprene mutants of Escherichia coli

1989 • 46 citations

Metabolic engineering

1994 • 46 citations

Isolation and characterization of the carotenoid biosynthesis genes of Flavobacterium sp. strain R1534

1997 • 46 citations

Analysis of the gene cluster encoding carotenoid biosynthesis in Erwinia herbicola Eho13

1994 • 41 citations

Carotenoids in Medicine

1989 • 35 citations

Development of a new commercial-scale airlift fermentor for rapid growth of yeast

1993 • 35 citations

An alternative pathway for the biosynthesis of isoprenoid compounds in bacteria

1981 • 31 citations

Purification and Enzymatic Characterization of the Geranylgeranyl Pyrophosphate Synthase from Erwinia uredovora After Expression in Escherichia coli

1993 • 26 citations

Plasmids of the Epiphytic Bacterium Erwinia uredovora

1984 • 23 citations

Animal Carotenoids

1989 • 20 citations

Analysis of Carotenoid Glycosides Produced in Gram-negative Bactera by Introduction of the Erwinia uredovora Carotenoid Biosynthesis Genes.

1991 • 15 citations